7ehe - Revision history

OCA at 16:53, 29 November 2023

OCA — Wed, 29 Nov 2023 16:53:36 GMT

←Older revision		Revision as of 16:53, 29 November 2023
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	==Acetolactate Synthase from Trichoderma harzianum==		==Acetolactate Synthase from Trichoderma harzianum==
-	<StructureSection load='7ehe' size='340' side='right'caption='[[7ehe]]' scene=''>	+	<StructureSection load='7ehe' size='340' side='right'caption='[[7ehe]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EHE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ehe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_harzianum Trichoderma harzianum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EHE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ehe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ehe OCA], [https://pdbe.org/7ehe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ehe RCSB], [https://www.ebi.ac.uk/pdbsum/7ehe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ehe ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.28Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TZD:2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL+TRIHYDROGEN+DIPHOSPHATE'>TZD</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ehe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ehe OCA], [https://pdbe.org/7ehe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ehe RCSB], [https://www.ebi.ac.uk/pdbsum/7ehe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ehe ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2N1LPC4_TRIHA A0A2N1LPC4_TRIHA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acetohydroxyacid synthase (AHAS) is the first enzyme in the branched-chain amino acid biosynthetic pathway and is a validated target for herbicide and fungicide development. Here we report harzianic acid (HA, 1) produced by the biocontrol fungus Trichoderma afroharzianum t-22 (Tht22) as a natural product inhibitor of AHAS. The biosynthetic pathway of HA was elucidated with heterologous reconstitution. Guided by a putative self-resistance enzyme in the genome, HA was biochemically demonstrated to be a selective inhibitor of fungal AHAS, including those from phytopathogenic fungi. In addition, HA can inhibit a common resistant variant of AHAS in which the active site proline is mutated. Structural analysis of AHAS complexed with HA revealed the molecular basis of competitive inhibition, which differs from all known commercial AHAS inhibitors. The alternative binding mode also rationalizes the selectivity of HA, as well as effectiveness toward resistant mutants. A proposed role of HA biosynthesis by Tht22 in the rhizosphere is discussed based on the data.
		+
		+	Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase.,Xie L, Zang X, Cheng W, Zhang Z, Zhou J, Chen M, Tang Y J Am Chem Soc. 2021 Jun 16. doi: 10.1021/jacs.1c03988. PMID:34132537<ref>PMID:34132537</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ehe" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Trichoderma harzianum]]
	[[Category: Tang Y]]		[[Category: Tang Y]]
	[[Category: Zang X]]		[[Category: Zang X]]
	[[Category: Zhou J]]		[[Category: Zhou J]]

OCA at 03:33, 2 July 2021

OCA — Fri, 02 Jul 2021 03:33:24 GMT

←Older revision		Revision as of 03:33, 2 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ehe ~~is ON HOLD until Paper Publication~~	+	==Acetolactate Synthase from Trichoderma harzianum==
-		+	<StructureSection load='7ehe' size='340' side='right'caption='[[7ehe]]' scene=''>
-	~~Authors~~: ~~Zang~~, X., ~~Tang~~, Y., ~~Zhou~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EHE FirstGlance]. <br>
-	~~Description: Acetolactate Synthase from Trichoderma harzianum~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ehe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ehe OCA], [https://pdbe.org/7ehe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ehe RCSB], [https://www.ebi.ac.uk/pdbsum/7ehe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ehe ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Tang, Y]]	+	__TOC__
-	[[Category: Zang, X]]	+	</StructureSection>
-	[[Category: Zhou, J]]	+	[[Category: Large Structures]]
		+	[[Category: Tang Y]]
		+	[[Category: Zang X]]
		+	[[Category: Zhou J]]

OCA at 04:10, 28 April 2021

OCA — Wed, 28 Apr 2021 04:10:50 GMT

←Older revision		Revision as of 04:10, 28 April 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ehe is ON HOLD	+	The entry 7ehe is ON HOLD until Paper Publication

	Authors: Zang, X., Tang, Y., Zhou, J.		Authors: Zang, X., Tang, Y., Zhou, J.

OCA: Protected "7ehe" [edit=sysop:move=sysop]

OCA — Wed, 07 Apr 2021 04:30:43 GMT

Protected "7ehe" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:30, 7 April 2021

OCA: New page: '''Unreleased structure''' The entry 7ehe is ON HOLD Authors: Zang, X., Tang, Y., Zhou, J. Description: Acetolactate Synthase from Trichoderma harzianum [[Category: Unreleased Structur...

OCA — Wed, 07 Apr 2021 04:30:42 GMT

New page: '''Unreleased structure''' The entry 7ehe is ON HOLD Authors: Zang, X., Tang, Y., Zhou, J. Description: Acetolactate Synthase from Trichoderma harzianum [[Category: Unreleased Structur...

New page

'''Unreleased structure'''

The entry 7ehe is ON HOLD

Authors: Zang, X., Tang, Y., Zhou, J.

Description: Acetolactate Synthase from Trichoderma harzianum
[[Category: Unreleased Structures]]
[[Category: Tang, Y]]
[[Category: Zang, X]]
[[Category: Zhou, J]]