7dsf - Revision history

OCA at 16:38, 29 November 2023

OCA — Wed, 29 Nov 2023 16:38:55 GMT

←Older revision		Revision as of 16:38, 29 November 2023
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	==The Crystal Structure of human SPR from Biortus.==		==The Crystal Structure of human SPR from Biortus.==
-	<StructureSection load='7dsf' size='340' side='right'caption='[[7dsf]]' scene=''>	+	<StructureSection load='7dsf' size='340' side='right'caption='[[7dsf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DSF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7DSF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7dsf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DSF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7dsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dsf OCA], [~~http~~://pdbe.org/7dsf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7dsf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7dsf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7dsf ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dsf OCA], [https://pdbe.org/7dsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dsf RCSB], [https://www.ebi.ac.uk/pdbsum/7dsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dsf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN] Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:[https://omim.org/entry/612716 612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.<ref>PMID:11443547</ref> <ref>PMID:16650784</ref> <ref>PMID:17159114</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN] Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cheng W]]		[[Category: Cheng W]]

OCA at 05:55, 20 January 2021

OCA — Wed, 20 Jan 2021 05:55:54 GMT

←Older revision		Revision as of 05:55, 20 January 2021
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-	'''Unreleased structure'''

-	The ~~entry~~ 7dsf ~~is ON HOLD~~	+	==The Crystal Structure of human SPR from Biortus.==
-		+	<StructureSection load='7dsf' size='340' side='right'caption='[[7dsf]]' scene=''>
-	~~Authors~~: ~~Wang, F~~.~~, Lv, Z~~., ~~Cheng, W~~.~~, Lin, D~~., ~~Meng, Q~~., ~~Zhang~~, B., ~~Huang, Y~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DSF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7DSF FirstGlance]. <br>
-	~~Description: The Crystal Structure of human SPR from Biortus.~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7dsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dsf OCA], [http://pdbe.org/7dsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7dsf RCSB], [http://www.ebi.ac.uk/pdbsum/7dsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7dsf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Zhang, B~~]]	+	__TOC__
-	[[Category: ~~Lin, D~~]]	+	</StructureSection>
-	[[Category: ~~Wang, F~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Meng, Q~~]]	+	[[Category: Cheng W]]
-	[[Category: ~~Lv, Z~~]]	+	[[Category: Huang Y]]
-	[[Category: ~~Cheng, W~~]]	+	[[Category: Lin D]]
-	[[Category: ~~Huang, Y~~]]	+	[[Category: Lv Z]]
		+	[[Category: Meng Q]]
		+	[[Category: Wang F]]
		+	[[Category: Zhang B]]

OCA: Protected "7dsf" [edit=sysop:move=sysop]

OCA — Wed, 06 Jan 2021 05:42:46 GMT

Protected "7dsf" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 6 January 2021

OCA: New page: '''Unreleased structure''' The entry 7dsf is ON HOLD Authors: Wang, F., Lv, Z., Cheng, W., Lin, D., Meng, Q., Zhang, B., Huang, Y. Description: The Crystal Structure of human SPR from ...

OCA — Wed, 06 Jan 2021 05:42:43 GMT

New page: '''Unreleased structure''' The entry 7dsf is ON HOLD Authors: Wang, F., Lv, Z., Cheng, W., Lin, D., Meng, Q., Zhang, B., Huang, Y. Description: The Crystal Structure of human SPR from ...

New page

'''Unreleased structure'''

The entry 7dsf is ON HOLD

Authors: Wang, F., Lv, Z., Cheng, W., Lin, D., Meng, Q., Zhang, B., Huang, Y.

Description: The Crystal Structure of human SPR from Biortus.
[[Category: Unreleased Structures]]
[[Category: Zhang, B]]
[[Category: Lin, D]]
[[Category: Wang, F]]
[[Category: Meng, Q]]
[[Category: Lv, Z]]
[[Category: Cheng, W]]
[[Category: Huang, Y]]