7drb - Revision history

OCA at 16:38, 29 November 2023

OCA — Wed, 29 Nov 2023 16:38:32 GMT

←Older revision		Revision as of 16:38, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7drb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_benthamiana Nicotiana benthamiana] and [https://en.wikipedia.org/wiki/Phytophthora_sojae Phytophthora sojae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DRB FirstGlance]. <br>		<table><tr><td colspan='2'>[[7drb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_benthamiana Nicotiana benthamiana] and [https://en.wikipedia.org/wiki/Phytophthora_sojae Phytophthora sojae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DRB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7drb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7drb OCA], [https://pdbe.org/7drb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7drb RCSB], [https://www.ebi.ac.uk/pdbsum/7drb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7drb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7drb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7drb OCA], [https://pdbe.org/7drb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7drb RCSB], [https://www.ebi.ac.uk/pdbsum/7drb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7drb ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:21, 26 October 2022

OCA — Wed, 26 Oct 2022 06:21:59 GMT

←Older revision		Revision as of 06:21, 26 October 2022
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-	====	+	==Crystal structure of plant receptor like protein RXEG1 with xyloglucanase XEG1==
-	<StructureSection load='7drb' size='340' side='right'caption='[[7drb]]' scene=''>	+	<StructureSection load='7drb' size='340' side='right'caption='[[7drb]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7drb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_benthamiana Nicotiana benthamiana] and [https://en.wikipedia.org/wiki/Phytophthora_sojae Phytophthora sojae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DRB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7drb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7drb OCA], [https://pdbe.org/7drb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7drb RCSB], [https://www.ebi.ac.uk/pdbsum/7drb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7drb ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7drb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7drb OCA], [https://pdbe.org/7drb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7drb RCSB], [https://www.ebi.ac.uk/pdbsum/7drb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7drb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q30BZ2_PHYSO Q30BZ2_PHYSO]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plants rely on cell-surface-localized pattern recognition receptors to detect pathogen- or host-derived danger signals and trigger an immune response(1-6). Receptor-like proteins (RLPs) with a leucine-rich repeat (LRR) ectodomain constitute a subgroup of pattern recognition receptors and play a critical role in plant immunity(1-3). Mechanisms underlying ligand recognition and activation of LRR-RLPs remain elusive. Here we report a crystal structure of the LRR-RLP RXEG1 from Nicotiana benthamiana that recognizes XEG1 xyloglucanase from the pathogen Phytophthora sojae. The structure reveals that specific XEG1 recognition is predominantly mediated by an amino-terminal and a carboxy-terminal loop-out region (RXEG1(ID)) of RXEG1. The two loops bind to the active-site groove of XEG1, inhibiting its enzymatic activity and suppressing Phytophthora infection of N. benthamiana. Binding of XEG1 promotes association of RXEG1(LRR) with the LRR-type co-receptor BAK1 through RXEG1(ID) and the last four conserved LRRs to trigger RXEG1-mediated immune responses. Comparison of the structures of apo-RXEG1(LRR), XEG1-RXEG1(LRR) and XEG1-BAK1-RXEG1(LRR) shows that binding of XEG1 induces conformational changes in the N-terminal region of RXEG1(ID) and enhances structural flexibility of the BAK1-associating regions of RXEG1(LRR). These changes allow fold switching of RXEG1(ID) for recruitment of BAK1(LRR). Our data reveal a conserved mechanism of ligand-induced heterodimerization of an LRR-RLP with BAK1 and suggest a dual function for the LRR-RLP in plant immunity.
		+
		+	Plant receptor-like protein activation by a microbial glycoside hydrolase.,Sun Y, Wang Y, Zhang X, Chen Z, Xia Y, Wang L, Sun Y, Zhang M, Xiao Y, Han Z, Wang Y, Chai J Nature. 2022 Oct;610(7931):335-342. doi: 10.1038/s41586-022-05214-x. Epub 2022, Sep 21. PMID:36131021<ref>PMID:36131021</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7drb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Nicotiana benthamiana]]
		+	[[Category: Phytophthora sojae]]
		+	[[Category: Chai JJ]]
		+	[[Category: Chen ZD]]
		+	[[Category: Han ZF]]
		+	[[Category: Sun Y]]
		+	[[Category: Sun YJ]]
		+	[[Category: Wang Y]]
		+	[[Category: Wang YC]]
		+	[[Category: Xia YQ]]
		+	[[Category: Xiao Y]]
		+	[[Category: Zhang MM]]
		+	[[Category: Zhang XX]]

OCA at 09:42, 22 June 2022

OCA — Wed, 22 Jun 2022 09:42:51 GMT

←Older revision		Revision as of 09:42, 22 June 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7drb ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7drb' size='340' side='right'caption='[[7drb]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7drb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7drb OCA], [https://pdbe.org/7drb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7drb RCSB], [https://www.ebi.ac.uk/pdbsum/7drb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7drb ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:39, 12 May 2022

OCA — Thu, 12 May 2022 04:39:53 GMT

←Older revision		Revision as of 04:39, 12 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7drb is ON HOLD ~~until Jun 27 2023~~	+	The entry 7drb is ON HOLD

	Authors:		Authors:

OCA at 10:19, 27 April 2022

OCA — Wed, 27 Apr 2022 10:19:12 GMT

←Older revision		Revision as of 10:19, 27 April 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7drb is ON HOLD	+	The entry 7drb is ON HOLD until Jun 27 2023

	Authors:		Authors:

OCA at 08:30, 13 April 2022

OCA — Wed, 13 Apr 2022 08:30:08 GMT

←Older revision		Revision as of 08:30, 13 April 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7drb is ON HOLD ~~until Paper Publication~~	+	The entry 7drb is ON HOLD

	Authors:		Authors:

OCA at 12:29, 27 October 2021

OCA — Wed, 27 Oct 2021 12:29:38 GMT

←Older revision		Revision as of 12:29, 27 October 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7drb is ON HOLD	+	The entry 7drb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7drb" [edit=sysop:move=sysop]

OCA — Wed, 06 Jan 2021 05:37:39 GMT

Protected "7drb" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 6 January 2021

OCA: New page: '''Unreleased structure''' The entry 7drb is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Jan 2021 05:37:36 GMT

New page: '''Unreleased structure''' The entry 7drb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7drb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]