OCA at 12:24, 1 February 2024

OCA — Thu, 01 Feb 2024 12:24:36 GMT

←Older revision		Revision as of 12:24, 1 February 2024
Line 1:		Line 1:

-	====	+	==Cys-42-tethered stabilizer 7 of 14-3-3(sigma)/ERa PPI==
-	<StructureSection load='7ba5' size='340' side='right'caption='[[7ba5]]' scene=''>	+	<StructureSection load='7ba5' size='340' side='right'caption='[[7ba5]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ba5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BA5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ba5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ba5 OCA], [https://pdbe.org/7ba5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ba5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ba5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ba5 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T5T:2-(4-fluoranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide'>T5T</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ba5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ba5 OCA], [https://pdbe.org/7ba5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ba5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ba5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ba5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The systematic discovery of functional fragments binding to the composite interface of protein complexes is a first critical step for the development of orthosteric stabilizers of protein-protein interactions (PPIs). We have previously shown that disulfide trapping successfully yielded covalent stabilizers for the PPI of 14-3-3 with the estrogen receptor ERalpha. Here we provide an assessment of the composite PPI target pocket and the molecular characteristics of various fragments binding to a specific subpocket. Evaluating structure-activity relationships highlights the basic principles for PPI stabilization by these covalent fragments that engage a relatively large and exposed binding pocket at the protein/peptide interface with a "molecular glue" mode of action.
		+
		+	Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers.,Sijbesma E, Hallenbeck KK, Andrei SA, Rust RR, Adriaans JMC, Brunsveld L, Arkin MR, Ottmann C ACS Med Chem Lett. 2021 May 10;12(6):976-982. doi: , 10.1021/acsmedchemlett.1c00088. eCollection 2021 Jun 10. PMID:34136078<ref>PMID:34136078</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ba5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Ottmann C]]
		+	[[Category: Sijbesma E]]

OCA at 09:55, 7 July 2021

OCA — Wed, 07 Jul 2021 09:55:10 GMT

←Older revision		Revision as of 09:55, 7 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ba5 ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7ba5' size='340' side='right'caption='[[7ba5]]' scene=''>
-	~~Authors~~: ~~Sijbesma, E~~.~~, Ottmann, C~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Cys-42~~-~~tethered stabilizer 7 of 14-3-3(sigma)~~/~~ERa PPI~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ba5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ba5 OCA], [https://pdbe.org/7ba5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ba5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ba5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ba5 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Ottmann, C~~]]	+	__TOC__
-	[[Category: ~~Sijbesma, E~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7ba5" [edit=sysop:move=sysop]

OCA — Thu, 24 Dec 2020 07:45:05 GMT

Protected "7ba5" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:45, 24 December 2020

OCA: New page: '''Unreleased structure''' The entry 7ba5 is ON HOLD Authors: Sijbesma, E., Ottmann, C. Description: Cys-42-tethered stabilizer 7 of 14-3-3(sigma)/ERa PPI [[Category: Unreleased Struct...

OCA — Thu, 24 Dec 2020 07:45:03 GMT

New page: '''Unreleased structure''' The entry 7ba5 is ON HOLD Authors: Sijbesma, E., Ottmann, C. Description: Cys-42-tethered stabilizer 7 of 14-3-3(sigma)/ERa PPI [[Category: Unreleased Struct...

New page

'''Unreleased structure'''

The entry 7ba5 is ON HOLD

Authors: Sijbesma, E., Ottmann, C.

Description: Cys-42-tethered stabilizer 7 of 14-3-3(sigma)/ERa PPI
[[Category: Unreleased Structures]]
[[Category: Ottmann, C]]
[[Category: Sijbesma, E]]

7ba5 - Revision history

OCA at 12:24, 1 February 2024

OCA at 09:55, 7 July 2021

OCA: Protected "7ba5" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ba5 is ON HOLD Authors: Sijbesma, E., Ottmann, C. Description: Cys-42-tethered stabilizer 7 of 14-3-3(sigma)/ERa PPI [[Category: Unreleased Struct...