OCA at 16:10, 29 November 2023

OCA — Wed, 29 Nov 2023 16:10:48 GMT

←Older revision		Revision as of 16:10, 29 November 2023
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	==Crystal Structure of PAK4 in complex with inhibitor 41==		==Crystal Structure of PAK4 in complex with inhibitor 41==
-	<StructureSection load='7cmb' size='340' side='right'caption='[[7cmb]]' scene=''>	+	<StructureSection load='7cmb' size='340' side='right'caption='[[7cmb]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7cmb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CMB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmb OCA], [https://pdbe.org/7cmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cmb RCSB], [https://www.ebi.ac.uk/pdbsum/7cmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.592Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G5X:1-(2-azanylpyrimidin-4-yl)-6-[2-(1-oxidanylcyclohexyl)ethynyl]indole-3-carboxamide'>G5X</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmb OCA], [https://pdbe.org/7cmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cmb RCSB], [https://www.ebi.ac.uk/pdbsum/7cmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PAK4_HUMAN PAK4_HUMAN] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.<ref>PMID:11278822</ref> <ref>PMID:11313478</ref> <ref>PMID:14560027</ref> <ref>PMID:15660133</ref> <ref>PMID:20507994</ref> <ref>PMID:20805321</ref> <ref>PMID:20631255</ref>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li H]]		[[Category: Li H]]
	[[Category: Zhao F]]		[[Category: Zhao F]]

OCA at 10:32, 28 July 2021

OCA — Wed, 28 Jul 2021 10:32:10 GMT

←Older revision		Revision as of 10:32, 28 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7cmb ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of PAK4 in complex with inhibitor 41==
-		+	<StructureSection load='7cmb' size='340' side='right'caption='[[7cmb]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CMB FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cmb OCA], [https://pdbe.org/7cmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cmb RCSB], [https://www.ebi.ac.uk/pdbsum/7cmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cmb ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Li H]]
		+	[[Category: Zhao F]]

OCA at 05:33, 14 April 2021

OCA — Wed, 14 Apr 2021 05:33:16 GMT

←Older revision		Revision as of 05:33, 14 April 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7cmb is ON HOLD	+	The entry 7cmb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7cmb" [edit=sysop:move=sysop]

OCA — Wed, 05 Aug 2020 04:10:04 GMT

Protected "7cmb" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:10, 5 August 2020

OCA: New page: '''Unreleased structure''' The entry 7cmb is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Aug 2020 04:10:03 GMT

New page: '''Unreleased structure''' The entry 7cmb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7cmb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7cmb - Revision history

OCA at 16:10, 29 November 2023

OCA at 10:32, 28 July 2021

OCA at 05:33, 14 April 2021

OCA: Protected "7cmb" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7cmb is ON HOLD Authors: Description: Category: Unreleased Structures