7er6 - Revision history

OCA at 17:00, 29 November 2023

OCA — Wed, 29 Nov 2023 17:00:35 GMT

←Older revision		Revision as of 17:00, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='7er6' size='340' side='right'caption='[[7er6]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='7er6' size='340' side='right'caption='[[7er6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7er6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ER6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ER6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7er6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ER6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ER6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7er6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7er6 OCA], [https://pdbe.org/7er6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7er6 RCSB], [https://www.ebi.ac.uk/pdbsum/7er6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7er6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7er6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7er6 OCA], [https://pdbe.org/7er6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7er6 RCSB], [https://www.ebi.ac.uk/pdbsum/7er6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7er6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN]] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>	+	[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 7er6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7er6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Flavin reductase\|Flavin reductase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Griesinger, C]]	+	[[Category: Griesinger C]]
-	[[Category: Ha~~, J H~~]]	+	[[Category: Ha JH]]
-	[[Category: Kim, M]]	+	[[Category: Kim M]]
-	[[Category: Lee, D]]	+	[[Category: Lee D]]
-	[[Category: Ryu~~, K S]]~~	+	[[Category: Ryu KS]]
-	~~[[Category: Biliverdin reductase b]]~~	+
-	~~[[Category: Blvrb]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Platelet]]~~	+
-	~~[[Category: Thrombocytopenia~~]]	+

OCA at 08:36, 23 February 2022

OCA — Wed, 23 Feb 2022 08:36:53 GMT

←Older revision		Revision as of 08:36, 23 February 2022
Line 1:		Line 1:

	==Crystal structure of human Biliverdin IX-beta reductase B==		==Crystal structure of human Biliverdin IX-beta reductase B==
-	<StructureSection load='7er6' size='340' side='right'caption='[[7er6]]' scene=''>	+	<StructureSection load='7er6' size='340' side='right'caption='[[7er6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ER6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ER6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7er6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ER6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ER6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7er6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7er6 OCA], [https://pdbe.org/7er6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7er6 RCSB], [https://www.ebi.ac.uk/pdbsum/7er6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7er6 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7er6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7er6 OCA], [https://pdbe.org/7er6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7er6 RCSB], [https://www.ebi.ac.uk/pdbsum/7er6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7er6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN]] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Biliverdin IXbeta reductase B (BLVRB) has recently been proposed as a novel therapeutic target for thrombocytopenia through its reactive oxygen species (ROS)-associated mechanism. Thus, we aim at repurposing drugs as new inhibitors of BLVRB. Based on IC50 (<5 muM), we have identified 20 compounds out of 1496 compounds from the Food and Drug Administration (FDA)-approved library and have clearly mapped their binding sites to the active site. Furthermore, we show the detailed BLVRB-binding modes and thermodynamic properties (DeltaH, DeltaS, and KD) with nuclear magnetic resonance (NMR) and isothermal titration calorimetry together with complex structures of eight water-soluble compounds. We anticipate that the results will serve as a novel platform for further in-depth studies on BLVRB effects for related functions such as ROS accumulation and megakaryocyte differentiation, and ultimately treatments of platelet disorders.
		+
		+	Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IXbeta Reductase B as a Novel Thrombocytopenia Therapeutic Target.,Kim M, Ha JH, Choi J, Kim BR, Gapsys V, Lee KO, Jee JG, Chakrabarti KS, de Groot BL, Griesinger C, Ryu KS, Lee D J Med Chem. 2021 Dec 27. doi: 10.1021/acs.jmedchem.1c01664. PMID:34957824<ref>PMID:34957824</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7er6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Griesinger C]]	+	[[Category: Griesinger, C]]
-	[[Category: Ha JH]]	+	[[Category: Ha, J H]]
-	[[Category: Kim M]]	+	[[Category: Kim, M]]
-	[[Category: Lee D]]	+	[[Category: Lee, D]]
-	[[Category: Ryu KS]]	+	[[Category: Ryu, K S]]
		+	[[Category: Biliverdin reductase b]]
		+	[[Category: Blvrb]]
		+	[[Category: Inhibitor]]
		+	[[Category: Nadp]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Platelet]]
		+	[[Category: Thrombocytopenia]]

OCA at 07:27, 19 January 2022

OCA — Wed, 19 Jan 2022 07:27:25 GMT

←Older revision		Revision as of 07:27, 19 January 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7er6 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human Biliverdin IX-beta reductase B==
-		+	<StructureSection load='7er6' size='340' side='right'caption='[[7er6]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ER6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ER6 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7er6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7er6 OCA], [https://pdbe.org/7er6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7er6 RCSB], [https://www.ebi.ac.uk/pdbsum/7er6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7er6 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Griesinger C]]
		+	[[Category: Ha JH]]
		+	[[Category: Kim M]]
		+	[[Category: Lee D]]
		+	[[Category: Ryu KS]]

OCA at 13:22, 2 June 2021

OCA — Wed, 02 Jun 2021 13:22:11 GMT

←Older revision		Revision as of 13:22, 2 June 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7er6 is ON HOLD	+	The entry 7er6 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7er6" [edit=sysop:move=sysop]

OCA — Wed, 12 May 2021 08:05:39 GMT

Protected "7er6" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:05, 12 May 2021

OCA: New page: '''Unreleased structure''' The entry 7er6 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 May 2021 08:05:38 GMT

New page: '''Unreleased structure''' The entry 7er6 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7er6 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]