7epf - Revision history

OCA at 16:59, 29 November 2023

OCA — Wed, 29 Nov 2023 16:59:12 GMT

←Older revision		Revision as of 16:59, 29 November 2023
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	<StructureSection load='7epf' size='340' side='right'caption='[[7epf]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='7epf' size='340' side='right'caption='[[7epf]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7epf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EPF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7epf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EPF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=J9U:(8~{R})-4-[2,4-bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide'>J9U</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=J9U:(8~{R})-4-[2,4-bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide'>J9U</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7epf OCA], [https://pdbe.org/7epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7epf RCSB], [https://www.ebi.ac.uk/pdbsum/7epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7epf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7epf OCA], [https://pdbe.org/7epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7epf RCSB], [https://www.ebi.ac.uk/pdbsum/7epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7epf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FLAV_DESVH FLAV_DESVH] Low-potential electron donor to a number of redox enzymes.[https://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7epf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7epf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Metabotropic glutamate receptor 3D structures\|Metabotropic glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Du, J]]	+	[[Category: Du J]]
-	[[Category: Han, S]]	+	[[Category: Han S]]
-	[[Category: Lin, S]]	+	[[Category: Lin S]]
-	[[Category: Wang, D]]	+	[[Category: Wang D]]
-	[[Category: Wu, B]]	+	[[Category: Wu B]]
-	[[Category: Zhao, Q]]	+	[[Category: Zhao Q]]
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Membrane protein~~]]	+

OCA at 10:14, 7 July 2021

OCA — Wed, 07 Jul 2021 10:14:06 GMT

←Older revision		Revision as of 10:14, 7 July 2021
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	==Crystal structure of mGlu2 bound to NAM597==		==Crystal structure of mGlu2 bound to NAM597==
-	<StructureSection load='7epf' size='340' side='right'caption='[[7epf]]' scene=''>	+	<StructureSection load='7epf' size='340' side='right'caption='[[7epf]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EPF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7epf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EPF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7epf OCA], [https://pdbe.org/7epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7epf RCSB], [https://www.ebi.ac.uk/pdbsum/7epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7epf ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=J9U:(8~{R})-4-[2,4-bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide'>J9U</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7epf OCA], [https://pdbe.org/7epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7epf RCSB], [https://www.ebi.ac.uk/pdbsum/7epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7epf ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The metabotropic glutamate receptors (mGlus) are involved in the modulation of synaptic transmission and neuronal excitability in the central nervous system(1). These receptors probably exist as both homo- and heterodimers that have unique pharmacological and functional properties(2-4). Here we report four cryo-electron microscopy structures of the human mGlu subtypes mGlu2 and mGlu7, including inactive mGlu2 and mGlu7 homodimers; mGlu2 homodimer bound to an agonist and a positive allosteric modulator; and inactive mGlu2-mGlu7 heterodimer. We observed a subtype-dependent dimerization mode for these mGlus, as a unique dimer interface that is mediated by helix IV (and that is important for limiting receptor activity) exists only in the inactive mGlu2 structure. The structures provide molecular details of the inter- and intra-subunit conformational changes that are required for receptor activation, which distinguish class C G-protein-coupled receptors from those in classes A and B. Furthermore, our structure and functional studies of the mGlu2-mGlu7 heterodimer suggest that the mGlu7 subunit has a dominant role in controlling dimeric association and G-protein activation in the heterodimer. These insights into mGlu homo- and heterodimers highlight the complex landscape of mGlu dimerization and activation.
		+
		+	Structures of human mGlu2 and mGlu7 homo- and heterodimers.,Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J, Sun F, Wu B, Zhao Q Nature. 2021 Jun;594(7864):589-593. doi: 10.1038/s41586-021-03641-w. Epub 2021, Jun 16. PMID:34135509<ref>PMID:34135509</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7epf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Du J]]	+	[[Category: Du, J]]
-	[[Category: Han S]]	+	[[Category: Han, S]]
-	[[Category: Lin S]]	+	[[Category: Lin, S]]
-	[[Category: Wang D]]	+	[[Category: Wang, D]]
-	[[Category: Wu B]]	+	[[Category: Wu, B]]
-	[[Category: Zhao Q]]	+	[[Category: Zhao, Q]]
		+	[[Category: Gpcr]]
		+	[[Category: Membrane protein]]

OCA at 07:31, 25 June 2021

OCA — Fri, 25 Jun 2021 07:31:39 GMT

←Older revision		Revision as of 07:31, 25 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7epf is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of mGlu2 bound to NAM597==
-		+	<StructureSection load='7epf' size='340' side='right'caption='[[7epf]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EPF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7epf OCA], [https://pdbe.org/7epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7epf RCSB], [https://www.ebi.ac.uk/pdbsum/7epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7epf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Du J]]
		+	[[Category: Han S]]
		+	[[Category: Lin S]]
		+	[[Category: Wang D]]
		+	[[Category: Wu B]]
		+	[[Category: Zhao Q]]

OCA at 08:41, 19 May 2021

OCA — Wed, 19 May 2021 08:41:13 GMT

←Older revision		Revision as of 08:41, 19 May 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7epf is ON HOLD	+	The entry 7epf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7epf" [edit=sysop:move=sysop]

OCA — Wed, 05 May 2021 07:19:02 GMT

Protected "7epf" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:19, 5 May 2021

OCA: New page: '''Unreleased structure''' The entry 7epf is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 May 2021 07:19:01 GMT

New page: '''Unreleased structure''' The entry 7epf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7epf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]