7erq - Revision history

OCA at 17:01, 29 November 2023

OCA — Wed, 29 Nov 2023 17:01:03 GMT

←Older revision		Revision as of 17:01, 29 November 2023
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	==The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from Cronobacter sakazakii (ligand-free form)==		==The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from Cronobacter sakazakii (ligand-free form)==
-	<StructureSection load='7erq' size='340' side='right'caption='[[7erq]]' scene=''>	+	<StructureSection load='7erq' size='340' side='right'caption='[[7erq]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ERQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ERQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7erq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cronobacter_sakazakii Cronobacter sakazakii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ERQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ERQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7erq OCA], [https://pdbe.org/7erq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7erq RCSB], [https://www.ebi.ac.uk/pdbsum/7erq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7erq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7erq OCA], [https://pdbe.org/7erq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7erq RCSB], [https://www.ebi.ac.uk/pdbsum/7erq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7erq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/H9BVC9_CROSK H9BVC9_CROSK]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SignificanceYeiE has been identified as a master virulence factor of Cronobacter sakazakii. In this study, we determined the crystal structures of the regulatory domain of YeiE in complex with its physiological ligand sulfite ion (SO3(2-)). The structure provides the basis for the molecular mechanisms for sulfite sensing and the ligand-dependent conformational changes of the regulatory domain. The genes under the control of YeiE in response to sulfite were investigated to reveal the functional roles of YeiE in the sulfite tolerance of the bacteria. We propose the molecular mechanism underlying the ability of gram-negative pathogens to defend against the innate immune response involving sulfite, thus providing a strategy to control the pathogenesis of bacteria.
		+
		+	Crystal structures of YeiE from Cronobacter sakazakii and the role of sulfite tolerance in gram-negative bacteria.,Hong S, Kim J, Cho E, Na S, Yoo YJ, Cho YH, Ryu S, Ha NC Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2118002119. doi:, 10.1073/pnas.2118002119. Epub 2022 Mar 10. PMID:35271389<ref>PMID:35271389</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7erq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cronobacter sakazakii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ha N-C]]		[[Category: Ha N-C]]
	[[Category: Hong S]]		[[Category: Hong S]]

OCA at 11:16, 23 March 2022

OCA — Wed, 23 Mar 2022 11:16:17 GMT

←Older revision		Revision as of 11:16, 23 March 2022
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-	'''Unreleased structure'''

-	~~The entry 7erq is ON HOLD until Paper Publication~~	+	==The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from Cronobacter sakazakii (ligand-free form)==
-		+	<StructureSection load='7erq' size='340' side='right'caption='[[7erq]]' scene=''>
-	~~Authors: Hong, S., Ha, N.-C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ERQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ERQ FirstGlance]. <br>
-	~~Description:~~ The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from Cronobacter sakazakii (ligand-free form)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7erq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7erq OCA], [https://pdbe.org/7erq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7erq RCSB], [https://www.ebi.ac.uk/pdbsum/7erq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7erq ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Ha, N.-C]]	+	__TOC__
-	[[Category: Hong, S]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ha N-C]]
		+	[[Category: Hong S]]

OCA at 08:37, 7 July 2021

OCA — Wed, 07 Jul 2021 08:37:56 GMT

←Older revision		Revision as of 08:37, 7 July 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7erq is ON HOLD	+	The entry 7erq is ON HOLD until Paper Publication

	Authors: Hong, S., Ha, N.-C.		Authors: Hong, S., Ha, N.-C.

OCA: Protected "7erq" [edit=sysop:move=sysop]

OCA — Wed, 12 May 2021 08:06:29 GMT

Protected "7erq" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:06, 12 May 2021

OCA: New page: '''Unreleased structure''' The entry 7erq is ON HOLD Authors: Hong, S., Ha, N.-C. Description: The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from...

OCA — Wed, 12 May 2021 08:06:28 GMT

New page: '''Unreleased structure''' The entry 7erq is ON HOLD Authors: Hong, S., Ha, N.-C. Description: The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from...

New page

'''Unreleased structure'''

The entry 7erq is ON HOLD

Authors: Hong, S., Ha, N.-C.

Description: The regulatory domain of YeiE, a sulfite sensing LysR-type transcriptional regulator from Cronobacter sakazakii (ligand-free form)
[[Category: Unreleased Structures]]
[[Category: Ha, N.-C]]
[[Category: Hong, S]]