OCA at 16:17, 29 November 2023

OCA — Wed, 29 Nov 2023 16:17:48 GMT

←Older revision		Revision as of 16:17, 29 November 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7cx0 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis in complex with the cofactor PLP and inhibitor carbidopa==
-		+	<StructureSection load='7cx0' size='340' side='right'caption='[[7cx0]], [[Resolution\|resolution]] 2.66Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7cx0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CX0 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.66Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=142:CARBIDOPA'>142</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cx0 OCA], [https://pdbe.org/7cx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cx0 RCSB], [https://www.ebi.ac.uk/pdbsum/7cx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cx0 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TYRDC_ENTFA TYRDC_ENTFA] Catalyzes the decarboxylation of L-tyrosine to produce tyramine (PubMed:30659181). Plays a role in acid resistance since tyramine production via tyrosine decarboxylation appears to provide a cytosolic pH maintenance mechanism that helps the bacterium cope with acid stress such as that encountered in gastrointestinal tract (GIT) environments. Therefore, may contribute to the colonization of the human GIT by E.faecalis (PubMed:25529314).<ref>PMID:25529314</ref> <ref>PMID:30659181</ref> Also involved in drug metabolism, being able to catalyze decarboxylation of levodopa (L-dopa) to dopamine. In gut microbiota this enzyme is in fact exclusively responsible for the decarboxylation of levodopa, and thus reduces in situ levels of levodopa in the treatment of Parkinson's disease. It was shown that abundance of bacterial tyrosine decarboxylase in the proximal small intestine - the primary site of levodopa absorption - contributes to interindividual variation in drug efficacy and can explain the requirement for an increased dosage regimen of levodopa treatment in Parkinson's disease patients.<ref>PMID:30659181</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Enterococcus faecalis]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen C]]
		+	[[Category: Gong M]]
		+	[[Category: Guo R]]
		+	[[Category: Huang J]]
		+	[[Category: Liu W]]
		+	[[Category: Yu X]]

OCA at 13:12, 3 March 2021

OCA — Wed, 03 Mar 2021 13:12:14 GMT

←Older revision		Revision as of 13:12, 3 March 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7cx0 is ON HOLD	+	The entry 7cx0 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7cx0" [edit=sysop:move=sysop]

OCA — Wed, 09 Sep 2020 07:33:32 GMT

Protected "7cx0" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:33, 9 September 2020

OCA: New page: '''Unreleased structure''' The entry 7cx0 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 09 Sep 2020 07:33:29 GMT

New page: '''Unreleased structure''' The entry 7cx0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7cx0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7cx0 - Revision history

OCA at 16:17, 29 November 2023

OCA at 13:12, 3 March 2021

OCA: Protected "7cx0" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7cx0 is ON HOLD Authors: Description: Category: Unreleased Structures