7duu - Revision history

OCA at 16:39, 29 November 2023

OCA — Wed, 29 Nov 2023 16:39:52 GMT

←Older revision		Revision as of 16:39, 29 November 2023
Line 1:		Line 1:

-	====	+	==Crystal structure of HLA molecule with an KIR receptor==
-	<StructureSection load='7duu' size='340' side='right'caption='[[7duu]]' scene=''>	+	<StructureSection load='7duu' size='340' side='right'caption='[[7duu]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7duu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DUU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7duu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7duu OCA], [https://pdbe.org/7duu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7duu RCSB], [https://www.ebi.ac.uk/pdbsum/7duu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7duu ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7duu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7duu OCA], [https://pdbe.org/7duu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7duu RCSB], [https://www.ebi.ac.uk/pdbsum/7duu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7duu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F6IQA6_HUMAN F6IQA6_HUMAN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Killer cell immunoglobulin-like receptors (KIRs) are important receptors for regulating the killing of virus-infected or cancer cells of natural killer (NK) cells. KIR2DS2 can recognize peptides derived from hepatitis C virus (HCV) or global flaviviruses (such as dengue and Zika) presented by HLA-C0102 to activate NK cells, and has shown promising results when used for cancer immunotherapy. Here, we present the complex structure of KIR2DS2 with HLA-C0102 at a resolution of 2.5A. Our structure reveals that KIR2DS2 can bind with HLA-C0102 and HLA-A1101 in two different directions. Moreover, Tyr45 (in activating receptor KIR2DS2) and Phe45 (in inhibitory KIRs) distinguish the two different binding models and binding affinity between activating KIRs and inhibitory KIRs. The conserved 'AT' motif of the peptide mediates recognition and determines the peptide specificity of recognition. These structural characteristics shed light on how KIRs activate NK cells and can provide a molecular basis for immunotherapy by NK cells.
		+
		+	Activating receptor KIR2DS2 bound to HLA-C1 reveals the novel recognition features of activating receptor.,Yang Y, Bai H, Wu Y, Chen P, Zhou J, Lei J, Ye X, Brown AJ, Zhou X, Shu T, Chen Y, Wei P, Yin L Immunology. 2022 Mar;165(3):341-354. doi: 10.1111/imm.13439. Epub 2022 Jan 11. PMID:34967442<ref>PMID:34967442</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7duu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
		+	*[[NK cell receptor\|NK cell receptor]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hepacivirus C]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Yang Y]]
		+	[[Category: Yin L]]

OCA at 06:58, 2 February 2022

OCA — Wed, 02 Feb 2022 06:58:13 GMT

←Older revision		Revision as of 06:58, 2 February 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7duu ~~is ON HOLD until Jul 11 2023~~	+	====
-		+	<StructureSection load='7duu' size='340' side='right'caption='[[7duu]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7duu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7duu OCA], [https://pdbe.org/7duu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7duu RCSB], [https://www.ebi.ac.uk/pdbsum/7duu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7duu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 10:43, 24 November 2021

OCA — Wed, 24 Nov 2021 10:43:49 GMT

←Older revision		Revision as of 10:43, 24 November 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7duu is ON HOLD until ~~Paper Publication~~	+	The entry 7duu is ON HOLD until Jul 11 2023

	Authors:		Authors:

OCA at 05:24, 22 September 2021

OCA — Wed, 22 Sep 2021 05:24:28 GMT

←Older revision		Revision as of 05:24, 22 September 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7duu is ON HOLD	+	The entry 7duu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7duu" [edit=sysop:move=sysop]

OCA — Wed, 20 Jan 2021 06:48:31 GMT

Protected "7duu" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:48, 20 January 2021

OCA: New page: '''Unreleased structure''' The entry 7duu is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jan 2021 06:48:30 GMT

New page: '''Unreleased structure''' The entry 7duu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7duu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]