OCA at 16:40, 29 November 2023

OCA — Wed, 29 Nov 2023 16:40:40 GMT

←Older revision		Revision as of 16:40, 29 November 2023
Line 1:		Line 1:

-	====	+	==Heme sensor protein PefR from Streptococcus agalactiae bound to operator DNA (28-mer)==
-	<StructureSection load='7dvv' size='340' side='right'caption='[[7dvv]]' scene=''>	+	<StructureSection load='7dvv' size='340' side='right'caption='[[7dvv]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7dvv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae_NEM316 Streptococcus agalactiae NEM316]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DVV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dvv OCA], [https://pdbe.org/7dvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dvv RCSB], [https://www.ebi.ac.uk/pdbsum/7dvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dvv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.49Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dvv OCA], [https://pdbe.org/7dvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dvv RCSB], [https://www.ebi.ac.uk/pdbsum/7dvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dvv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8E4J9_STRA3 Q8E4J9_STRA3]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hemes (iron-porphyrins) are critical for biological processes in all organisms. Hemolytic bacteria survive by acquiring b-type heme from hemoglobin in red blood cells from their animal hosts. These bacteria avoid the cytotoxicity of excess heme during hemolysis by expressing heme-responsive sensor proteins that act as transcriptional factors to regulate the heme efflux system in response to the cellular heme concentration. Here, the underlying regulatory mechanisms were investigated using crystallographic, spectroscopic, and biochemical studies to understand the structural basis of the heme-responsive sensor protein PefR from Streptococcus agalactiae, a causative agent of neonatal life-threatening infections. Structural comparison of heme-free PefR, its complex with a target DNA, and heme-bound PefR revealed that unique heme coordination controls a >20 A structural rearrangement of the DNA binding domains to dissociate PefR from the target DNA. We also found heme-bound PefR stably binds exogenous ligands, including carbon monoxide, a by-product of the heme degradation reaction.
		+
		+	Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival.,Nishinaga M, Sugimoto H, Nishitani Y, Nagai S, Nagatoishi S, Muraki N, Tosha T, Tsumoto K, Aono S, Shiro Y, Sawai H Commun Biol. 2021 Apr 13;4(1):467. doi: 10.1038/s42003-021-01987-5. PMID:33850260<ref>PMID:33850260</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7dvv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Streptococcus agalactiae NEM316]]
		+	[[Category: Nagai S]]
		+	[[Category: Nishinaga M]]
		+	[[Category: Nishitani Y]]
		+	[[Category: Sawai H]]
		+	[[Category: Shiro Y]]
		+	[[Category: Sugimoto H]]

OCA at 08:48, 29 September 2021

OCA — Wed, 29 Sep 2021 08:48:35 GMT

←Older revision		Revision as of 08:48, 29 September 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7dvv ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7dvv' size='340' side='right'caption='[[7dvv]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dvv OCA], [https://pdbe.org/7dvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dvv RCSB], [https://www.ebi.ac.uk/pdbsum/7dvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dvv ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:07, 10 February 2021

OCA — Wed, 10 Feb 2021 09:07:09 GMT

←Older revision		Revision as of 09:07, 10 February 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7dvv is ON HOLD	+	The entry 7dvv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7dvv" [edit=sysop:move=sysop]

OCA — Wed, 20 Jan 2021 06:50:08 GMT

Protected "7dvv" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:50, 20 January 2021

OCA: New page: '''Unreleased structure''' The entry 7dvv is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jan 2021 06:50:07 GMT

New page: '''Unreleased structure''' The entry 7dvv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7dvv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7dvv - Revision history

OCA at 16:40, 29 November 2023

OCA at 08:48, 29 September 2021

OCA at 09:07, 10 February 2021

OCA: Protected "7dvv" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7dvv is ON HOLD Authors: Description: Category: Unreleased Structures