OCA at 16:58, 29 November 2023

OCA — Wed, 29 Nov 2023 16:58:48 GMT

←Older revision		Revision as of 16:58, 29 November 2023
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	==Crystal structure of ZYG11B bound to GGFN degron==		==Crystal structure of ZYG11B bound to GGFN degron==
-	<StructureSection load='7ep2' size='340' side='right'caption='[[7ep2]]' scene=''>	+	<StructureSection load='7ep2' size='340' side='right'caption='[[7ep2]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EP2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ep2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EP2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ep2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ep2 OCA], [https://pdbe.org/7ep2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ep2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ep2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ep2 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.38Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ep2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ep2 OCA], [https://pdbe.org/7ep2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ep2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ep2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ep2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ZY11B_HUMAN ZY11B_HUMAN] Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098).<ref>PMID:31273098</ref> <ref>PMID:33093214</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N-degron pathways are a set of proteolytic systems that target the N-terminal destabilizing residues of substrates for proteasomal degradation. Recently, the Gly/N-degron pathway has been identified as a new branch of the N-degron pathway. The N-terminal glycine degron (Gly/N-degron) is recognized by ZYG11B and ZER1, the substrate receptors of the Cullin 2-RING E3 ubiquitin ligase (CRL2). Here we present the crystal structures of ZYG11B and ZER1 bound to various Gly/N-degrons. The structures reveal that ZYG11B and ZER1 utilize their armadillo (ARM) repeats forming a deep and narrow cavity to engage mainly the first four residues of Gly/N-degrons. The alpha-amino group of the Gly/N-degron is accommodated in an acidic pocket by five conserved hydrogen bonds. These structures, together with biochemical studies, decipher the molecular basis for the specific recognition of the Gly/N-degron by ZYG11B and ZER1, providing key information for future structure-based chemical probe design.
		+
		+	Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1).,Yan X, Li Y, Wang G, Zhou Z, Song G, Feng Q, Zhao Y, Mi W, Ma Z, Dong C Mol Cell. 2021 Jun 23. pii: S1097-2765(21)00457-3. doi:, 10.1016/j.molcel.2021.06.010. PMID:34214466<ref>PMID:34214466</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ep2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li Y]]		[[Category: Li Y]]
	[[Category: Yan X]]		[[Category: Yan X]]

OCA at 09:52, 14 July 2021

OCA — Wed, 14 Jul 2021 09:52:38 GMT

←Older revision		Revision as of 09:52, 14 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ep2 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of ZYG11B bound to GGFN degron==
-		+	<StructureSection load='7ep2' size='340' side='right'caption='[[7ep2]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EP2 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ep2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ep2 OCA], [https://pdbe.org/7ep2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ep2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ep2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ep2 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Li Y]]
		+	[[Category: Yan X]]

OCA at 08:03, 12 May 2021

OCA — Wed, 12 May 2021 08:03:11 GMT

←Older revision		Revision as of 08:03, 12 May 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ep2 is ON HOLD	+	The entry 7ep2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ep2" [edit=sysop:move=sysop]

OCA — Wed, 05 May 2021 07:18:22 GMT

Protected "7ep2" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:18, 5 May 2021

OCA: New page: '''Unreleased structure''' The entry 7ep2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 May 2021 07:18:21 GMT

New page: '''Unreleased structure''' The entry 7ep2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ep2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7ep2 - Revision history

OCA at 16:58, 29 November 2023

OCA at 09:52, 14 July 2021

OCA at 08:03, 12 May 2021

OCA: Protected "7ep2" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ep2 is ON HOLD Authors: Description: Category: Unreleased Structures