7br9 - Revision history

OCA at 15:27, 29 November 2023

OCA — Wed, 29 Nov 2023 15:27:00 GMT

←Older revision		Revision as of 15:27, 29 November 2023
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	==Crystal structure of mus musculus IRG1==		==Crystal structure of mus musculus IRG1==
-	<StructureSection load='7br9' size='340' side='right'caption='[[7br9]]' scene=''>	+	<StructureSection load='7br9' size='340' side='right'caption='[[7br9]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7br9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7br9 OCA], [https://pdbe.org/7br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7br9 RCSB], [https://www.ebi.ac.uk/pdbsum/7br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7br9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7br9 OCA], [https://pdbe.org/7br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7br9 RCSB], [https://www.ebi.ac.uk/pdbsum/7br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7br9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IRG1_MOUSE IRG1_MOUSE] Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:30635240, PubMed:31548418). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240). Plays a role in the embryo implantation (PubMed:14500577).<ref>PMID:14500577</ref> <ref>PMID:23609450</ref> <ref>PMID:23610393</ref> <ref>PMID:30635240</ref> <ref>PMID:31548418</ref> <ref>PMID:35662396</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PROTEIN DATA BANK ACCESSION CODES: Coordinate and structural factors were deposited with the Protein Data Bank under PDB ID: 7BR9.
		+
		+	The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation.,Chun HL, Lee SY, Kim KH, Lee CS, Oh TJ, Park HH PLoS One. 2020 Dec 1;15(12):e0242383. doi: 10.1371/journal.pone.0242383., eCollection 2020. PMID:33259501<ref>PMID:33259501</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7br9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
	[[Category: Chun HL]]		[[Category: Chun HL]]
	[[Category: Park HH]]		[[Category: Park HH]]

OCA at 11:10, 3 February 2021

OCA — Wed, 03 Feb 2021 11:10:15 GMT

←Older revision		Revision as of 11:10, 3 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7br9 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of mus musculus IRG1==
-		+	<StructureSection load='7br9' size='340' side='right'caption='[[7br9]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BR9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7br9 OCA], [https://pdbe.org/7br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7br9 RCSB], [https://www.ebi.ac.uk/pdbsum/7br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7br9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chun HL]]
		+	[[Category: Park HH]]

OCA at 07:58, 18 November 2020

OCA — Wed, 18 Nov 2020 07:58:58 GMT

←Older revision		Revision as of 07:58, 18 November 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7br9 is ON HOLD	+	The entry 7br9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:21, 11 November 2020

OCA — Wed, 11 Nov 2020 06:21:55 GMT

←Older revision		Revision as of 06:21, 11 November 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7br9 is ON HOLD ~~until Paper Publication~~	+	The entry 7br9 is ON HOLD

	Authors:		Authors:

OCA at 05:08, 27 May 2020

OCA — Wed, 27 May 2020 05:08:01 GMT

←Older revision		Revision as of 05:08, 27 May 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7br9 is ON HOLD	+	The entry 7br9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7br9" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2020 07:57:00 GMT

Protected "7br9" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:57, 1 April 2020

OCA: New page: '''Unreleased structure''' The entry 7br9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Apr 2020 07:56:59 GMT

New page: '''Unreleased structure''' The entry 7br9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7br9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]