7ats - Revision history

OCA at 12:15, 1 February 2024

OCA — Thu, 01 Feb 2024 12:15:55 GMT

←Older revision		Revision as of 12:15, 1 February 2024
Line 1:		Line 1:

	==The LIMK1 Kinase Domain Bound To LIJTF500127==		==The LIMK1 Kinase Domain Bound To LIJTF500127==
-	<StructureSection load='7ats' size='340' side='right'caption='[[7ats]]' scene=''>	+	<StructureSection load='7ats' size='340' side='right'caption='[[7ats]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ATS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7ATS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ats]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ATS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ATS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7ats FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ats OCA], [~~http~~://pdbe.org/7ats PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7ats RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7ats PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7ats ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RXQ:N-[3-[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]benzenesulfonamide'>RXQ</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ats FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ats OCA], [https://pdbe.org/7ats PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ats RCSB], [https://www.ebi.ac.uk/pdbsum/7ats PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ats ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN] Williams syndrome. Note=LIMK1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LIMK1_HUMAN LIMK1_HUMAN] Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.<ref>PMID:10196227</ref> <ref>PMID:10436159</ref> <ref>PMID:11832213</ref> <ref>PMID:12807904</ref> <ref>PMID:15660133</ref> <ref>PMID:16230460</ref> <ref>PMID:18028908</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ahmed M]]		[[Category: Ahmed M]]

OCA at 06:57, 25 November 2020

OCA — Wed, 25 Nov 2020 06:57:53 GMT

←Older revision		Revision as of 06:57, 25 November 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 7ats ~~is ON HOLD~~	+	==The LIMK1 Kinase Domain Bound To LIJTF500127==
-		+	<StructureSection load='7ats' size='340' side='right'caption='[[7ats]]' scene=''>
-	~~Authors~~: ~~Mathea, S~~.~~, Chatterjee, D~~.~~, Preuss, F~~.~~, Yamamoto, S~~., ~~Tawada, M~~., ~~Nomura, I~~., ~~Takagi, T~~., ~~Ahmed, M~~., ~~Little, W~~.~~, Mueller~~-~~Knapp, S., Knapp, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ATS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7ATS FirstGlance]. <br>
-	~~Description: The LIMK1 Kinase Domain Bound To LIJTF500127~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ats FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ats OCA], [http://pdbe.org/7ats PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ats RCSB], [http://www.ebi.ac.uk/pdbsum/7ats PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ats ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Yamamoto, S~~]]	+	__TOC__
-	[[Category: ~~Ahmed, M~~]]	+	</StructureSection>
-	[[Category: ~~Takagi, T~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Chatterjee, D~~]]	+	[[Category: Ahmed M]]
-	[[Category: ~~Nomura, I~~]]	+	[[Category: Chatterjee D]]
-	[[Category: ~~Little, W~~]]	+	[[Category: Knapp S]]
-	[[Category: ~~Tawada, M~~]]	+	[[Category: Little W]]
-	[[Category: ~~Knapp, S~~]]	+	[[Category: Mathea S]]
-	[[Category: ~~Preuss, F~~]]	+	[[Category: Mueller-Knapp S]]
-	[[Category: ~~Mathea, S~~]]	+	[[Category: Nomura I]]
-	[[Category: ~~Mueller-Knapp,~~ S]]	+	[[Category: Preuss F]]
		+	[[Category: Takagi T]]
		+	[[Category: Tawada M]]
		+	[[Category: Yamamoto S]]

OCA: Protected "7ats" [edit=sysop:move=sysop]

OCA — Wed, 11 Nov 2020 06:16:05 GMT

Protected "7ats" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:16, 11 November 2020

OCA: New page: '''Unreleased structure''' The entry 7ats is ON HOLD Authors: Mathea, S., Chatterjee, D., Preuss, F., Yamamoto, S., Tawada, M., Nomura, I., Takagi, T., Ahmed, M., Little, W., Mueller-Kn...

OCA — Wed, 11 Nov 2020 06:16:04 GMT

New page: '''Unreleased structure''' The entry 7ats is ON HOLD Authors: Mathea, S., Chatterjee, D., Preuss, F., Yamamoto, S., Tawada, M., Nomura, I., Takagi, T., Ahmed, M., Little, W., Mueller-Kn...

New page

'''Unreleased structure'''

The entry 7ats is ON HOLD

Authors: Mathea, S., Chatterjee, D., Preuss, F., Yamamoto, S., Tawada, M., Nomura, I., Takagi, T., Ahmed, M., Little, W., Mueller-Knapp, S., Knapp, S.

Description: The LIMK1 Kinase Domain Bound To LIJTF500127
[[Category: Unreleased Structures]]
[[Category: Yamamoto, S]]
[[Category: Ahmed, M]]
[[Category: Takagi, T]]
[[Category: Chatterjee, D]]
[[Category: Nomura, I]]
[[Category: Little, W]]
[[Category: Tawada, M]]
[[Category: Knapp, S]]
[[Category: Preuss, F]]
[[Category: Mathea, S]]
[[Category: Mueller-Knapp, S]]