7bz6 - Revision history

OCA at 15:44, 29 November 2023

OCA — Wed, 29 Nov 2023 15:44:14 GMT

←Older revision		Revision as of 15:44, 29 November 2023
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	==Mycobacterium bovis AhpC==		==Mycobacterium bovis AhpC==
-	<StructureSection load='7bz6' size='340' side='right'caption='[[7bz6]]' scene=''>	+	<StructureSection load='7bz6' size='340' side='right'caption='[[7bz6]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7bz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_variant_bovis Mycobacterium tuberculosis variant bovis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BZ6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bz6 OCA], [https://pdbe.org/7bz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bz6 RCSB], [https://www.ebi.ac.uk/pdbsum/7bz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bz6 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.302Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bz6 OCA], [https://pdbe.org/7bz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bz6 RCSB], [https://www.ebi.ac.uk/pdbsum/7bz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bz6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q79CV0_MYCBI Q79CV0_MYCBI]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ability of Mycobacteria to overcome oxidative stress is of paramount importance for its survival within the host. One of the key enzymes that are involved in protecting the bacterium from reactive oxygen species is the catalase-peroxidase (KatG). However, in strains resistant to the antibiotic isoniazid, KatG is rendered ineffective, which is associated with an increased expression of alkylhydroperoxide reductase subunit C (AhpC). Mycobacterial AhpC possesses a unique helical displacement when compared to its bacterial counterparts. Here, via mutagenesis studies, we demonstrate the importance of this helix for redox modulation of the catalytic activity of AhpC. Along with structural insights from crystallographic data, the impact of critical residues on the structure and flexibility of the helix and on AhpC oligomerization is described.
		+
		+	Residues of helix a2 are critical for catalytic efficiency of mycobacterial alkylhydroperoxide reductase subunit C.,Chong SMS, Kamariah N, Gruber G FEBS Lett. 2020 Sep;594(17):2829-2839. doi: 10.1002/1873-3468.13864. Epub 2020, Jul 20. PMID:32557576<ref>PMID:32557576</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7bz6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mycobacterium tuberculosis variant bovis]]
	[[Category: Chong SMS]]		[[Category: Chong SMS]]
	[[Category: Gruber G]]		[[Category: Gruber G]]
	[[Category: Neelagandan K]]		[[Category: Neelagandan K]]

OCA at 17:16, 10 March 2021

OCA — Wed, 10 Mar 2021 17:16:56 GMT

←Older revision		Revision as of 17:16, 10 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7bz6 ~~is ON HOLD until Paper Publication~~	+	==Mycobacterium bovis AhpC==
-		+	<StructureSection load='7bz6' size='340' side='right'caption='[[7bz6]]' scene=''>
-	~~Authors~~: ~~Chong~~, S.M.S., ~~Neelagandan~~, K., ~~Gruber~~, G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BZ6 FirstGlance]. <br>
-	~~Description: Mycobacterium bovis AhpC~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bz6 OCA], [https://pdbe.org/7bz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bz6 RCSB], [https://www.ebi.ac.uk/pdbsum/7bz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bz6 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Gruber, G~~]]	+	__TOC__
-	[[Category: ~~Chong, S.M.S~~]]	+	</StructureSection>
-	[[Category: Neelagandan, K]]	+	[[Category: Large Structures]]
		+	[[Category: Chong SMS]]
		+	[[Category: Gruber G]]
		+	[[Category: Neelagandan K]]

OCA at 04:22, 13 May 2020

OCA — Wed, 13 May 2020 04:22:12 GMT

←Older revision		Revision as of 04:22, 13 May 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7bz6 is ON HOLD	+	The entry 7bz6 is ON HOLD until Paper Publication

	Authors: Chong, S.M.S., Neelagandan, K., Gruber, G.		Authors: Chong, S.M.S., Neelagandan, K., Gruber, G.

OCA: Protected "7bz6" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2020 04:54:25 GMT

Protected "7bz6" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:54, 6 May 2020

OCA: New page: '''Unreleased structure''' The entry 7bz6 is ON HOLD Authors: Chong, S.M.S., Neelagandan, K., Gruber, G. Description: Mycobacterium bovis AhpC Category: Unreleased Structures [[Cat...

OCA — Wed, 06 May 2020 04:54:24 GMT

New page: '''Unreleased structure''' The entry 7bz6 is ON HOLD Authors: Chong, S.M.S., Neelagandan, K., Gruber, G. Description: Mycobacterium bovis AhpC Category: Unreleased Structures [[Cat...

New page

'''Unreleased structure'''

The entry 7bz6 is ON HOLD

Authors: Chong, S.M.S., Neelagandan, K., Gruber, G.

Description: Mycobacterium bovis AhpC
[[Category: Unreleased Structures]]
[[Category: Gruber, G]]
[[Category: Chong, S.M.S]]
[[Category: Neelagandan, K]]