7c62 - Revision history

OCA at 15:57, 29 November 2023

OCA — Wed, 29 Nov 2023 15:57:29 GMT

←Older revision		Revision as of 15:57, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='7c62' size='340' side='right'caption='[[7c62]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='7c62' size='340' side='right'caption='[[7c62]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7c62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C62 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7c62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C62 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.027Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PARK7 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c62 OCA], [https://pdbe.org/7c62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c62 RCSB], [https://www.ebi.ac.uk/pdbsum/7c62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c62 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c62 OCA], [https://pdbe.org/7c62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c62 RCSB], [https://www.ebi.ac.uk/pdbsum/7c62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c62 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PARK7_HUMAN PARK7_HUMAN]] Defects in PARK7 are the cause of Parkinson disease type 7 (PARK7) [MIM:[https://omim.org/entry/606324 606324]]. A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease).<ref>PMID:12851414</ref> <ref>PMID:12446870</ref> <ref>PMID:14713311</ref> <ref>PMID:12953260</ref> <ref>PMID:15365989</ref> <ref>PMID:14607841</ref> <ref>PMID:15254937</ref> <ref>PMID:17846173</ref>	+	[https://www.uniprot.org/uniprot/PARK7_HUMAN PARK7_HUMAN] Defects in PARK7 are the cause of Parkinson disease type 7 (PARK7) [MIM:[https://omim.org/entry/606324 606324]. A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease).<ref>PMID:12851414</ref> <ref>PMID:12446870</ref> <ref>PMID:14713311</ref> <ref>PMID:12953260</ref> <ref>PMID:15365989</ref> <ref>PMID:14607841</ref> <ref>PMID:15254937</ref> <ref>PMID:17846173</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PARK7_HUMAN PARK7_HUMAN]] Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone.<ref>PMID:9070310</ref> <ref>PMID:11477070</ref> <ref>PMID:12612053</ref> <ref>PMID:14749723</ref> <ref>PMID:15502874</ref> <ref>PMID:15976810</ref> <ref>PMID:16390825</ref> <ref>PMID:17015834</ref> <ref>PMID:18626009</ref> <ref>PMID:18711745</ref> <ref>PMID:20304780</ref> <ref>PMID:21097510</ref> <ref>PMID:12939276</ref> <ref>PMID:15181200</ref>	+	[https://www.uniprot.org/uniprot/PARK7_HUMAN PARK7_HUMAN] Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone.<ref>PMID:9070310</ref> <ref>PMID:11477070</ref> <ref>PMID:12612053</ref> <ref>PMID:14749723</ref> <ref>PMID:15502874</ref> <ref>PMID:15976810</ref> <ref>PMID:16390825</ref> <ref>PMID:17015834</ref> <ref>PMID:18626009</ref> <ref>PMID:18711745</ref> <ref>PMID:20304780</ref> <ref>PMID:21097510</ref> <ref>PMID:12939276</ref> <ref>PMID:15181200</ref>

	==See Also==		==See Also==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lin, D]]	+	[[Category: Lin D]]
-	[[Category: Lv, Z]]	+	[[Category: Lv Z]]
-	[[Category: Tan, J]]	+	[[Category: Tan J]]
-	[[Category: Wang, F]]	+	[[Category: Wang F]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Oxidative stress sensor]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Redox-sensitive chaperone~~]]	+

OCA at 07:31, 9 February 2022

OCA — Wed, 09 Feb 2022 07:31:20 GMT

←Older revision		Revision as of 07:31, 9 February 2022
Line 1:		Line 1:

-	==The Crystal Structure of Parkinson disease protein 7 (DJ-1) from ~~Wuxi~~ Biortus.==	+	==The Crystal Structure of Parkinson disease protein 7 (DJ-1) from Biortus==
-	<StructureSection load='7c62' size='340' side='right'caption='[[7c62]]' scene=''>	+	<StructureSection load='7c62' size='340' side='right'caption='[[7c62]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C62 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7C62 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7c62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C62 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7c62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c62 OCA], [~~http~~://pdbe.org/7c62 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7c62 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7c62 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7c62 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PARK7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c62 OCA], [https://pdbe.org/7c62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c62 RCSB], [https://www.ebi.ac.uk/pdbsum/7c62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c62 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/PARK7_HUMAN PARK7_HUMAN]] Defects in PARK7 are the cause of Parkinson disease type 7 (PARK7) [MIM:[https://omim.org/entry/606324 606324]]. A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease).<ref>PMID:12851414</ref> <ref>PMID:12446870</ref> <ref>PMID:14713311</ref> <ref>PMID:12953260</ref> <ref>PMID:15365989</ref> <ref>PMID:14607841</ref> <ref>PMID:15254937</ref> <ref>PMID:17846173</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/PARK7_HUMAN PARK7_HUMAN]] Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone.<ref>PMID:9070310</ref> <ref>PMID:11477070</ref> <ref>PMID:12612053</ref> <ref>PMID:14749723</ref> <ref>PMID:15502874</ref> <ref>PMID:15976810</ref> <ref>PMID:16390825</ref> <ref>PMID:17015834</ref> <ref>PMID:18626009</ref> <ref>PMID:18711745</ref> <ref>PMID:20304780</ref> <ref>PMID:21097510</ref> <ref>PMID:12939276</ref> <ref>PMID:15181200</ref>
		+
		+	==See Also==
		+	*[[Protein DJ-1\|Protein DJ-1]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lin D]]	+	[[Category: Lin, D]]
-	[[Category: Lv Z]]	+	[[Category: Lv, Z]]
-	[[Category: Tan J]]	+	[[Category: Tan, J]]
-	[[Category: Wang F]]	+	[[Category: Wang, F]]
		+	[[Category: Chaperone]]
		+	[[Category: Oxidative stress sensor]]
		+	[[Category: Protease]]
		+	[[Category: Redox-sensitive chaperone]]

OCA at 14:13, 8 July 2020

OCA — Wed, 08 Jul 2020 14:13:20 GMT

←Older revision		Revision as of 14:13, 8 July 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7c62 is ON HOLD~~	+	==The Crystal Structure of Parkinson disease protein 7 (DJ-1) from Wuxi Biortus.==
-		+	<StructureSection load='7c62' size='340' side='right'caption='[[7c62]]' scene=''>
-	~~Authors: Wang, F., Lin, D., Lv, Z., Tan, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C62 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7C62 FirstGlance]. <br>
-	~~Description:~~ The Crystal Structure of Parkinson disease protein 7 (DJ-1) from Wuxi Biortus.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7c62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c62 OCA], [http://pdbe.org/7c62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7c62 RCSB], [http://www.ebi.ac.uk/pdbsum/7c62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7c62 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Tan~~, J]]	+	__TOC__
-	[[Category: ~~Lin, D~~]]	+	</StructureSection>
-	[[Category: ~~Wang, F~~]]	+	[[Category: Large Structures]]
-	[[Category: Lv, Z]]	+	[[Category: Lin D]]
		+	[[Category: Lv Z]]
		+	[[Category: Tan J]]
		+	[[Category: Wang F]]

OCA: Protected "7c62" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2020 05:18:42 GMT

Protected "7c62" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 27 May 2020

OCA: New page: '''Unreleased structure''' The entry 7c62 is ON HOLD Authors: Wang, F., Lin, D., Lv, Z., Tan, J. Description: The Crystal Structure of Parkinson disease protein 7 (DJ-1) from Wuxi Bior...

OCA — Wed, 27 May 2020 05:18:40 GMT

New page: '''Unreleased structure''' The entry 7c62 is ON HOLD Authors: Wang, F., Lin, D., Lv, Z., Tan, J. Description: The Crystal Structure of Parkinson disease protein 7 (DJ-1) from Wuxi Bior...

New page

'''Unreleased structure'''

The entry 7c62 is ON HOLD

Authors: Wang, F., Lin, D., Lv, Z., Tan, J.

Description: The Crystal Structure of Parkinson disease protein 7 (DJ-1) from Wuxi Biortus.
[[Category: Unreleased Structures]]
[[Category: Tan, J]]
[[Category: Lin, D]]
[[Category: Wang, F]]
[[Category: Lv, Z]]