7al0 - Revision history

OCA at 09:06, 5 May 2021

OCA — Wed, 05 May 2021 09:06:43 GMT

←Older revision		Revision as of 09:06, 5 May 2021
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7al0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7al0 OCA], [https://pdbe.org/7al0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7al0 RCSB], [https://www.ebi.ac.uk/pdbsum/7al0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7al0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7al0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7al0 OCA], [https://pdbe.org/7al0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7al0 RCSB], [https://www.ebi.ac.uk/pdbsum/7al0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7al0 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antimicrobial peptides form part of the innate immune response and play a vital role in host defense against pathogens. Here we report a new antimicrobial peptide belonging to the cathelicidin family, cathelicidin-MH (cath-MH), from the skin of Microhyla heymonsivogt frog. Cath-MH has a single alpha-helical structure in membrane-mimetic environments and is antimicrobial against fungi and bacteria, especially Gram-negative bacteria. In contrast to other cathelicidins, cath-MH suppresses coagulation by affecting the enzymatic activities of tissue plasminogen activator, plasmin, beta-tryptase, elastase, thrombin, and chymase. Cath-MH protects against lipopolysaccharide (LPS)- and cecal ligation and puncture-induced sepsis, effectively ameliorating multiorgan pathology and inflammatory cytokine through its antimicrobial, LPS-neutralizing, coagulation suppressing effects as well as suppression of MAPK signaling. Taken together, these data suggest that cath-MH is an attractive candidate therapeutic agent for the treatment of septic shock.
		+
		+	Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties.,Chai J, Chen X, Ye T, Zeng B, Zeng Q, Wu J, Kascakova B, Martins LA, Prudnikova T, Smatanova IK, Kotsyfakis M, Xu X Elife. 2021 Apr 20;10. pii: 64411. doi: 10.7554/eLife.64411. PMID:33875135<ref>PMID:33875135</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7al0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:30, 28 April 2021

OCA — Wed, 28 Apr 2021 05:30:45 GMT

←Older revision		Revision as of 05:30, 28 April 2021
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	==Crystal Structure of Heymonin, a Novel Frog-derived Peptide==		==Crystal Structure of Heymonin, a Novel Frog-derived Peptide==
-	<StructureSection load='7al0' size='340' side='right'caption='[[7al0]]' scene=''>	+	<StructureSection load='7al0' size='340' side='right'caption='[[7al0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AL0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7al0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Microhyla_heymonsi Microhyla heymonsi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AL0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7al0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7al0 OCA], [https://pdbe.org/7al0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7al0 RCSB], [https://www.ebi.ac.uk/pdbsum/7al0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7al0 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7al0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7al0 OCA], [https://pdbe.org/7al0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7al0 RCSB], [https://www.ebi.ac.uk/pdbsum/7al0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7al0 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kascakova B~~]]	+	[[Category: Microhyla heymonsi]]
-	[[Category: ~~Kuta Smatanova I~~]]	+	[[Category: Kascakova, B]]
-	[[Category: Prudnikova T]]	+	[[Category: Prudnikova, T]]
-	[[Category: Xu X]]	+	[[Category: Smatanova, I Kuta]]
		+	[[Category: Xu, X]]
		+	[[Category: Antimicrobial peptide]]
		+	[[Category: Antimicrobial protein]]
		+	[[Category: Inflammation]]
		+	[[Category: Microhyla heymonsivogt]]

OCA at 08:21, 21 April 2021

OCA — Wed, 21 Apr 2021 08:21:26 GMT

←Older revision		Revision as of 08:21, 21 April 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7al0 ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of Heymonin, a Novel Frog-derived Peptide==
-		+	<StructureSection load='7al0' size='340' side='right'caption='[[7al0]]' scene=''>
-	~~Authors~~: ~~Kascakova~~, B., ~~Prudnikova~~, T., ~~Kuta Smatanova~~, I.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AL0 FirstGlance]. <br>
-	~~Description: Crystal Structure of Heymonin, a Novel Frog-derived Peptide~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7al0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7al0 OCA], [https://pdbe.org/7al0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7al0 RCSB], [https://www.ebi.ac.uk/pdbsum/7al0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7al0 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Kuta Smatanova, I]]	+	__TOC__
-	[[Category: ~~Kascakova, B~~]]	+	</StructureSection>
-	[[Category: ~~Prudnikova, T~~]]	+	[[Category: Large Structures]]
		+	[[Category: Kascakova B]]
		+	[[Category: Kuta Smatanova I]]
		+	[[Category: Prudnikova T]]
		+	[[Category: Xu X]]

OCA: Protected "7al0" [edit=sysop:move=sysop]

OCA — Wed, 14 Oct 2020 04:02:56 GMT

Protected "7al0" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:02, 14 October 2020

OCA: New page: '''Unreleased structure''' The entry 7al0 is ON HOLD until Paper Publication Authors: Kascakova, B., Prudnikova, T., Kuta Smatanova, I. Description: Crystal Structure of Heymonin, a No...

OCA — Wed, 14 Oct 2020 04:02:55 GMT

New page: '''Unreleased structure''' The entry 7al0 is ON HOLD until Paper Publication Authors: Kascakova, B., Prudnikova, T., Kuta Smatanova, I. Description: Crystal Structure of Heymonin, a No...

New page

'''Unreleased structure'''

The entry 7al0 is ON HOLD until Paper Publication

Authors: Kascakova, B., Prudnikova, T., Kuta Smatanova, I.

Description: Crystal Structure of Heymonin, a Novel Frog-derived Peptide
[[Category: Unreleased Structures]]
[[Category: Kuta Smatanova, I]]
[[Category: Kascakova, B]]
[[Category: Prudnikova, T]]