7b7t - Revision history

OCA at 12:23, 1 February 2024

OCA — Thu, 01 Feb 2024 12:23:09 GMT

←Older revision		Revision as of 12:23, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7b7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans_Z-2901 Carboxydothermus hydrogenoformans Z-2901]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B7T FirstGlance]. <br>		<table><tr><td colspan='2'>[[7b7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans_Z-2901 Carboxydothermus hydrogenoformans Z-2901]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B7T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SF3:FE4-S3+CLUSTER'>SF3</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.38Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SF3:FE4-S3+CLUSTER'>SF3</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b7t OCA], [https://pdbe.org/7b7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b7t RCSB], [https://www.ebi.ac.uk/pdbsum/7b7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b7t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b7t OCA], [https://pdbe.org/7b7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b7t RCSB], [https://www.ebi.ac.uk/pdbsum/7b7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b7t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q3AG28_CARHZ Q3AG28_CARHZ]]	+	[https://www.uniprot.org/uniprot/Q3AG28_CARHZ Q3AG28_CARHZ]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7b7t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7b7t" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbon monoxide dehydrogenase 3D structures\|Carbon monoxide dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:35, 8 September 2022

OCA — Thu, 08 Sep 2022 04:35:21 GMT

←Older revision		Revision as of 04:35, 8 September 2022
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	<StructureSection load='7b7t' size='340' side='right'caption='[[7b7t]], [[Resolution\|resolution]] 1.38Å' scene=''>		<StructureSection load='7b7t' size='340' side='right'caption='[[7b7t]], [[Resolution\|resolution]] 1.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7b7t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7b7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Carboxydothermus_hydrogenoformans_Z-2901 Carboxydothermus hydrogenoformans Z-2901]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B7T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SF3:FE4-S3+CLUSTER'>SF3</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SF3:FE4-S3+CLUSTER'>SF3</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Anaerobic_carbon-monoxide_dehydrogenase Anaerobic carbon-monoxide dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.4 1.2.7.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b7t OCA], [https://pdbe.org/7b7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b7t RCSB], [https://www.ebi.ac.uk/pdbsum/7b7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b7t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b7t OCA], [https://pdbe.org/7b7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b7t RCSB], [https://www.ebi.ac.uk/pdbsum/7b7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b7t ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q3AG28_CARHZ Q3AG28_CARHZ]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anaerobic carbon~~-~~monoxide dehydrogenase~~]]	+	[[Category: Carboxydothermus hydrogenoformans Z-2901]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dobbek, H]]	+	[[Category: Dobbek H]]
-	[[Category: Jeoung~~, J H]]~~	+	[[Category: Jeoung JH]]
-	~~[[Category: Codh]]~~	+
-	~~[[Category: Hcp]]~~	+
-	~~[[Category: Hybrid cluster]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 18:09, 27 July 2022

OCA — Wed, 27 Jul 2022 18:09:28 GMT

←Older revision		Revision as of 18:09, 27 July 2022
Line 1:		Line 1:

	==CooS-V with oxidized hybrid cluster==		==CooS-V with oxidized hybrid cluster==
-	<StructureSection load='7b7t' size='340' side='right'caption='[[7b7t]]' scene=''>	+	<StructureSection load='7b7t' size='340' side='right'caption='[[7b7t]], [[Resolution\|resolution]] 1.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7b7t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B7T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b7t OCA], [https://pdbe.org/7b7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b7t RCSB], [https://www.ebi.ac.uk/pdbsum/7b7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b7t ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SF3:FE4-S3+CLUSTER'>SF3</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Anaerobic_carbon-monoxide_dehydrogenase Anaerobic carbon-monoxide dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.4 1.2.7.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b7t OCA], [https://pdbe.org/7b7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b7t RCSB], [https://www.ebi.ac.uk/pdbsum/7b7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b7t ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ni,Fe-containing carbon monoxide dehydrogenases (CODHs) catalyze the reversible reduction of CO2 to CO. Several anaerobic microorganisms encode multiple CODHs in their genome, of which some, despite being annotated as CODHs, lack a cysteine of the canonical binding motif for the active site Ni,Fe-cluster. Here, we report on the structure and reactivity of such a deviant enzyme, termed CooS-VCh . Its structure reveals the typical CODH scaffold, but contains an iron-sulfur-oxo hybrid-cluster. Although closely related to true CODHs, CooS-VCh catalyzes neither CO oxidation, nor CO2 reduction. The active site of CooS-VCh undergoes a redox-dependent restructuring between a reduced [4Fe-3S]-cluster and an oxidized [4Fe-2S-S*-2O-2(H2 O)]-cluster. Hydroxylamine, a slow-turnover substrate of CooS-VCh , oxidizes the hybrid-cluster in two structurally distinct steps. Overall, minor changes in CODHs are sufficient to accommodate a Fe/S/O-cluster in place of the Ni,Fe-heterocubane-cluster of CODHs.
		+
		+	A Morphing [4Fe-3S-nO]-Cluster within a Carbon Monoxide Dehydrogenase Scaffold.,Jeoung JH, Fesseler J, Domnik L, Klemke F, Sinnreich M, Teutloff C, Dobbek H Angew Chem Int Ed Engl. 2022 Apr 25;61(18):e202117000. doi:, 10.1002/anie.202117000. Epub 2022 Mar 4. PMID:35133707<ref>PMID:35133707</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7b7t" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Anaerobic carbon-monoxide dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dobbek H]]	+	[[Category: Dobbek, H]]
-	[[Category: Jeoung JH]]	+	[[Category: Jeoung, J H]]
		+	[[Category: Codh]]
		+	[[Category: Hcp]]
		+	[[Category: Hybrid cluster]]
		+	[[Category: Oxidoreductase]]

OCA at 09:53, 12 January 2022

OCA — Wed, 12 Jan 2022 09:53:42 GMT

←Older revision		Revision as of 09:53, 12 January 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7b7t ~~is ON HOLD~~	+	==CooS-V with oxidized hybrid cluster==
-		+	<StructureSection load='7b7t' size='340' side='right'caption='[[7b7t]]' scene=''>
-	~~Authors~~: ~~Jeoung~~, J.H., ~~Dobbek~~, H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B7T FirstGlance]. <br>
-	~~Description~~: ~~CooS~~-~~V with oxidized hybrid cluster~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b7t OCA], [https://pdbe.org/7b7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b7t RCSB], [https://www.ebi.ac.uk/pdbsum/7b7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b7t ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Dobbek, H]]	+	__TOC__
-	[[Category: Jeoung~~, J.H~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Dobbek H]]
		+	[[Category: Jeoung JH]]

OCA: Protected "7b7t" [edit=sysop:move=sysop]

OCA — Thu, 24 Dec 2020 07:36:41 GMT

Protected "7b7t" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:36, 24 December 2020

OCA: New page: '''Unreleased structure''' The entry 7b7t is ON HOLD Authors: Jeoung, J.H., Dobbek, H. Description: CooS-V with oxidized hybrid cluster Category: Unreleased Structures [[Category: ...

OCA — Thu, 24 Dec 2020 07:36:39 GMT

New page: '''Unreleased structure''' The entry 7b7t is ON HOLD Authors: Jeoung, J.H., Dobbek, H. Description: CooS-V with oxidized hybrid cluster Category: Unreleased Structures [[Category: ...

New page

'''Unreleased structure'''

The entry 7b7t is ON HOLD

Authors: Jeoung, J.H., Dobbek, H.

Description: CooS-V with oxidized hybrid cluster
[[Category: Unreleased Structures]]
[[Category: Dobbek, H]]
[[Category: Jeoung, J.H]]