7e9o - Revision history

OCA at 07:51, 21 September 2022

OCA — Wed, 21 Sep 2022 07:51:59 GMT

←Older revision		Revision as of 07:51, 21 September 2022
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-	====	+	==Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(3 up RBDs, state2)==
-	<StructureSection load='7e9o' size='340' side='right'caption='[[7e9o]]' scene=''>	+	<StructureSection load='7e9o' size='340' side='right'caption='[[7e9o]], [[Resolution\|resolution]] 3.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7e9o]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E9O FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e9o OCA], [https://pdbe.org/7e9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e9o RCSB], [https://www.ebi.ac.uk/pdbsum/7e9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e9o ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e9o OCA], [https://pdbe.org/7e9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e9o RCSB], [https://www.ebi.ac.uk/pdbsum/7e9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e9o ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Wang XF]]
		+	[[Category: Zhu YQ]]

OCA at 06:04, 9 March 2022

OCA — Wed, 09 Mar 2022 06:04:32 GMT

←Older revision		Revision as of 06:04, 9 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7e9o ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7e9o' size='340' side='right'caption='[[7e9o]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e9o OCA], [https://pdbe.org/7e9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e9o RCSB], [https://www.ebi.ac.uk/pdbsum/7e9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e9o ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 07:15, 5 May 2021

OCA — Wed, 05 May 2021 07:15:20 GMT

←Older revision		Revision as of 07:15, 5 May 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7e9o is ON HOLD	+	The entry 7e9o is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7e9o" [edit=sysop:move=sysop]

OCA — Wed, 10 Mar 2021 14:36:55 GMT

Protected "7e9o" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:36, 10 March 2021

OCA: New page: '''Unreleased structure''' The entry 7e9o is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Mar 2021 14:36:54 GMT

New page: '''Unreleased structure''' The entry 7e9o is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7e9o is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]