OCA at 16:06, 29 November 2023

OCA — Wed, 29 Nov 2023 16:06:37 GMT

←Older revision		Revision as of 16:06, 29 November 2023
Line 1:		Line 1:

-	====	+	==The Crystal structure of TeNT Hc complexed with neutralizing antibody==
-	<StructureSection load='7ce2' size='340' side='right'caption='[[7ce2]]' scene=''>	+	<StructureSection load='7ce2' size='340' side='right'caption='[[7ce2]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ce2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CE2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ce2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce2 OCA], [https://pdbe.org/7ce2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ce2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ce2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce2 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ce2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce2 OCA], [https://pdbe.org/7ce2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ce2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ce2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9LA13_CLOTA Q9LA13_CLOTA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-TeNT immunoglobulin. TT0170 binds fragment B, and TT0069 and TT0155 bind fragment AB. mAb TT0067 binds fragment C and blocks the binding of TeNT to gangliosides. The co-crystal structure of TT0067 with fragment C of TeNT at a 2.0-A resolution demonstrates that mAb TT0067 directly occupies the W pocket of one of the receptor binding sites on TeNT, resulting in blocking the binding of TeNT to ganglioside on the surface of host cells. This study reveals at the atomic level the mechanism of action by the TeNT neutralizing antibody. The key neutralization epitope on the fragment C of TeNT identified in our work provides the critical information for the development of fragment C of TeNT as a better and safer tetanus vaccine.
		+
		+	Structural basis of tetanus toxin neutralization by native human monoclonal antibodies.,Wang Y, Wu C, Yu J, Lin S, Liu T, Zan L, Li N, Hong P, Wang X, Jia Z, Li J, Wang Y, Zhang M, Yuan X, Li C, Xu W, Zheng W, Wang X, Liao HX Cell Rep. 2021 May 4;35(5):109070. doi: 10.1016/j.celrep.2021.109070. PMID:33951441<ref>PMID:33951441</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ce2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	*[[Tetanus toxin\|Tetanus toxin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Clostridium tetani]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Liao H]]
		+	[[Category: Wang X]]
		+	[[Category: Wang Y]]
		+	[[Category: Wu C]]
		+	[[Category: Yu J]]

OCA at 06:49, 7 April 2021

OCA — Wed, 07 Apr 2021 06:49:57 GMT

←Older revision		Revision as of 06:49, 7 April 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ce2 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7ce2' size='340' side='right'caption='[[7ce2]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ce2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ce2 OCA], [https://pdbe.org/7ce2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ce2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ce2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ce2 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:07, 5 August 2020

OCA — Wed, 05 Aug 2020 04:07:21 GMT

←Older revision		Revision as of 04:07, 5 August 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ce2 is ON HOLD	+	The entry 7ce2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ce2" [edit=sysop:move=sysop]

OCA — Wed, 08 Jul 2020 11:26:48 GMT

Protected "7ce2" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:26, 8 July 2020

OCA: New page: '''Unreleased structure''' The entry 7ce2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jul 2020 11:26:46 GMT

New page: '''Unreleased structure''' The entry 7ce2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ce2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7ce2 - Revision history

OCA at 16:06, 29 November 2023

OCA at 06:49, 7 April 2021

OCA at 04:07, 5 August 2020

OCA: Protected "7ce2" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ce2 is ON HOLD Authors: Description: Category: Unreleased Structures