7ce0 - Revision history

OCA at 16:06, 29 November 2023

OCA — Wed, 29 Nov 2023 16:06:35 GMT

←Older revision		Revision as of 16:06, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='7ce0' size='340' side='right'caption='[[7ce0]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='7ce0' size='340' side='right'caption='[[7ce0]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7ce0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~2019-ncov 2019-ncov~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CE0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ce0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CE0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ce0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce0 OCA], [https://pdbe.org/7ce0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ce0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ce0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce0 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ce0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce0 OCA], [https://pdbe.org/7ce0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ce0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ce0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NCAP_SARS2 NCAP_SARS2]] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.	+	[https://www.uniprot.org/uniprot/NCAP_SARS2 NCAP_SARS2] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 2019-ncov]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao~~, G F~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
-	[[Category: Peng, Y]]	+	[[Category: Gao GF]]
-	[[Category: Qi, J]]	+	[[Category: Peng Y]]
-	[[Category: Song, H]]	+	[[Category: Qi J]]
-	~~[[Category: Covid-19]]~~	+	[[Category: Song H]]
-	~~[[Category: Dimerization]]~~	+
-	~~[[Category: Nucleocapsid]]~~	+
-	~~[[Category: Rna binding]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 18:02, 10 March 2021

OCA — Wed, 10 Mar 2021 18:02:02 GMT

←Older revision		Revision as of 18:02, 10 March 2021
Line 3:		Line 3:
	<StructureSection load='7ce0' size='340' side='right'caption='[[7ce0]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='7ce0' size='340' side='right'caption='[[7ce0]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7ce0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CE0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7CE0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ce0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CE0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7ce0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce0 OCA], [~~http~~://pdbe.org/7ce0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7ce0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7ce0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce0 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ce0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce0 OCA], [https://pdbe.org/7ce0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ce0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ce0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NCAP_SARS2 NCAP_SARS2]] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.	+	[[https://www.uniprot.org/uniprot/NCAP_SARS2 NCAP_SARS2]] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	COVID-19, caused by SARS-CoV-2, has resulted in severe and unprecedented economic and social disruptions in the world. Nucleocapsid (N) protein, which is the major structural component of the virion and is involved in viral replication, assembly and immune regulation, plays key roles in the viral life cycle. Here, we solved the crystal structures of the N- and C-terminal domains (N-NTD and N-CTD) of SARS-CoV-2 N protein, at 1.8 and 1.5 A resolution, respectively. Both structures show conserved features from other CoV N proteins. The binding sites targeted by small molecules against HCoV-OC43 and MERS-CoV, which inhibit viral infection by blocking the RNA-binding activity or normal oligomerization of N protein, are relatively conserved in our structure, indicating N protein is a promising drug target. In addition, certain areas of N-NTD and N-CTD display distinct charge distribution patterns in SARS-CoV-2, which may alter the RNA-binding modes. The specific antigenic characteristics are critical for developing specific immune-based rapid diagnostic tests. Our structural information can aid in the discovery and development of antiviral inhibitors against SARS-CoV-2 in the future.
		+
		+	Structures of the SARS-CoV-2 nucleocapsid and their perspectives for drug design.,Peng Y, Du N, Lei Y, Dorje S, Qi J, Luo T, Gao GF, Song H EMBO J. 2020 Oct 15;39(20):e105938. doi: 10.15252/embj.2020105938. Epub 2020 Sep , 11. PMID:32914439<ref>PMID:32914439</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ce0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]		*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:20, 2 December 2020

OCA — Wed, 02 Dec 2020 08:20:57 GMT

←Older revision		Revision as of 08:20, 2 December 2020
Line 1:		Line 1:

	==Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) protein==		==Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) protein==
-	<StructureSection load='7ce0' size='340' side='right'caption='[[7ce0]]' scene=''>	+	<StructureSection load='7ce0' size='340' side='right'caption='[[7ce0]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CE0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CE0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ce0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CE0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CE0 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ce0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce0 OCA], [http://pdbe.org/7ce0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ce0 RCSB], [http://www.ebi.ac.uk/pdbsum/7ce0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce0 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ce0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce0 OCA], [http://pdbe.org/7ce0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ce0 RCSB], [http://www.ebi.ac.uk/pdbsum/7ce0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NCAP_SARS2 NCAP_SARS2]] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
		+
		+	==See Also==
		+	*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: 2019-ncov]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao GF]]	+	[[Category: Gao, G F]]
-	[[Category: Peng Y]]	+	[[Category: Peng, Y]]
-	[[Category: Qi J]]	+	[[Category: Qi, J]]
-	[[Category: Song H]]	+	[[Category: Song, H]]
		+	[[Category: Covid-19]]
		+	[[Category: Dimerization]]
		+	[[Category: Nucleocapsid]]
		+	[[Category: Rna binding]]
		+	[[Category: Viral protein]]

OCA at 06:54, 2 September 2020

OCA — Wed, 02 Sep 2020 06:54:46 GMT

←Older revision		Revision as of 06:54, 2 September 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7ce0 ~~is ON HOLD~~	+	==Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) protein==
-		+	<StructureSection load='7ce0' size='340' side='right'caption='[[7ce0]]' scene=''>
-	~~Authors~~: ~~Peng~~, Y., ~~Qi, J~~., ~~Song, H~~., ~~Gao~~, G.F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CE0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7CE0 FirstGlance]. <br>
-	~~Description: Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) protein~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ce0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce0 OCA], [http://pdbe.org/7ce0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ce0 RCSB], [http://www.ebi.ac.uk/pdbsum/7ce0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce0 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Gao~~, G.F~~]]	+	__TOC__
-	[[Category: Peng, Y]]	+	</StructureSection>
-	[[Category: ~~Song, H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Qi, J~~]]	+	[[Category: Gao GF]]
		+	[[Category: Peng Y]]
		+	[[Category: Qi J]]
		+	[[Category: Song H]]

OCA: Protected "7ce0" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 11:26:41 GMT

Protected "7ce0" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:26, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 7ce0 is ON HOLD Authors: Peng, Y., Qi, J., Song, H., Gao, G.F. Description: Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) pro...

OCA — Wed, 08 Jul 2020 11:26:40 GMT

New page: '''Unreleased structure''' The entry 7ce0 is ON HOLD Authors: Peng, Y., Qi, J., Song, H., Gao, G.F. Description: Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) pro...

New page

'''Unreleased structure'''

The entry 7ce0 is ON HOLD

Authors: Peng, Y., Qi, J., Song, H., Gao, G.F.

Description: Crystal structure of 2019-nCoV nucleocapsid C-terminal domain (CTD) protein
[[Category: Unreleased Structures]]
[[Category: Gao, G.F]]
[[Category: Peng, Y]]
[[Category: Song, H]]
[[Category: Qi, J]]