OCA at 07:45, 1 May 2024

OCA — Wed, 01 May 2024 07:45:48 GMT

←Older revision		Revision as of 07:45, 1 May 2024
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-	====	+	==Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2.==
-	<StructureSection load='7at8' size='340' side='right'caption='[[7at8]]' scene=''>	+	<StructureSection load='7at8' size='340' side='right'caption='[[7at8]], [[Resolution\|resolution]] 4.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7at8]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AT8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7at8 OCA], [~~http~~://pdbe.org/7at8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7at8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7at8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7at8 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7at8 OCA], [https://pdbe.org/7at8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7at8 RCSB], [https://www.ebi.ac.uk/pdbsum/7at8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7at8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN] Weaver syndrome. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN] Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA.<ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16179254</ref> <ref>PMID:16618801</ref> <ref>PMID:16357870</ref> <ref>PMID:16936726</ref> <ref>PMID:17210787</ref> <ref>PMID:17344414</ref> <ref>PMID:19026781</ref> <ref>PMID:18285464</ref> <ref>PMID:20935635</ref> <ref>PMID:23063525</ref>
		+
		+	==See Also==
		+	*[[Histone 3D structures\|Histone 3D structures]]
		+	*[[Polycomb complex proteins 3D structures\|Polycomb complex proteins 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Xenopus laevis]]
		+	[[Category: Benda C]]
		+	[[Category: Finogenova K]]
		+	[[Category: Mueller J]]
		+	[[Category: Poepsel S]]
		+	[[Category: Schaefer IB]]
		+	[[Category: Strauss M]]

OCA at 06:39, 9 December 2020

OCA — Wed, 09 Dec 2020 06:39:55 GMT

←Older revision		Revision as of 06:39, 9 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7at8 ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7at8' size='340' side='right'caption='[[7at8]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7at8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7at8 OCA], [http://pdbe.org/7at8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7at8 RCSB], [http://www.ebi.ac.uk/pdbsum/7at8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7at8 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7at8" [edit=sysop:move=sysop]

OCA — Wed, 04 Nov 2020 05:25:44 GMT

Protected "7at8" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:25, 4 November 2020

OCA: New page: '''Unreleased structure''' The entry 7at8 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Nov 2020 05:25:43 GMT

New page: '''Unreleased structure''' The entry 7at8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7at8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7at8 - Revision history

OCA at 07:45, 1 May 2024

OCA at 06:39, 9 December 2020

OCA: Protected "7at8" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7at8 is ON HOLD Authors: Description: Category: Unreleased Structures