OCA at 15:38, 29 November 2023

OCA — Wed, 29 Nov 2023 15:38:28 GMT

←Older revision		Revision as of 15:38, 29 November 2023
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-	====	+	==SopD-Rab8 complex structure==
-	<StructureSection load='7bwt' size='340' side='right'caption='[[7bwt]]' scene=''>	+	<StructureSection load='7bwt' size='340' side='right'caption='[[7bwt]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bwt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BWT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwt OCA], [https://pdbe.org/7bwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwt RCSB], [https://www.ebi.ac.uk/pdbsum/7bwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwt ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwt OCA], [https://pdbe.org/7bwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwt RCSB], [https://www.ebi.ac.uk/pdbsum/7bwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwt ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SOPD_SALTY SOPD_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Contributes to replication in macrophages. Plays a role, cooperatively with SopB, in membrane fission and macropinosome formation during invasion.<ref>PMID:15554961</ref> <ref>PMID:17696999</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The food-borne bacterial pathogen Salmonella Typhimurium uses a type III protein secretion system to deliver multiple proteins into host cells. These secreted effectors modulate the functions of host cells and activate specific signalling cascades that result in the production of pro-inflammatory cytokines and intestinal inflammation. Some of the Salmonella-encoded effectors counteract this inflammatory response and help to preserve host homeostasis. Here, we demonstrate that the Salmonella effector protein SopD, which is required for pathogenesis, functions to both activate and inhibit the inflammatory response by targeting the Rab8 GTPase, which is a negative regulator of inflammation. We show that SopD has GTPase-activating protein activity for Rab8 and, therefore, inhibits this GTPase and stimulates inflammation. We also show that SopD activates Rab8 by displacing it from its cognate guanosine dissociation inhibitor, resulting in the stimulation of a signalling cascade that suppresses inflammation. We solved the crystal structure of SopD in association with Rab8 to a resolution of 2.3 A, which reveals a unique contact interface that underlies these complex interactions. These findings show the remarkable evolution of a bacterial effector protein to exert both agonistic and antagonistic activities towards the same host cellular target to modulate the inflammatory response.
		+
		+	The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response.,Lian H, Jiang K, Tong M, Chen Z, Liu X, Galan JE, Gao X Nat Microbiol. 2021 May;6(5):658-671. doi: 10.1038/s41564-021-00866-3. Epub 2021 , Feb 18. PMID:33603205<ref>PMID:33603205</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7bwt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ras-related protein Rab 3D structures\|Ras-related protein Rab 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z~~-disk~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
		+	[[Category: Chen Z]]
		+	[[Category: Gao X]]
		+	[[Category: Jiang K]]
		+	[[Category: Tong M]]

OCA at 06:39, 24 February 2021

OCA — Wed, 24 Feb 2021 06:39:56 GMT

←Older revision		Revision as of 06:39, 24 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7bwt ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7bwt' size='340' side='right'caption='[[7bwt]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwt OCA], [https://pdbe.org/7bwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwt RCSB], [https://www.ebi.ac.uk/pdbsum/7bwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwt ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:24, 3 June 2020

OCA — Wed, 03 Jun 2020 05:24:41 GMT

←Older revision		Revision as of 05:24, 3 June 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7bwt is ON HOLD	+	The entry 7bwt is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7bwt" [edit=sysop:move=sysop]

OCA — Wed, 22 Apr 2020 04:39:33 GMT

Protected "7bwt" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:39, 22 April 2020

OCA: New page: '''Unreleased structure''' The entry 7bwt is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Apr 2020 04:39:31 GMT

New page: '''Unreleased structure''' The entry 7bwt is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7bwt is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7bwt - Revision history

OCA at 15:38, 29 November 2023

OCA at 06:39, 24 February 2021

OCA at 05:24, 3 June 2020

OCA: Protected "7bwt" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7bwt is ON HOLD Authors: Description: Category: Unreleased Structures