7bxf - Revision history

OCA at 15:39, 29 November 2023

OCA — Wed, 29 Nov 2023 15:39:37 GMT

←Older revision		Revision as of 15:39, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='7bxf' size='340' side='right'caption='[[7bxf]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='7bxf' size='340' side='right'caption='[[7bxf]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7bxf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Legph Legph~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BXF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7BXF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bxf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BXF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~lpg2148 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=272624 LEGPH]), lpg2149 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7bxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bxf OCA], [~~http~~://pdbe.org/7bxf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7bxf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7bxf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7bxf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bxf OCA], [https://pdbe.org/7bxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bxf RCSB], [https://www.ebi.ac.uk/pdbsum/7bxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bxf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5ZTL3_LEGPH Q5ZTL3_LEGPH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Legph~~]]	+	[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
-	[[Category: Gao, P]]	+	[[Category: Gao P]]
-	~~[[Category: Deubiquitination]]~~	+
-	~~[[Category: Lpg2149]]~~	+
-	~~[[Category: Mavc]]~~	+
-	~~[[Category: Mvca]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Ube2n]]~~	+
-	~~[[Category: Ubiquitination~~]]	+

OCA at 10:05, 9 September 2020

OCA — Wed, 09 Sep 2020 10:05:32 GMT

←Older revision		Revision as of 10:05, 9 September 2020
Line 1:		Line 1:

	==MvcA-Lpg2149 complex==		==MvcA-Lpg2149 complex==
-	<StructureSection load='7bxf' size='340' side='right'caption='[[7bxf]]' scene=''>	+	<StructureSection load='7bxf' size='340' side='right'caption='[[7bxf]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BXF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BXF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bxf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BXF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BXF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bxf OCA], [http://pdbe.org/7bxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bxf RCSB], [http://www.ebi.ac.uk/pdbsum/7bxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bxf ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpg2148 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH]), lpg2149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bxf OCA], [http://pdbe.org/7bxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bxf RCSB], [http://www.ebi.ac.uk/pdbsum/7bxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bxf ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N's function in forming K63-linked ubiquitin (Ub) chains and dampening NF-small ka, CyrillicB signaling. We now report the structures of MavC in complex with conjugated UBE2N~Ub and an inhibitor protein Lpg2149, as well as the structure of its ortholog, MvcA, bound to Lpg2149. Recognition of UBE2N and Ub depends on several unique features of MavC, which explains the inability of MvcA to catalyze ubiquitination. Unexpectedly, MavC and MvcA also possess deubiquitinase activity against MavC-mediated ubiquitination, highlighting MavC as a unique enzyme possessing deamidation, ubiquitination, and deubiquitination activities. Further, Lpg2149 directly binds and inhibits both MavC and MvcA by disrupting the interactions between enzymes and Ub. These results provide detailed insights into catalysis and regulation of MavC-type enzymes and the molecular mechanisms of this non-canonical ubiquitination machinery.
		+
		+	Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors.,Wang Y, Zhan Q, Wang X, Li P, Liu S, Gao G, Gao P Nat Commun. 2020 Jun 2;11(1):2751. doi: 10.1038/s41467-020-16587-w. PMID:32488130<ref>PMID:32488130</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7bxf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao P]]	+	[[Category: Legph]]
		+	[[Category: Gao, P]]
		+	[[Category: Deubiquitination]]
		+	[[Category: Lpg2149]]
		+	[[Category: Mavc]]
		+	[[Category: Mvca]]
		+	[[Category: Transferase]]
		+	[[Category: Ube2n]]
		+	[[Category: Ubiquitination]]

OCA at 05:53, 20 May 2020

OCA — Wed, 20 May 2020 05:53:48 GMT

←Older revision		Revision as of 05:53, 20 May 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7bxf ~~is ON HOLD until Paper Publication~~	+	==MvcA-Lpg2149 complex==
-		+	<StructureSection load='7bxf' size='340' side='right'caption='[[7bxf]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BXF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BXF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bxf OCA], [http://pdbe.org/7bxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bxf RCSB], [http://www.ebi.ac.uk/pdbsum/7bxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bxf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gao P]]

OCA at 04:52, 6 May 2020

OCA — Wed, 06 May 2020 04:52:25 GMT

←Older revision		Revision as of 04:52, 6 May 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7bxf is ON HOLD	+	The entry 7bxf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7bxf" [edit=sysop:move=sysop]

OCA — Wed, 29 Apr 2020 05:36:02 GMT

Protected "7bxf" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:36, 29 April 2020

OCA: New page: '''Unreleased structure''' The entry 7bxf is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Apr 2020 05:36:00 GMT

New page: '''Unreleased structure''' The entry 7bxf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7bxf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]