OCA at 15:26, 29 November 2023

OCA — Wed, 29 Nov 2023 15:26:43 GMT

←Older revision		Revision as of 15:26, 29 November 2023
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-	====	+	==Cereblon in complex with SALL4 and (S)-thalidomide==
-	<StructureSection load='7bqu' size='340' side='right'caption='[[7bqu]]' scene=''>	+	<StructureSection load='7bqu' size='340' side='right'caption='[[7bqu]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BQU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7bqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bqu OCA], [~~http~~://pdbe.org/7bqu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7bqu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7bqu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7bqu ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EF2:S-THALIDOMIDE'>EF2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bqu OCA], [https://pdbe.org/7bqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bqu RCSB], [https://www.ebi.ac.uk/pdbsum/7bqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bqu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Autosomal recessive nonsyndromic intellectual deficit;Distal monosomy 3p. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CRBN_HUMAN CRBN_HUMAN] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.<ref>PMID:18414909</ref> <ref>PMID:20223979</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thalidomide and its derivatives exert not only therapeutic effects as immunomodulatory drugs (IMiDs) but also adverse effects such as teratogenicity, which are due in part to different C2H2 zinc-finger (ZF) transcription factors, IKZF1 (or IKZF3) and SALL4, respectively. Here, we report the structural bases for the SALL4-specific proteasomal degradation induced by 5-hydroxythalidomide, a primary thalidomide metabolite generated by the enzymatic activity of cytochrome P450 isozymes, through the interaction with cereblon (CRBN). The crystal structure of the metabolite-mediated human SALL4-CRBN complex and mutagenesis studies elucidate the complex formation enhanced by the interaction between CRBN and an additional hydroxy group of (S)-5-hydroxythalidomide and the variation in the second residue of beta-hairpin structure that underlies the C2H2 ZF-type neo-morphic substrate (neosubstrate) selectivity of 5-hydroxythalidomide. These findings deepen our understanding of the pharmaceutical action of IMiDs and provide structural evidence that the glue-type E3 ligase modulators cause altered neosubstrate specificities through their metabolism.
		+
		+	Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.,Furihata H, Yamanaka S, Honda T, Miyauchi Y, Asano A, Shibata N, Tanokura M, Sawasaki T, Miyakawa T Nat Commun. 2020 Sep 14;11(1):4578. doi: 10.1038/s41467-020-18488-4. PMID:32929090<ref>PMID:32929090</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7bqu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Asano A]]
		+	[[Category: Furihata H]]
		+	[[Category: Miyakawa T]]
		+	[[Category: Miyauchi Y]]
		+	[[Category: Tanokura M]]

OCA at 11:18, 26 August 2020

OCA — Wed, 26 Aug 2020 11:18:36 GMT

←Older revision		Revision as of 11:18, 26 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7bqu ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7bqu' size='340' side='right'caption='[[7bqu]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bqu OCA], [http://pdbe.org/7bqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bqu RCSB], [http://www.ebi.ac.uk/pdbsum/7bqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bqu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:48, 8 April 2020

OCA — Wed, 08 Apr 2020 05:48:48 GMT

←Older revision		Revision as of 05:48, 8 April 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7bqu is ON HOLD	+	The entry 7bqu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7bqu" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2020 07:56:03 GMT

Protected "7bqu" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:56, 1 April 2020

OCA: New page: '''Unreleased structure''' The entry 7bqu is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Apr 2020 07:56:02 GMT

New page: '''Unreleased structure''' The entry 7bqu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7bqu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7bqu - Revision history

OCA at 15:26, 29 November 2023

OCA at 11:18, 26 August 2020

OCA at 05:48, 8 April 2020

OCA: Protected "7bqu" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7bqu is ON HOLD Authors: Description: Category: Unreleased Structures