7csx - Revision history

OCA at 16:15, 29 November 2023

OCA — Wed, 29 Nov 2023 16:15:46 GMT

←Older revision		Revision as of 16:15, 29 November 2023
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	==Crystal structure of the N-terminal tandem RRM domains of RBM45==		==Crystal structure of the N-terminal tandem RRM domains of RBM45==
-	<StructureSection load='7csx' size='340' side='right'caption='[[7csx]]' scene=''>	+	<StructureSection load='7csx' size='340' side='right'caption='[[7csx]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7csx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csx OCA], [https://pdbe.org/7csx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csx RCSB], [https://www.ebi.ac.uk/pdbsum/7csx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csx OCA], [https://pdbe.org/7csx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csx RCSB], [https://www.ebi.ac.uk/pdbsum/7csx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RBM45_HUMAN RBM45_HUMAN] RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.[UniProtKB:Q8CFD1]<ref>PMID:12220514</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RBM45 is an RNA-binding protein involved in neural development, whose aggregation is associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). However, the mechanisms of RNA-binding and aggregation of RBM45 remain unelucidated. Here, we report the crystal structure of the N-terminal tandem RRM domains of human RBM45 in complex with single-stranded DNA (ssDNA). Our structural and biochemical results revealed that both the RRM1 and RRM2 of RBM45 recognized the GAC sequence of RNA/ssDNA. Two aromatic residues and an arginine residue in each RRM were critical for RNA-binding, and the interdomain linker was also involved in RNA-binding. Two RRMs formed a pair of antiparallel RNA-binding sites, indicating that the N-terminal tandem RRM domains of RBM45 bound separate GAC motifs in one RNA strand or GAC motifs in different RNA strands. Our findings will be helpful in the identification of physiologic targets of RBM45 and provide evidence for understanding the physiologic and pathologic functions of RBM45.
		+
		+	Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45.,Chen X, Yang Z, Wang W, Qian K, Liu M, Wang J, Wang M Nucleic Acids Res. 2021 Mar 18;49(5):2946-2958. doi: 10.1093/nar/gkab075. PMID:33577684<ref>PMID:33577684</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7csx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen X]]		[[Category: Chen X]]

OCA at 11:10, 3 February 2021

OCA — Wed, 03 Feb 2021 11:10:44 GMT

←Older revision		Revision as of 11:10, 3 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7csx is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the N-terminal tandem RRM domains of RBM45==
-		+	<StructureSection load='7csx' size='340' side='right'caption='[[7csx]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSX FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csx OCA], [https://pdbe.org/7csx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csx RCSB], [https://www.ebi.ac.uk/pdbsum/7csx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen X]]
		+	[[Category: Wang M]]
		+	[[Category: Wang W]]
		+	[[Category: Yang Z]]

OCA at 05:11, 2 September 2020

OCA — Wed, 02 Sep 2020 05:11:28 GMT

←Older revision		Revision as of 05:11, 2 September 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7csx is ON HOLD	+	The entry 7csx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7csx" [edit=sysop:move=sysop]

OCA — Wed, 26 Aug 2020 09:26:39 GMT

Protected "7csx" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:26, 26 August 2020

OCA: New page: '''Unreleased structure''' The entry 7csx is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Aug 2020 09:26:38 GMT

New page: '''Unreleased structure''' The entry 7csx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7csx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]