OCA at 16:55, 29 November 2023

OCA — Wed, 29 Nov 2023 16:55:43 GMT

←Older revision		Revision as of 16:55, 29 November 2023
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-	====	+	==Structure of SARS-CoV-2 Beta variant spike receptor-binding domain complexed with human ACE2==
-	<StructureSection load='7ekg' size='340' side='right'caption='[[7ekg]]' scene=''>	+	<StructureSection load='7ekg' size='340' side='right'caption='[[7ekg]], [[Resolution\|resolution]] 2.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ekg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EKG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ekg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ekg OCA], [https://pdbe.org/7ekg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ekg RCSB], [https://www.ebi.ac.uk/pdbsum/7ekg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ekg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.63Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ekg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ekg OCA], [https://pdbe.org/7ekg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ekg RCSB], [https://www.ebi.ac.uk/pdbsum/7ekg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ekg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multiple SARS-CoV-2 variants of concern (VOCs) have been emerging and some have been linked to an increase in case numbers globally. However, there is yet a lack of understanding of the molecular basis for the interactions between the human ACE2 (hACE2) receptor and these VOCs. Here we examined several VOCs including Alpha, Beta, and Gamma, and demonstrate that five variants receptor-binding domain (RBD) increased binding affinity for hACE2, and four variants pseudoviruses increased entry into susceptible cells. Crystal structures of hACE2-RBD complexes help identify the key residues facilitating changes in hACE2 binding affinity. Additionally, soluble hACE2 protein efficiently prevent most of the variants pseudoviruses. Our findings provide important molecular information and may help the development of novel therapeutic and prophylactic agents targeting these emerging mutants.
		+
		+	Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants.,Han P, Su C, Zhang Y, Bai C, Zheng A, Qiao C, Wang Q, Niu S, Chen Q, Zhang Y, Li W, Liao H, Li J, Zhang Z, Cho H, Yang M, Rong X, Hu Y, Huang N, Yan J, Wang Q, Zhao X, Gao GF, Qi J Nat Commun. 2021 Oct 20;12(1):6103. doi: 10.1038/s41467-021-26401-w. PMID:34671049<ref>PMID:34671049</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ekg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Angiotensin-Converting Enzyme 3D structures\|Angiotensin-Converting Enzyme 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Gao GF]]
		+	[[Category: Han PC]]
		+	[[Category: Qi JX]]
		+	[[Category: Su C]]
		+	[[Category: Zhang YF]]

OCA at 14:29, 3 November 2021

OCA — Wed, 03 Nov 2021 14:29:31 GMT

←Older revision		Revision as of 14:29, 3 November 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ekg ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7ekg' size='340' side='right'caption='[[7ekg]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ekg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ekg OCA], [https://pdbe.org/7ekg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ekg RCSB], [https://www.ebi.ac.uk/pdbsum/7ekg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ekg ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:56, 11 August 2021

OCA — Wed, 11 Aug 2021 04:56:13 GMT

←Older revision		Revision as of 04:56, 11 August 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ekg is ON HOLD	+	The entry 7ekg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ekg" [edit=sysop:move=sysop]

OCA — Wed, 14 Apr 2021 05:35:52 GMT

Protected "7ekg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:35, 14 April 2021

OCA: New page: '''Unreleased structure''' The entry 7ekg is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Apr 2021 05:35:51 GMT

New page: '''Unreleased structure''' The entry 7ekg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ekg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7ekg - Revision history

OCA at 16:55, 29 November 2023

OCA at 14:29, 3 November 2021

OCA at 04:56, 11 August 2021

OCA: Protected "7ekg" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ekg is ON HOLD Authors: Description: Category: Unreleased Structures