OCA at 16:55, 29 November 2023

OCA — Wed, 29 Nov 2023 16:55:32 GMT

←Older revision		Revision as of 16:55, 29 November 2023
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	==prawn ferritin to coordinate with heavy metal ions==		==prawn ferritin to coordinate with heavy metal ions==
-	<StructureSection load='7ek5' size='340' side='right'caption='[[7ek5]]' scene=''>	+	<StructureSection load='7ek5' size='340' side='right'caption='[[7ek5]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EK5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ek5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Penaeus_japonicus Penaeus japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EK5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ek5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ek5 OCA], [https://pdbe.org/7ek5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ek5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ek5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ek5 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ek5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ek5 OCA], [https://pdbe.org/7ek5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ek5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ek5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ek5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/T2B7E1_PENJP T2B7E1_PENJP] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although apoferritin has been widely utilized as a new class of natural protein nanovehicles for encapsulation and delivery of nutraceuticals, its ability to remove metal heavy ions has yet to be explored. In this study, for the first time, we demonstrated that the ferritin from kuruma prawns (Marsupenaeus japonicus), named MjF, has a pronouncedly larger ability to resist denaturation induced by Cd(2+) and Hg(2+) as compared to its analogue, human H-chain ferritin (HuHF), despite the fact that these two proteins share a high similarity in protein structure. Treatment of HuHF with Cd(2+) or Hg(2+) at a metal ion/protein shell ratio of 100/1 resulted in marked protein aggregation, while the MjF solution was kept constantly clear upon treatment with Cd(2+) and Hg(2+) at different protein shell/metal ion ratios (50/1, 100/1, 250/1, 500/1, 1000/1, and 2500/1). Structural comparison analyses in conjunction with the newly solved crystal structure of the complex of MjF plus Cd(2+) or Hg(2+) revealed that cysteine (Cys) is a major residue responsible for such binding, and that the large difference in the ability to resist denaturation induced by these two heavy metal ions between MjF and HuHF is mainly derived from the different positions of Cys residues in these two proteins; namely, Cys residues in HuHF are located on the outer surface, while Cys residues from MjF are buried within the protein shell. All of these findings raise the high possibility that prawn ferritin, as a food-derived protein, could be developed into a novel bio-template to remove heavy metal ions from contaminated food systems.
		+
		+	Structural Insights for the Stronger Ability of Shrimp Ferritin to Coordinate with Heavy Metal Ions as Compared to Human H-Chain Ferritin.,Wang Y, Zang J, Wang C, Zhang X, Zhao G Int J Mol Sci. 2021 Jul 23;22(15). pii: ijms22157859. doi: 10.3390/ijms22157859. PMID:34360624<ref>PMID:34360624</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ek5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Penaeus japonicus]]
	[[Category: Wang Y]]		[[Category: Wang Y]]
	[[Category: Zang J]]		[[Category: Zang J]]

OCA at 14:07, 29 December 2021

OCA — Wed, 29 Dec 2021 14:07:54 GMT

←Older revision		Revision as of 14:07, 29 December 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7ek5 ~~is ON HOLD until Apr 03 2023~~	+	==prawn ferritin to coordinate with heavy metal ions==
-		+	<StructureSection load='7ek5' size='340' side='right'caption='[[7ek5]]' scene=''>
-	~~Authors~~: ~~Wang~~, Y., ~~Zang~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EK5 FirstGlance]. <br>
-	~~Description: prawn ferritin to coordinate with heavy metal ions~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ek5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ek5 OCA], [https://pdbe.org/7ek5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ek5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ek5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ek5 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Zang, J~~]]	+	__TOC__
-	[[Category: ~~Wang, Y~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Wang Y]]
		+	[[Category: Zang J]]

OCA at 07:16, 5 May 2021

OCA — Wed, 05 May 2021 07:16:52 GMT

←Older revision		Revision as of 07:16, 5 May 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ek5 is ON HOLD	+	The entry 7ek5 is ON HOLD until Apr 03 2023

	Authors: Wang, Y., Zang, J.		Authors: Wang, Y., Zang, J.

OCA: Protected "7ek5" [edit=sysop:move=sysop]

OCA — Wed, 14 Apr 2021 05:35:21 GMT

Protected "7ek5" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:35, 14 April 2021

OCA: New page: '''Unreleased structure''' The entry 7ek5 is ON HOLD Authors: Wang, Y., Zang, J. Description: prawn ferritin to coordinate with heavy metal ions Category: Unreleased Structures [[C...

OCA — Wed, 14 Apr 2021 05:35:21 GMT

New page: '''Unreleased structure''' The entry 7ek5 is ON HOLD Authors: Wang, Y., Zang, J. Description: prawn ferritin to coordinate with heavy metal ions Category: Unreleased Structures [[C...

New page

'''Unreleased structure'''

The entry 7ek5 is ON HOLD

Authors: Wang, Y., Zang, J.

Description: prawn ferritin to coordinate with heavy metal ions
[[Category: Unreleased Structures]]
[[Category: Zang, J]]
[[Category: Wang, Y]]

7ek5 - Revision history

OCA at 16:55, 29 November 2023

OCA at 14:07, 29 December 2021

OCA at 07:16, 5 May 2021

OCA: Protected "7ek5" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ek5 is ON HOLD Authors: Wang, Y., Zang, J. Description: prawn ferritin to coordinate with heavy metal ions Category: Unreleased Structures [[C...