7crf - Revision history

OCA at 16:14, 29 November 2023

OCA — Wed, 29 Nov 2023 16:14:19 GMT

←Older revision		Revision as of 16:14, 29 November 2023
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	<StructureSection load='7crf' size='340' side='right'caption='[[7crf]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='7crf' size='340' side='right'caption='[[7crf]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7crf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CRF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7crf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CRF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GD0:1-[2-(ethoxymethyl)-4-iodanyl-5-phenyl-imidazol-1-yl]-2-methyl-propan-2-ol'>GD0</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.89Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLR8, UNQ249/PRO286 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GD0:1-[2-(ethoxymethyl)-4-iodanyl-5-phenyl-imidazol-1-yl]-2-methyl-propan-2-ol'>GD0</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7crf OCA], [https://pdbe.org/7crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7crf RCSB], [https://www.ebi.ac.uk/pdbsum/7crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7crf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7crf OCA], [https://pdbe.org/7crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7crf RCSB], [https://www.ebi.ac.uk/pdbsum/7crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7crf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>	+	[https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7crf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7crf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Toll-like Receptor 3D structures\|Toll-like Receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ohto, U]]	+	[[Category: Ohto U]]
-	[[Category: Sakaniwa, K]]	+	[[Category: Sakaniwa K]]
-	[[Category: Shimizu, T]]	+	[[Category: Shimizu T]]
-	[[Category: Tanji, H]]	+	[[Category: Tanji H]]
-	~~[[Category: Immune system~~]]	+

OCA at 10:33, 4 August 2021

OCA — Wed, 04 Aug 2021 10:33:37 GMT

←Older revision		Revision as of 10:33, 4 August 2021
Line 1:		Line 1:

	==Crystal structure of human TLR8 in complex with CU-CPD107==		==Crystal structure of human TLR8 in complex with CU-CPD107==
-	<StructureSection load='7crf' size='340' side='right'caption='[[7crf]]' scene=''>	+	<StructureSection load='7crf' size='340' side='right'caption='[[7crf]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CRF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7crf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CRF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7crf OCA], [https://pdbe.org/7crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7crf RCSB], [https://www.ebi.ac.uk/pdbsum/7crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7crf ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GD0:1-[2-(ethoxymethyl)-4-iodanyl-5-phenyl-imidazol-1-yl]-2-methyl-propan-2-ol'>GD0</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TLR8, UNQ249/PRO286 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7crf OCA], [https://pdbe.org/7crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7crf RCSB], [https://www.ebi.ac.uk/pdbsum/7crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7crf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Small-molecule modulators of TLR8 have drawn much interests as it plays pivotal roles in the innate immune response to single-stranded RNAs (ssRNAs) derived from viruses. However, their clinical uses are limited because they can invoke an uncontrolled, global inflammatory response. The efforts described herein culminate in the fortuitous discovery of a tetrasubstituted imidazole CU-CPD107 which inhibits R848-induced TLR8 signaling. In stark contrast, CU-CPD107 shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling. CU-CPD107's unique, dichotomous behavior sheds light on a way to approach TLR agonists. CU-CPD107 offers the opportunity to avoid the undesired, global inflammation side effects that have rendered imidazoquinolines clinically irrelevant, providing an insight for the development of antiviral drugs.
		+
		+	Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists.,Yang Y, Csakai A, Jiang S, Smith C, Tanji H, Huang J, Jones T, Sakaniwa K, Broadwell L, Shi C, Soti S, Ohto U, Fang Y, Shen S, Deng F, Shimizu T, Yin H Nat Commun. 2021 Jul 16;12(1):4351. doi: 10.1038/s41467-021-24536-4. PMID:34272380<ref>PMID:34272380</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7crf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ohto U]]	+	[[Category: Ohto, U]]
-	[[Category: Sakaniwa K]]	+	[[Category: Sakaniwa, K]]
-	[[Category: Shimizu T]]	+	[[Category: Shimizu, T]]
-	[[Category: Tanji H]]	+	[[Category: Tanji, H]]
		+	[[Category: Immune system]]

OCA at 07:29, 25 June 2021

OCA — Fri, 25 Jun 2021 07:29:55 GMT

←Older revision		Revision as of 07:29, 25 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7crf is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human TLR8 in complex with CU-CPD107==
-		+	<StructureSection load='7crf' size='340' side='right'caption='[[7crf]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CRF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7crf OCA], [https://pdbe.org/7crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7crf RCSB], [https://www.ebi.ac.uk/pdbsum/7crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7crf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ohto U]]
		+	[[Category: Sakaniwa K]]
		+	[[Category: Shimizu T]]
		+	[[Category: Tanji H]]

OCA at 05:28, 24 February 2021

OCA — Wed, 24 Feb 2021 05:28:10 GMT

←Older revision		Revision as of 05:28, 24 February 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7crf is ON HOLD	+	The entry 7crf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7crf" [edit=sysop:move=sysop]

OCA — Wed, 19 Aug 2020 04:46:45 GMT

Protected "7crf" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:46, 19 August 2020

OCA: New page: '''Unreleased structure''' The entry 7crf is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Aug 2020 04:46:43 GMT

New page: '''Unreleased structure''' The entry 7crf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7crf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]