7dro - Revision history

OCA at 16:38, 29 November 2023

OCA — Wed, 29 Nov 2023 16:38:37 GMT

←Older revision		Revision as of 16:38, 29 November 2023
Line 1:		Line 1:

-	====	+	==Structure of ATP-grasp ligase PsnB complexed with minimal precursor==
-	<StructureSection load='7dro' size='340' side='right'caption='[[7dro]]' scene=''>	+	<StructureSection load='7dro' size='340' side='right'caption='[[7dro]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7dro]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Plesiocystis_pacifica_SIR-1 Plesiocystis pacifica SIR-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DRO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dro OCA], [https://pdbe.org/7dro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dro RCSB], [https://www.ebi.ac.uk/pdbsum/7dro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dro ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.25Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dro OCA], [https://pdbe.org/7dro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dro RCSB], [https://www.ebi.ac.uk/pdbsum/7dro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dro ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A6G4D7_9DELT A6G4D7_9DELT]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Graspetides, also known as omega-ester-containing peptides (OEPs), are a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) bearing side chain-to-side chain macrolactone or macrolactam linkages. Here, we present the molecular details of precursor peptide recognition by the macrocyclase enzyme PsnB in the biosynthesis of plesiocin, a group 2 graspetide. Biochemical analysis revealed that, in contrast to other RiPPs, the core region of the plesiocin precursor peptide noticeably enhanced the enzyme-precursor interaction via the conserved glutamate residues. We obtained four crystal structures of symmetric or asymmetric PsnB dimers, including those with a bound core peptide and a nucleotide, and suggest that the highly conserved Arg213 at the enzyme active site specifically recognizes a ring-forming acidic residue before phosphorylation. Collectively, this study provides insights into the mechanism underlying substrate recognition in graspetide biosynthesis and lays a foundation for engineering new variants.
		+
		+	Molecular mechanism underlying substrate recognition of the peptide macrocyclase PsnB.,Song I, Kim Y, Yu J, Go SY, Lee HG, Song WJ, Kim S Nat Chem Biol. 2021 Nov;17(11):1123-1131. doi: 10.1038/s41589-021-00855-x. Epub , 2021 Sep 2. PMID:34475564<ref>PMID:34475564</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7dro" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Plesiocystis pacifica SIR-1]]
		+	[[Category: Kim S]]
		+	[[Category: Song I]]
		+	[[Category: Song W]]
		+	[[Category: Yu J]]

OCA at 08:56, 8 September 2021

OCA — Wed, 08 Sep 2021 08:56:38 GMT

←Older revision		Revision as of 08:56, 8 September 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7dro ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7dro' size='340' side='right'caption='[[7dro]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dro OCA], [https://pdbe.org/7dro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dro RCSB], [https://www.ebi.ac.uk/pdbsum/7dro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dro ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 08:02, 12 May 2021

OCA — Wed, 12 May 2021 08:02:10 GMT

←Older revision		Revision as of 08:02, 12 May 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7dro is ON HOLD	+	The entry 7dro is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 07:14, 5 May 2021

OCA — Wed, 05 May 2021 07:14:47 GMT

←Older revision		Revision as of 07:14, 5 May 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7dro is ON HOLD ~~until Paper Publication~~	+	The entry 7dro is ON HOLD

	Authors:		Authors:

OCA at 06:46, 20 January 2021

OCA — Wed, 20 Jan 2021 06:46:55 GMT

←Older revision		Revision as of 06:46, 20 January 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7dro is ON HOLD	+	The entry 7dro is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7dro" [edit=sysop:move=sysop]

OCA — Wed, 06 Jan 2021 05:39:17 GMT

Protected "7dro" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:39, 6 January 2021

OCA: New page: '''Unreleased structure''' The entry 7dro is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Jan 2021 05:39:15 GMT

New page: '''Unreleased structure''' The entry 7dro is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7dro is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]