7bic - Revision history

OCA at 12:28, 1 February 2024

OCA — Thu, 01 Feb 2024 12:28:54 GMT

←Older revision		Revision as of 12:28, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7bic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BIC FirstGlance]. <br>		<table><tr><td colspan='2'>[[7bic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BIC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9AI:N-PROP-2-EN-1-YLTHIOFORMAMIDE'>9AI</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.46Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9AI:N-PROP-2-EN-1-YLTHIOFORMAMIDE'>9AI</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bic OCA], [https://pdbe.org/7bic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bic RCSB], [https://www.ebi.ac.uk/pdbsum/7bic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bic ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bic OCA], [https://pdbe.org/7bic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bic RCSB], [https://www.ebi.ac.uk/pdbsum/7bic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bic ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>	+	[https://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:00, 14 September 2022

OCA — Wed, 14 Sep 2022 07:00:35 GMT

←Older revision		Revision as of 07:00, 14 September 2022
Line 1:		Line 1:

	==Crystal structure of human GSTA1-1 bound to allyl-isothiocyanate==		==Crystal structure of human GSTA1-1 bound to allyl-isothiocyanate==
-	<StructureSection load='7bic' size='340' side='right'caption='[[7bic]]' scene=''>	+	<StructureSection load='7bic' size='340' side='right'caption='[[7bic]], [[Resolution\|resolution]] 2.46Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BIC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BIC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bic OCA], [https://pdbe.org/7bic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bic RCSB], [https://www.ebi.ac.uk/pdbsum/7bic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bic ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9AI:N-PROP-2-EN-1-YLTHIOFORMAMIDE'>9AI</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bic OCA], [https://pdbe.org/7bic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bic RCSB], [https://www.ebi.ac.uk/pdbsum/7bic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bic ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molecules that elicit taste sensation are perceived by interacting with the taste receptors located in the taste buds. Enzymes involved in the detoxification processes are found in saliva as well as in type II cells, where taste receptors, including bitter taste receptors, are located. These enzymes are known to interact with a large panel of molecules. To explore a possible link between these enzymes and bitter taste perception, we demonstrate that salivary glutathione transferases (GSTA1 and GSTP1) can metabolize bitter molecules. To support these abilities, we solve three X-ray structures of these enzymes in complexes with isothiocyanates. Salivary GSTA1 and GSTP1 are expressed in a large panel of subjects. Additionally, GSTA1 levels in the saliva of people suffering from taste disorders are significantly lower than those in the saliva of the control group.
		+
		+	Role of human salivary enzymes in bitter taste perception.,Schwartz M, Brignot H, Feron G, Hummel T, Zhu Y, von Koskull D, Heydel JM, Lirussi F, Canon F, Neiers F Food Chem. 2022 Aug 30;386:132798. doi: 10.1016/j.foodchem.2022.132798. Epub 2022, Mar 23. PMID:35344726<ref>PMID:35344726</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7bic" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Neiers F]]		[[Category: Neiers F]]
	[[Category: Schwartz M]]		[[Category: Schwartz M]]

OCA at 06:14, 2 March 2022

OCA — Wed, 02 Mar 2022 06:14:43 GMT

←Older revision		Revision as of 06:14, 2 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7bic ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of human GSTA1-1 bound to allyl-isothiocyanate==
-		+	<StructureSection load='7bic' size='340' side='right'caption='[[7bic]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BIC FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bic OCA], [https://pdbe.org/7bic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bic RCSB], [https://www.ebi.ac.uk/pdbsum/7bic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bic ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Neiers F]]
		+	[[Category: Schwartz M]]

OCA at 13:07, 3 March 2021

OCA — Wed, 03 Mar 2021 13:07:53 GMT

←Older revision		Revision as of 13:07, 3 March 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7bic is ON HOLD	+	The entry 7bic is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7bic" [edit=sysop:move=sysop]

OCA — Wed, 20 Jan 2021 06:41:57 GMT

Protected "7bic" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:41, 20 January 2021

OCA: New page: '''Unreleased structure''' The entry 7bic is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jan 2021 06:41:56 GMT

New page: '''Unreleased structure''' The entry 7bic is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7bic is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]