7bup - Revision history

OCA at 15:35, 29 November 2023

OCA — Wed, 29 Nov 2023 15:35:04 GMT

←Older revision		Revision as of 15:35, 29 November 2023
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	<StructureSection load='7bup' size='340' side='right'caption='[[7bup]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='7bup' size='340' side='right'caption='[[7bup]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7bup]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Canal Canal~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bup]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BUP FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~POL30~~, ~~orf19.4616, CAALFM_C401770WA (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=237561 CANAL])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bup OCA], [https://pdbe.org/7bup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bup RCSB], [https://www.ebi.ac.uk/pdbsum/7bup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bup ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bup OCA], [https://pdbe.org/7bup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bup RCSB], [https://www.ebi.ac.uk/pdbsum/7bup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bup ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q5AMN0_CANAL Q5AMN0_CANAL]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.[RuleBase:RU000641]	+	[https://www.uniprot.org/uniprot/Q5AMN0_CANAL Q5AMN0_CANAL] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.[RuleBase:RU000641]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7bup" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7bup" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Proliferating cell nuclear antigen 3D structures\|Proliferating cell nuclear antigen 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canal~~]]	+	[[Category: Candida albicans SC5314]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Vasudevan, D]]	+	[[Category: Vasudevan D]]
-	[[Category: Sundaram, R]]	+	[[Category: Sundaram R]]
-	~~[[Category: Cell cycle control]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna polymerase processivity factor activity]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Dna replication~~]]	+

OCA at 12:30, 9 June 2021

OCA — Wed, 09 Jun 2021 12:30:59 GMT

←Older revision		Revision as of 12:30, 9 June 2021
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	==Crystal structure of PCNA from pathogenic yeast Candida albicans==		==Crystal structure of PCNA from pathogenic yeast Candida albicans==
-	<StructureSection load='7bup' size='340' side='right'caption='[[7bup]]' scene=''>	+	<StructureSection load='7bup' size='340' side='right'caption='[[7bup]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bup]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BUP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bup OCA], [https://pdbe.org/7bup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bup RCSB], [https://www.ebi.ac.uk/pdbsum/7bup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bup ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, orf19.4616, CAALFM_C401770WA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bup OCA], [https://pdbe.org/7bup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bup RCSB], [https://www.ebi.ac.uk/pdbsum/7bup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bup ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q5AMN0_CANAL Q5AMN0_CANAL]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.[RuleBase:RU000641]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An assembly of multiprotein complexes achieves chromosomal DNA replication at the replication fork. In eukaryotes, proliferating cell nuclear antigen (PCNA) plays a vital role in the assembly of multiprotein complexes at the replication fork and is essential for cell viability. PCNA from several organisms, including Saccharomyces cerevisiae, has been structurally characterised. However, the structural analyses of PCNA from fungal pathogens are limited. Recently, we have reported that PCNA from the opportunistic fungal pathogen Candida albicans complements the essential functions of ScPCNA in S. cerevisiae. Still, it only partially rescues the loss of ScPCNA when the yeast cells are under genotoxic stress. To understand this further, herein, we have determined the crystal structure of CaPCNA and compared that with the existing structures of other fungal and human PCNA. Our comparative structural and in-solution small-angle X-ray scattering (SAXS) analyses reveal that CaPCNA forms a stable homotrimer, both in crystal and in solution. It displays noticeable structural alterations in the oligomerisation interface, P-loop and hydrophobic pocket regions, suggesting its differential function in a heterologous system and avenues for developing specific therapeutics. DATABASES: The PDB and SASBDB accession codes for CaPCNA are 7BUP and SASDHQ9, respectively.
		+
		+	Structural analyses of PCNA from the fungal pathogen Candida albicans identify three regions with species-specific conformations.,Sundaram R, Manohar K, Patel SK, Acharya N, Vasudevan D FEBS Lett. 2021 Jan 10. doi: 10.1002/1873-3468.14055. PMID:33544878<ref>PMID:33544878</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7bup" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Canal]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Vasudevan D]]	+	[[Category: Vasudevan, D]]
-	[[Category: Sundaram R]]	+	[[Category: Sundaram, R]]
		+	[[Category: Cell cycle control]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna polymerase processivity factor activity]]
		+	[[Category: Dna repair]]
		+	[[Category: Dna replication]]

OCA at 10:01, 17 February 2021

OCA — Wed, 17 Feb 2021 10:01:11 GMT

←Older revision		Revision as of 10:01, 17 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7bup ~~is ON HOLD until Apr 07 2022~~	+	==Crystal structure of PCNA from pathogenic yeast Candida albicans==
-		+	<StructureSection load='7bup' size='340' side='right'caption='[[7bup]]' scene=''>
-	~~Authors~~: ~~sundaram~~, R., ~~Vasudevan~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BUP FirstGlance]. <br>
-	~~Description: Crystal structure of PCNA from pathogenic yeast Candida albicans~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bup OCA], [https://pdbe.org/7bup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bup RCSB], [https://www.ebi.ac.uk/pdbsum/7bup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bup ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Sundaram, R~~]]	+	__TOC__
-	[[Category: ~~Vasudevan, D~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Vasudevan D]]
		+	[[Category: Sundaram R]]

OCA at 04:35, 22 April 2020

OCA — Wed, 22 Apr 2020 04:35:24 GMT

←Older revision		Revision as of 04:35, 22 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7bup is ON HOLD	+	The entry 7bup is ON HOLD until Apr 07 2022

	Authors: sundaram, R., Vasudevan, D.		Authors: sundaram, R., Vasudevan, D.
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	Description: Crystal structure of PCNA from pathogenic yeast Candida albicans		Description: Crystal structure of PCNA from pathogenic yeast Candida albicans
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Vasudevan, D]]
	[[Category: Sundaram, R]]		[[Category: Sundaram, R]]
		+	[[Category: Vasudevan, D]]

OCA: Protected "7bup" [edit=sysop:move=sysop]

OCA — Wed, 15 Apr 2020 05:42:53 GMT

Protected "7bup" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 15 April 2020

OCA: New page: '''Unreleased structure''' The entry 7bup is ON HOLD Authors: sundaram, R., Vasudevan, D. Description: Crystal structure of PCNA from pathogenic yeast Candida albicans [[Category: Unre...

OCA — Wed, 15 Apr 2020 05:42:52 GMT

New page: '''Unreleased structure''' The entry 7bup is ON HOLD Authors: sundaram, R., Vasudevan, D. Description: Crystal structure of PCNA from pathogenic yeast Candida albicans [[Category: Unre...

New page

'''Unreleased structure'''

The entry 7bup is ON HOLD

Authors: sundaram, R., Vasudevan, D.

Description: Crystal structure of PCNA from pathogenic yeast Candida albicans
[[Category: Unreleased Structures]]
[[Category: Vasudevan, D]]
[[Category: Sundaram, R]]