7aa0 - Revision history

OCA at 12:05, 1 February 2024

OCA — Thu, 01 Feb 2024 12:05:55 GMT

←Older revision		Revision as of 12:05, 1 February 2024
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	==Structural comparison of cellular retinoic acid binding protein I and II in the presence and absence of natural and synthetic ligands==		==Structural comparison of cellular retinoic acid binding protein I and II in the presence and absence of natural and synthetic ligands==
-	<StructureSection load='7aa0' size='340' side='right'caption='[[7aa0]]' scene=''>	+	<StructureSection load='7aa0' size='340' side='right'caption='[[7aa0]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AA0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7aa0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AA0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aa0 OCA], [https://pdbe.org/7aa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aa0 RCSB], [https://www.ebi.ac.uk/pdbsum/7aa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aa0 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.82Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R6B:(~{E})-3-[4-(4,4-dimethyl-1-propan-2-yl-2,3-dihydroquinolin-6-yl)phenyl]prop-2-enoic+acid'>R6B</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aa0 OCA], [https://pdbe.org/7aa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aa0 RCSB], [https://www.ebi.ac.uk/pdbsum/7aa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aa0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A detailed understanding of the interactions between small-molecule ligands and their proposed binding targets is of the utmost importance for modern drug-development programs. Cellular retinoic acid-binding proteins I and II (CRABPI and CRABPII) facilitate a number of vital retinoid signalling pathways in mammalian cells and offer a gateway to manipulation of signalling that could potentially reduce phenotypes in serious diseases, including cancer and neurodegeneration. Although structurally very similar, the two proteins possess distinctly different biological functions, with their signalling influence being exerted through both genomic and nongenomic pathways. In this article, crystal structures are presented of the L29C mutant of Homo sapiens CRABPI in complex with naturally occurring fatty acids (1.64 A resolution) and with the synthetic retinoid DC645 (2.41 A resolution), and of CRABPII in complex with the ligands DC479 (1.80 A resolution) and DC645 (1.71 A resolution). DC645 and DC479 are two potential drug compounds identified in a recent synthetic retinoid development program. In particular, DC645 has recently been shown to have disease-modifying capabilities in neurodegenerative disease models by activating both genomic and nongenomic signalling pathways. These co-crystal structures demonstrate a canonical binding behaviour akin to that exhibited with all-trans-retinoic acid and help to explain how the compounds are able to exert an influence on part of the retinoid signalling cascade.
		+
		+	Structure-functional relationship of cellular retinoic acid-binding proteins I and II interacting with natural and synthetic ligands.,Tomlinson CWE, Cornish KAS, Whiting A, Pohl E Acta Crystallogr D Struct Biol. 2021 Feb 1;77(Pt 2):164-175. doi: , 10.1107/S2059798320015247. Epub 2021 Feb 5. PMID:33559606<ref>PMID:33559606</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7aa0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cellular retinoic acid-binding protein 3D structures\|Cellular retinoic acid-binding protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cornish KAS]]		[[Category: Cornish KAS]]
	[[Category: Pohl E]]		[[Category: Pohl E]]
	[[Category: Tomlinson CWE]]		[[Category: Tomlinson CWE]]

OCA at 10:00, 17 February 2021

OCA — Wed, 17 Feb 2021 10:00:18 GMT

←Older revision		Revision as of 10:00, 17 February 2021
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-	'''Unreleased structure'''

-	~~The entry 7aa0 is ON HOLD until Paper Publication~~	+	==Structural comparison of cellular retinoic acid binding protein I and II in the presence and absence of natural and synthetic ligands==
-		+	<StructureSection load='7aa0' size='340' side='right'caption='[[7aa0]]' scene=''>
-	~~Authors: Tomlinson, C.W.E., Cornish, K.A.S., Pohl, E.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AA0 FirstGlance]. <br>
-	~~Description:~~ Structural comparison of cellular retinoic acid binding protein I and II in the presence and absence of natural and synthetic ligands	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aa0 OCA], [https://pdbe.org/7aa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aa0 RCSB], [https://www.ebi.ac.uk/pdbsum/7aa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aa0 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Pohl, E~~]]	+	__TOC__
-	[[Category: ~~Cornish, K.A.S~~]]	+	</StructureSection>
-	[[Category: Tomlinson~~, C.W.E~~]]	+	[[Category: Large Structures]]
		+	[[Category: Cornish KAS]]
		+	[[Category: Pohl E]]
		+	[[Category: Tomlinson CWE]]

OCA at 08:39, 23 September 2020

OCA — Wed, 23 Sep 2020 08:39:10 GMT

←Older revision		Revision as of 08:39, 23 September 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7aa0 is ON HOLD	+	The entry 7aa0 is ON HOLD until Paper Publication

	Authors: Tomlinson, C.W.E., Cornish, K.A.S., Pohl, E.		Authors: Tomlinson, C.W.E., Cornish, K.A.S., Pohl, E.

OCA: Protected "7aa0" [edit=sysop:move=sysop]

OCA — Wed, 09 Sep 2020 07:22:54 GMT

Protected "7aa0" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 9 September 2020

OCA: New page: '''Unreleased structure''' The entry 7aa0 is ON HOLD Authors: Tomlinson, C.W.E., Cornish, K.A.S., Pohl, E. Description: Structural comparison of cellular retinoic acid binding protein ...

OCA — Wed, 09 Sep 2020 07:22:50 GMT

New page: '''Unreleased structure''' The entry 7aa0 is ON HOLD Authors: Tomlinson, C.W.E., Cornish, K.A.S., Pohl, E. Description: Structural comparison of cellular retinoic acid binding protein ...

New page

'''Unreleased structure'''

The entry 7aa0 is ON HOLD

Authors: Tomlinson, C.W.E., Cornish, K.A.S., Pohl, E.

Description: Structural comparison of cellular retinoic acid binding protein I and II in the presence and absence of natural and synthetic ligands
[[Category: Unreleased Structures]]
[[Category: Pohl, E]]
[[Category: Cornish, K.A.S]]
[[Category: Tomlinson, C.W.E]]