7cdw - Revision history

OCA at 10:48, 16 February 2022

OCA — Wed, 16 Feb 2022 10:48:57 GMT

←Older revision		Revision as of 10:48, 16 February 2022
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	==Crystal Structure of Mycobacterium Tuberculosis Elongation Factor G1==		==Crystal Structure of Mycobacterium Tuberculosis Elongation Factor G1==
-	<StructureSection load='7cdw' size='340' side='right'caption='[[7cdw]]' scene=''>	+	<StructureSection load='7cdw' size='340' side='right'caption='[[7cdw]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CDW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7cdw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CDW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cdw OCA], [https://pdbe.org/7cdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cdw RCSB], [https://www.ebi.ac.uk/pdbsum/7cdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cdw ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cdw OCA], [https://pdbe.org/7cdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cdw RCSB], [https://www.ebi.ac.uk/pdbsum/7cdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cdw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/EFG_MYCTU EFG_MYCTU]] Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis (Mtb) caused an estimated 10 million cases of tuberculosis and 1.2 million deaths in 2019 globally. The increasing emergence of multidrug-resistant and extensively drug-resistant Mtb is becoming a public health threat worldwide and makes the identification of anti-Mtb drug targets urgent. Elongation factor G (EF-G) is involved in tRNA translocation on ribosomes during protein translation. Therefore, EF-G is a major focus of structural analysis and a valuable drug target of antibiotics. However, the crystal structure of Mtb EF-G1 is not yet available, and this has limited the design of inhibitors. Here, we report the crystal structure of Mtb EF-G1 in complex with GDP. The unique crystal form of the Mtb EF-G1-GDP complex provides an excellent platform for fragment-based screening using a crystallographic approach. Our findings provide a structure-based explanation for GDP recognition, and facilitate the identification of EF-G1 inhibitors with potential interest in the context of drug discovery.
		+
		+	Crystal Structure of Mycobacterium tuberculosis Elongation Factor G1.,Gao X, Yu X, Zhu K, Qin B, Wang W, Han P, Aleksandra Wojdyla J, Wang M, Cui S Front Mol Biosci. 2021 Sep 3;8:667638. doi: 10.3389/fmolb.2021.667638., eCollection 2021. PMID:34540889<ref>PMID:34540889</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7cdw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cui S]]	+	[[Category: Cui, S]]
-	[[Category: Gao X]]	+	[[Category: Gao, X]]
		+	[[Category: Antituberculosis drug]]
		+	[[Category: Crystal structure]]
		+	[[Category: Gtpase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Ribosome-bound ef-g]]

OCA at 06:48, 22 September 2021

OCA — Wed, 22 Sep 2021 06:48:53 GMT

←Older revision		Revision as of 06:48, 22 September 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7cdw ~~is ON HOLD~~	+	==Crystal Structure of Mycobacterium Tuberculosis Elongation Factor G1==
-		+	<StructureSection load='7cdw' size='340' side='right'caption='[[7cdw]]' scene=''>
-	~~Authors~~: ~~Gao~~, X., ~~Cui~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CDW FirstGlance]. <br>
-	~~Description: Crystal Structure of Mycobacterium Tuberculosis Elongation Factor G1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cdw OCA], [https://pdbe.org/7cdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cdw RCSB], [https://www.ebi.ac.uk/pdbsum/7cdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cdw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Gao, X~~]]	+	__TOC__
-	[[Category: ~~Cui, S~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cui S]]
		+	[[Category: Gao X]]

OCA at 04:08, 28 April 2021

OCA — Wed, 28 Apr 2021 04:08:45 GMT

←Older revision		Revision as of 04:08, 28 April 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7cdw is ON HOLD ~~until Paper Publication~~	+	The entry 7cdw is ON HOLD

	Authors: Gao, X., Cui, S.		Authors: Gao, X., Cui, S.

OCA: Protected "7cdw" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 11:26:22 GMT

Protected "7cdw" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:26, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 7cdw is ON HOLD until Paper Publication Authors: Gao, X., Cui, S. Description: Crystal Structure of Mycobacterium Tuberculosis Elongation Factor G1...

OCA — Wed, 08 Jul 2020 11:26:20 GMT

New page: '''Unreleased structure''' The entry 7cdw is ON HOLD until Paper Publication Authors: Gao, X., Cui, S. Description: Crystal Structure of Mycobacterium Tuberculosis Elongation Factor G1...

New page

'''Unreleased structure'''

The entry 7cdw is ON HOLD until Paper Publication

Authors: Gao, X., Cui, S.

Description: Crystal Structure of Mycobacterium Tuberculosis Elongation Factor G1
[[Category: Unreleased Structures]]
[[Category: Gao, X]]
[[Category: Cui, S]]