7b5o - Revision history

OCA at 07:47, 1 May 2024

OCA — Wed, 01 May 2024 07:47:39 GMT

←Older revision		Revision as of 07:47, 1 May 2024
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-	====	+	==Cryo-EM structure of the human CAK bound to ICEC0942 at 2.5 Angstroms resolution==
-	<StructureSection load='7b5o' size='340' side='right'caption='[[7b5o]]' scene=''>	+	<StructureSection load='7b5o' size='340' side='right'caption='[[7b5o]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7b5o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B5O FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b5o OCA], [https://pdbe.org/7b5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b5o RCSB], [https://www.ebi.ac.uk/pdbsum/7b5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b5o ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I74:(3R,4R)-4-[[[7-[(PHENYLMETHYL)AMINO]-3-PROPAN-2-YL-PYRAZOLO[1,5-A]PYRIMIDIN-5-YL]AMINO]METHYL]PIPERIDIN-3-OL'>I74</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b5o OCA], [https://pdbe.org/7b5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b5o RCSB], [https://www.ebi.ac.uk/pdbsum/7b5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b5o ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref>
		+
		+	==See Also==
		+	*[[Cyclin 3D structures\|Cyclin 3D structures]]
		+	*[[Cyclin-dependent kinase 3D structures\|Cyclin-dependent kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Ali S]]
		+	[[Category: Greber BJ]]
		+	[[Category: Nogales E]]
		+	[[Category: Remis J]]

OCA at 10:59, 10 February 2021

OCA — Wed, 10 Feb 2021 10:59:45 GMT

←Older revision		Revision as of 10:59, 10 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7b5o ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7b5o' size='340' side='right'caption='[[7b5o]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b5o OCA], [https://pdbe.org/7b5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b5o RCSB], [https://www.ebi.ac.uk/pdbsum/7b5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b5o ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 07:35, 24 December 2020

OCA — Thu, 24 Dec 2020 07:35:34 GMT

←Older revision		Revision as of 07:35, 24 December 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7b5o is ON HOLD	+	The entry 7b5o is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7b5o" [edit=sysop:move=sysop]

OCA — Wed, 16 Dec 2020 10:58:17 GMT

Protected "7b5o" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:58, 16 December 2020

OCA: New page: '''Unreleased structure''' The entry 7b5o is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Dec 2020 10:58:16 GMT

New page: '''Unreleased structure''' The entry 7b5o is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7b5o is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]