7enf - Revision history

OCA at 07:52, 21 September 2022

OCA — Wed, 21 Sep 2022 07:52:08 GMT

←Older revision		Revision as of 07:52, 21 September 2022
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-	====	+	==Cryo-EM structure of the SARS-CoV-2 S-6P in complex with Fab30==
-	<StructureSection load='7enf' size='340' side='right'caption='[[7enf]]' scene=''>	+	<StructureSection load='7enf' size='340' side='right'caption='[[7enf]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7enf]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ENF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ENF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7enf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7enf OCA], [https://pdbe.org/7enf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7enf RCSB], [https://www.ebi.ac.uk/pdbsum/7enf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7enf ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7enf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7enf OCA], [https://pdbe.org/7enf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7enf RCSB], [https://www.ebi.ac.uk/pdbsum/7enf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7enf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Wang XF]]
		+	[[Category: Zhu YQ]]

OCA at 10:22, 6 April 2022

OCA — Wed, 06 Apr 2022 10:22:47 GMT

←Older revision		Revision as of 10:22, 6 April 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7enf ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7enf' size='340' side='right'caption='[[7enf]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7enf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7enf OCA], [https://pdbe.org/7enf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7enf RCSB], [https://www.ebi.ac.uk/pdbsum/7enf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7enf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:01, 25 June 2021

OCA — Fri, 25 Jun 2021 06:01:51 GMT

←Older revision		Revision as of 06:01, 25 June 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7enf is ON HOLD	+	The entry 7enf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7enf" [edit=sysop:move=sysop]

OCA — Wed, 28 Apr 2021 04:11:56 GMT

Protected "7enf" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:11, 28 April 2021

OCA: New page: '''Unreleased structure''' The entry 7enf is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Apr 2021 04:11:55 GMT

New page: '''Unreleased structure''' The entry 7enf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7enf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]