OCA at 15:38, 29 November 2023

OCA — Wed, 29 Nov 2023 15:38:07 GMT

←Older revision		Revision as of 15:38, 29 November 2023
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	==Structure of antibiotic sequester from Pseudomonas aerurinosa==		==Structure of antibiotic sequester from Pseudomonas aerurinosa==
-	<StructureSection load='7bwl' size='340' side='right'caption='[[7bwl]]' scene=''>	+	<StructureSection load='7bwl' size='340' side='right'caption='[[7bwl]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7BWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BWL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7bwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwl OCA], [~~http~~://pdbe.org/7bwl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7bwl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7bwl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UQ8:UBIQUINONE-8'>UQ8</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwl OCA], [https://pdbe.org/7bwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwl RCSB], [https://www.ebi.ac.uk/pdbsum/7bwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Y423_PSEAE Y423_PSEAE]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pseudomonas aeruginosa is a widely found opportunistic pathogen. The emergence of multidrug-resistant strains and persistent chronic infections have increased. The protein encoded by the pa0423 gene in P. aeruginosa is proposed to be critical for pathogenesis and could be a virulence-promoting protease or a bacterial lipocalin that binds a lipid-like antibiotic for drug resistance. Although two functions of proteolysis and antibiotic resistance are mutually related to bacterial survival in the host, it is very unusual for a single-domain protein to target unrelated ligand molecules such as protein substrates and lipid-like antibiotics. To clearly address the biological role of the PA0423 protein, we performed structural and biochemical studies. We found that PA0423 adopts a single-domain beta-barrel structure and belongs to the lipocalin family. The PA0423 structure houses an internal tubular cavity, which accommodates a ubiquinone-8 molecule. Furthermore, we reveal that PA0423 can directly interact with the polymyxin B antibiotic using the internal cavity, suggesting that PA0423 has a physiological function in the antibiotic resistance of P. aeruginosa.
		+
		+	Crystal structure of the Pseudomonas aeruginosa PA0423 protein and its functional implication in antibiotic sequestration.,Lee C, Kim MI, Park J, Kim J, Oh H, Cho Y, Son J, Jeon BY, Ka H, Hong M Biochem Biophys Res Commun. 2020 Jul 12;528(1):85-91. doi: , 10.1016/j.bbrc.2020.05.023. Epub 2020 May 22. PMID:32451086<ref>PMID:32451086</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7bwl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Pseudomonas aeruginosa PAO1]]
	[[Category: Hong M]]		[[Category: Hong M]]

OCA at 07:54, 2 December 2020

OCA — Wed, 02 Dec 2020 07:54:26 GMT

←Older revision		Revision as of 07:54, 2 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7bwl ~~is ON HOLD~~	+	==Structure of antibiotic sequester from Pseudomonas aerurinosa==
-		+	<StructureSection load='7bwl' size='340' side='right'caption='[[7bwl]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BWL FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwl OCA], [http://pdbe.org/7bwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bwl RCSB], [http://www.ebi.ac.uk/pdbsum/7bwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwl ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hong M]]

OCA: Protected "7bwl" [edit=sysop:move=sysop]

OCA — Wed, 22 Apr 2020 04:39:03 GMT

Protected "7bwl" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:39, 22 April 2020

OCA: New page: '''Unreleased structure''' The entry 7bwl is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Apr 2020 04:39:02 GMT

New page: '''Unreleased structure''' The entry 7bwl is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7bwl is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7bwl - Revision history

OCA at 15:38, 29 November 2023

OCA at 07:54, 2 December 2020

OCA: Protected "7bwl" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7bwl is ON HOLD Authors: Description: Category: Unreleased Structures