7axz - Revision history

OCA at 07:46, 1 May 2024

OCA — Wed, 01 May 2024 07:46:13 GMT

←Older revision		Revision as of 07:46, 1 May 2024
Line 1:		Line 1:

-	====	+	==Ku70/80 complex apo form==
-	<StructureSection load='7axz' size='340' side='right'caption='[[7axz]]' scene=''>	+	<StructureSection load='7axz' size='340' side='right'caption='[[7axz]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7axz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AXZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7axz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7axz OCA], [https://pdbe.org/7axz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7axz RCSB], [https://www.ebi.ac.uk/pdbsum/7axz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7axz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7axz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7axz OCA], [https://pdbe.org/7axz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7axz RCSB], [https://www.ebi.ac.uk/pdbsum/7axz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7axz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/XRCC6_HUMAN XRCC6_HUMAN] Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.<ref>PMID:2466842</ref> <ref>PMID:8621488</ref> <ref>PMID:7957065</ref> <ref>PMID:9742108</ref> <ref>PMID:12145306</ref> <ref>PMID:20493174</ref> <ref>PMID:20383123</ref>
		+
		+	==See Also==
		+	*[[Ku protein\|Ku protein]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Blundell TL]]
		+	[[Category: Hnizda A]]
		+	[[Category: Novak P]]
		+	[[Category: Tesina P]]

OCA at 10:58, 10 February 2021

OCA — Wed, 10 Feb 2021 10:58:37 GMT

←Older revision		Revision as of 10:58, 10 February 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7axz ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7axz' size='340' side='right'caption='[[7axz]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7axz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7axz OCA], [https://pdbe.org/7axz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7axz RCSB], [https://www.ebi.ac.uk/pdbsum/7axz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7axz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:10, 3 February 2021

OCA — Wed, 03 Feb 2021 09:10:37 GMT

←Older revision		Revision as of 09:10, 3 February 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7axz is ON HOLD ~~until Paper Publication~~	+	The entry 7axz is ON HOLD

	Authors:		Authors:

OCA at 04:58, 9 December 2020

OCA — Wed, 09 Dec 2020 04:58:35 GMT

←Older revision		Revision as of 04:58, 9 December 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7axz is ON HOLD	+	The entry 7axz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7axz" [edit=sysop:move=sysop]

OCA — Wed, 18 Nov 2020 07:56:30 GMT

Protected "7axz" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:56, 18 November 2020

OCA: New page: '''Unreleased structure''' The entry 7axz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Nov 2020 07:56:29 GMT

New page: '''Unreleased structure''' The entry 7axz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7axz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]