7bwk - Revision history

OCA at 15:37, 29 November 2023

OCA — Wed, 29 Nov 2023 15:37:52 GMT

←Older revision		Revision as of 15:37, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='7bwk' size='340' side='right'caption='[[7bwk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='7bwk' size='340' side='right'caption='[[7bwk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7bwk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Legph Legph~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BWK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bwk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BWK FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>icmO, lpg0446 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~272624 LEGPH])~~, ~~icmS, lpg0442 (~~[~~https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), icmW, lpg2688 (~~[~~https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH~~]~~), lpg0525 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH~~]~~), lpg1227 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=272624 LEGPH])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.801Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwk OCA], [https://pdbe.org/7bwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwk RCSB], [https://www.ebi.ac.uk/pdbsum/7bwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwk OCA], [https://pdbe.org/7bwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwk RCSB], [https://www.ebi.ac.uk/pdbsum/7bwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DOTL_LEGPH DOTL_LEGPH] Component of the Dot/Icm type IVB secretion system (T4BSS), which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:17040490, PubMed:22694730, PubMed:32513920). Part of a subcomplex which recruits effector proteins and delivers them to the core transmembrane subcomplex (PubMed:23028312, PubMed:32513920). Plays a central role in the assembly of the subcomplex (PubMed:32513920). Required for the recruitment of IcmS and IcmW to the inner membrane and for the translocation of adapter-dependent substrates (PubMed:23028312). May have ATPase activity (Probable).<ref>PMID:17040490</ref> <ref>PMID:22694730</ref> <ref>PMID:23028312</ref> <ref>PMID:32513920</ref> <ref>PMID:32513920</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Legph~~]]	+	[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
-	[[Category: Kim, H]]	+	[[Category: Kim H]]
-	[[Category: Kwak~~, M J~~]]	+	[[Category: Kwak MJ]]
-	[[Category: Oh~~, B H]]~~	+	[[Category: Oh BH]]
-	~~[[Category: Dot/icm type 4b secretion system]]~~	+
-	~~[[Category: Dotl-icmsw-lvga]]~~	+
-	~~[[Category: Effector recognition]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Type 4b coupling protein complex-effector complex]]~~	+
-	~~[[Category: Vpdb~~]]	+

OCA at 15:23, 8 June 2021

OCA — Tue, 08 Jun 2021 15:23:07 GMT

←Older revision		Revision as of 15:23, 8 June 2021
Line 3:		Line 3:
	<StructureSection load='7bwk' size='340' side='right'caption='[[7bwk]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='7bwk' size='340' side='right'caption='[[7bwk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7bwk]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7BWK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bwk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BWK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icmO, lpg0446 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), icmS, lpg0442 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), icmW, lpg2688 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), lpg0525 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), lpg1227 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icmO, lpg0446 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), icmS, lpg0442 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), icmW, lpg2688 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), lpg0525 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), lpg1227 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7bwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwk OCA], [~~http~~://pdbe.org/7bwk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7bwk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7bwk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwk OCA], [https://pdbe.org/7bwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwk RCSB], [https://www.ebi.ac.uk/pdbsum/7bwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:55, 10 June 2020

OCA — Wed, 10 Jun 2020 06:55:42 GMT

←Older revision		Revision as of 06:55, 10 June 2020
Line 1:		Line 1:

-	==~~n/a~~==	+	==Structure of DotL(656-783)-IcmS-IcmW-LvgA-VpdB(461-590) derived from Legionella pneumophila==
-	<StructureSection load='7bwk' size='340' side='right'caption='[[7bwk]]' scene=''>	+	<StructureSection load='7bwk' size='340' side='right'caption='[[7bwk]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BWK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bwk]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BWK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwk OCA], [http://pdbe.org/7bwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bwk RCSB], [http://www.ebi.ac.uk/pdbsum/7bwk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwk ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">icmO, lpg0446 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), icmS, lpg0442 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), icmW, lpg2688 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), lpg0525 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), lpg1227 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwk OCA], [http://pdbe.org/7bwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bwk RCSB], [http://www.ebi.ac.uk/pdbsum/7bwk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwk ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Legionella pneumophila Dot/Icm type IVB secretion system (T4BSS) is extremely versatile, translocating ~300 effector proteins into host cells. This specialized secretion system employs the Dot/Icm type IVB coupling protein (T4CP) complex, which includes IcmS, IcmW and LvgA, that are known to selectively assist the export of a subclass of effectors. Herein, the crystal structure of a four-subunit T4CP subcomplex bound to the effector protein VpdB reveals an interaction between LvgA and a linear motif in the C-terminus of VpdB. The same binding interface of LvgA also interacts with the C-terminal region of three additional effectors, SidH, SetA and PieA. Mutational analyses identified a FxxxLxxxK binding motif that is shared by VpdB and SidH, but not by SetA and PieA, showing that LvgA recognizes more than one type of binding motif. Together, this work provides a structural basis for how the Dot/Icm T4CP complex recognizes effectors, and highlights the multiple substrate-binding specificities of its adaptor subunit.
		+
		+	Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex.,Kim H, Kubori T, Yamazaki K, Kwak MJ, Park SY, Nagai H, Vogel JP, Oh BH Nat Commun. 2020 May 26;11(1):2623. doi: 10.1038/s41467-020-16397-0. PMID:32457311<ref>PMID:32457311</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7bwk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: N/a]]	+	[[Category: Legph]]
		+	[[Category: Kim, H]]
		+	[[Category: Kwak, M J]]
		+	[[Category: Oh, B H]]
		+	[[Category: Dot/icm type 4b secretion system]]
		+	[[Category: Dotl-icmsw-lvga]]
		+	[[Category: Effector recognition]]
		+	[[Category: Protein transport]]
		+	[[Category: Type 4b coupling protein complex-effector complex]]
		+	[[Category: Vpdb]]

OCA at 06:30, 3 June 2020

OCA — Wed, 03 Jun 2020 06:30:08 GMT

←Older revision		Revision as of 06:30, 3 June 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7bwk ~~is ON HOLD until Paper Publication~~	+	==n/a==
-		+	<StructureSection load='7bwk' size='340' side='right'caption='[[7bwk]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BWK FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwk OCA], [http://pdbe.org/7bwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bwk RCSB], [http://www.ebi.ac.uk/pdbsum/7bwk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwk ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: N/a]]

OCA at 05:35, 29 April 2020

OCA — Wed, 29 Apr 2020 05:35:01 GMT

←Older revision		Revision as of 05:35, 29 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7bwk is ON HOLD	+	The entry 7bwk is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7bwk" [edit=sysop:move=sysop]

OCA — Wed, 22 Apr 2020 04:39:00 GMT

Protected "7bwk" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:39, 22 April 2020

OCA: New page: '''Unreleased structure''' The entry 7bwk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Apr 2020 04:38:58 GMT

New page: '''Unreleased structure''' The entry 7bwk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7bwk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]