7el5 - Revision history

OCA at 06:52, 14 September 2022

OCA — Wed, 14 Sep 2022 06:52:08 GMT

←Older revision		Revision as of 06:52, 14 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7el5 is ~~ON HOLD until 2024~~-01-08	+	==Crystal structure of Sizzled protein from Xenopus Laevis==
		+	<StructureSection load='7el5' size='340' side='right'caption='[[7el5]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7el5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EL5 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7el5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7el5 OCA], [https://pdbe.org/7el5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7el5 RCSB], [https://www.ebi.ac.uk/pdbsum/7el5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7el5 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/O73821_XENLA O73821_XENLA]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sizzled (Szl) is both a secreted frizzled related protein (sFRP) and a naturally occurring inhibitor of the zinc metalloproteinase bone morphogenetic protein-1 (BMP-1), a key regulator of extracellular matrix assembly and growth factor activation. Here we present a new crystal structure for Szl which differs from that previously reported by a large scale (90 degrees ) hinge rotation between its cysteine-rich and netrin-like domains. We also present results of a molecular docking analysis showing interactions likely to be involved in the inhibition of BMP-1 activity by Szl. When compared with known structures of BMP-1 in complex with small molecule inhibitors, this reveals features that may be helpful in the design of new inhibitors to prevent the excessive accumulation of extracellular matrix that is the hallmark of fibrotic diseases.

-	~~Authors: Sharma~~, U., ~~Harlos~~, K., Hulmes, D.J.S.~~, Aghajari, N~~.	+	Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1).,Sharma U, Vadon-Le Goff S, Harlos K, Zhao Y, Mariano N, Bijakowski C, Bourhis JM, Moali C, Hulmes DJS, Aghajari N Sci Rep. 2022 Sep 1;12(1):14850. doi: 10.1038/s41598-022-18795-4. PMID:36050373<ref>PMID:36050373</ref>

-	~~Description: Crystal structure~~ of ~~Sizzled protein from Xenopus Laevis~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Aghajari, N]]	+	<div class="pdbe-citations 7el5" style="background-color:#fffaf0;"></div>
-	[[Category: Harlos, K]]	+	== References ==
-	[[Category: Hulmes~~, D.J.S~~]]	+	<references/>
-	[[Category: Sharma, U]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Xenopus laevis]]
		+	[[Category: Aghajari N]]
		+	[[Category: Harlos K]]
		+	[[Category: Hulmes DJS]]
		+	[[Category: Sharma U]]

OCA at 03:52, 13 July 2022

OCA — Wed, 13 Jul 2022 03:52:29 GMT

←Older revision		Revision as of 03:52, 13 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7el5 is ON HOLD until ~~2023~~-07-08	+	The entry 7el5 is ON HOLD until 2024-01-08

	Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N.		Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N.
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	Description: Crystal structure of Sizzled protein from Xenopus Laevis		Description: Crystal structure of Sizzled protein from Xenopus Laevis
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Aghajari, N]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]
-	[[Category: Sharma, U]]
	[[Category: Hulmes, D.J.S]]		[[Category: Hulmes, D.J.S]]
-	[[Category: ~~Aghajari~~, N]]	+	[[Category: Sharma, U]]

OCA at 06:18, 22 June 2022

OCA — Wed, 22 Jun 2022 06:18:47 GMT

←Older revision		Revision as of 06:18, 22 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7el5 is ON HOLD until ~~Jul 08~~ 2023	+	The entry 7el5 is ON HOLD until 2023-07-08

	Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N.		Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N.
Line 7:		Line 7:
	Description: Crystal structure of Sizzled protein from Xenopus Laevis		Description: Crystal structure of Sizzled protein from Xenopus Laevis
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Aghajari, N]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]
-	[[Category: Hulmes, D.J.S]]
	[[Category: Sharma, U]]		[[Category: Sharma, U]]
		+	[[Category: Hulmes, D.J.S]]
		+	[[Category: Aghajari, N]]

OCA at 08:30, 13 April 2022

OCA — Wed, 13 Apr 2022 08:30:18 GMT

←Older revision		Revision as of 08:30, 13 April 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7el5 is ON HOLD until ~~Paper Publication~~	+	The entry 7el5 is ON HOLD until Jul 08 2023

	Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N.		Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N.
Line 7:		Line 7:
	Description: Crystal structure of Sizzled protein from Xenopus Laevis		Description: Crystal structure of Sizzled protein from Xenopus Laevis
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Hulmes, D.J.S]]
	[[Category: Aghajari, N]]		[[Category: Aghajari, N]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]
		+	[[Category: Hulmes, D.J.S]]
	[[Category: Sharma, U]]		[[Category: Sharma, U]]

OCA at 08:02, 12 May 2021

OCA — Wed, 12 May 2021 08:02:29 GMT

←Older revision		Revision as of 08:02, 12 May 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7el5 is ON HOLD	+	The entry 7el5 is ON HOLD until Paper Publication

	Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N.		Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N.

OCA: Protected "7el5" [edit=sysop:move=sysop]

OCA — Wed, 14 Apr 2021 05:36:47 GMT

Protected "7el5" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:36, 14 April 2021

OCA: New page: '''Unreleased structure''' The entry 7el5 is ON HOLD Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N. Description: Crystal structure of Sizzled protein from Xenopus Laevis...

OCA — Wed, 14 Apr 2021 05:36:46 GMT

New page: '''Unreleased structure''' The entry 7el5 is ON HOLD Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N. Description: Crystal structure of Sizzled protein from Xenopus Laevis...

New page

'''Unreleased structure'''

The entry 7el5 is ON HOLD

Authors: Sharma, U., Harlos, K., Hulmes, D.J.S., Aghajari, N.

Description: Crystal structure of Sizzled protein from Xenopus Laevis
[[Category: Unreleased Structures]]
[[Category: Hulmes, D.J.S]]
[[Category: Aghajari, N]]
[[Category: Harlos, K]]
[[Category: Sharma, U]]