7cpo - Revision history

OCA at 16:13, 29 November 2023

OCA — Wed, 29 Nov 2023 16:13:30 GMT

←Older revision		Revision as of 16:13, 29 November 2023
Line 1:		Line 1:

-	====	+	==Crystal Structure of Anolis carolinensis MHC I complex==
-	<StructureSection load='7cpo' size='340' side='right'caption='[[7cpo]]' scene=''>	+	<StructureSection load='7cpo' size='340' side='right'caption='[[7cpo]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7cpo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Anolis_carolinensis Anolis carolinensis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CPO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cpo OCA], [https://pdbe.org/7cpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cpo RCSB], [https://www.ebi.ac.uk/pdbsum/7cpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cpo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cpo OCA], [https://pdbe.org/7cpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cpo RCSB], [https://www.ebi.ac.uk/pdbsum/7cpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cpo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G1KTN1_ANOCA G1KTN1_ANOCA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The reptile MHC class I (MCH-I) and MHC class II proteins are the key molecules in the immune system; however, their structure has not been investigated. The crystal structure of green anole lizard peptide-MHC-I-beta2m (pMHC-I or pAnca-UA0101) was determined in the current study. Subsequently, the features of pAnca-UA0101 were analyzed and compared with the characteristics of pMHC-I of four classes of vertebrates. The amino acid sequence identities between Anca-UA0101 and MHC-I from other species are <50%; however, the differences between the species were reflected in the topological structure. Significant characteristics of pAnca-UA0101 include a specific flip of approximately 88 degrees and an upward shift adjacent to the C terminus of the alpha1- and alpha2-helical regions, respectively. Additionally, the lizard MHC-I molecule has an insertion of 2 aa (VE) at positions 55 and 56. The pushing force from 55-56VE triggers the flip of the alpha1 helix. Mutagenesis experiments confirmed that the 55-56VE insertion in the alpha1 helix enhances the stability of pAnca-UA0101. The peptide presentation profile and motif of pAnca-UA0101 were confirmed. Based on these results, the proteins of three reptile lizard viruses were used for the screening and confirmation of the candidate epitopes. These data enhance our understanding of the systematic differences between five classes of vertebrates at the gene and protein levels, the formation of the pMHC-I complex, and the evolution of the MHC-I system.
		+
		+	The Crystal Structure of the MHC Class I (MHC-I) Molecule in the Green Anole Lizard Demonstrates the Unique MHC-I System in Reptiles.,Wang Y, Qu Z, Ma L, Wei X, Zhang N, Zhang B, Xia C J Immunol. 2021 Apr 1;206(7):1653-1667. doi: 10.4049/jimmunol.2000992. Epub 2021 , Feb 26. PMID:33637616<ref>PMID:33637616</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7cpo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Anolis carolinensis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z~~-disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Ma L]]
		+	[[Category: Qu Z]]
		+	[[Category: Wang Y]]
		+	[[Category: Wei X]]
		+	[[Category: Xia C]]
		+	[[Category: Zhang N]]

OCA at 07:57, 27 January 2021

OCA — Wed, 27 Jan 2021 07:57:25 GMT

←Older revision		Revision as of 07:57, 27 January 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7cpo ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7cpo' size='340' side='right'caption='[[7cpo]]' scene=''>
-	~~Authors~~: ~~Wang, Y~~.~~, Qu, Z~~.~~, Ma, L~~.~~, Wei, X~~.~~, Zhang, N~~.~~, Xia, C~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Anolis carolinensis MHC I complex~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cpo OCA], [https://pdbe.org/7cpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cpo RCSB], [https://www.ebi.ac.uk/pdbsum/7cpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cpo ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Zhang, N~~]]	+	__TOC__
-	[~~[Category~~: ~~Wang, Y~~]]	+	</StructureSection>
-	[[~~Category~~: ~~Qu, Z~~]]	+	[[Category: Large Structures]]
-	[~~[Category~~: ~~Wei~~, X]]	+	[[Category: Z-disk]]
-	[[Category: ~~Xia, C~~]]	+
-	[[Category: ~~Ma, L~~]]	+

OCA: Protected "7cpo" [edit=sysop:move=sysop]

OCA — Wed, 12 Aug 2020 08:26:32 GMT

Protected "7cpo" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:26, 12 August 2020

OCA: New page: '''Unreleased structure''' The entry 7cpo is ON HOLD Authors: Wang, Y., Qu, Z., Ma, L., Wei, X., Zhang, N., Xia, C. Description: Crystal Structure of Anolis carolinensis MHC I complex ...

OCA — Wed, 12 Aug 2020 08:26:30 GMT

New page: '''Unreleased structure''' The entry 7cpo is ON HOLD Authors: Wang, Y., Qu, Z., Ma, L., Wei, X., Zhang, N., Xia, C. Description: Crystal Structure of Anolis carolinensis MHC I complex ...

New page

'''Unreleased structure'''

The entry 7cpo is ON HOLD

Authors: Wang, Y., Qu, Z., Ma, L., Wei, X., Zhang, N., Xia, C.

Description: Crystal Structure of Anolis carolinensis MHC I complex
[[Category: Unreleased Structures]]
[[Category: Zhang, N]]
[[Category: Wang, Y]]
[[Category: Qu, Z]]
[[Category: Wei, X]]
[[Category: Xia, C]]
[[Category: Ma, L]]