OCA at 19:34, 29 May 2024

OCA — Wed, 29 May 2024 19:34:01 GMT

←Older revision		Revision as of 19:34, 29 May 2024
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-	====	+	==Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CidA and CidBND1-ND2 from wPip==
-	<StructureSection load='7esy' size='340' side='right'caption='[[7esy]]' scene=''>	+	<StructureSection load='7esy' size='340' side='right'caption='[[7esy]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7esy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Wolbachia_endosymbiont_of_Culex_quinquefasciatus_Pel Wolbachia endosymbiont of Culex quinquefasciatus Pel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ESY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ESY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7esy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7esy OCA], [https://pdbe.org/7esy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7esy RCSB], [https://www.ebi.ac.uk/pdbsum/7esy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7esy ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.297Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7esy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7esy OCA], [https://pdbe.org/7esy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7esy RCSB], [https://www.ebi.ac.uk/pdbsum/7esy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7esy ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Wolbachia bacteria, inherited through the female germ line, infect a large fraction of arthropod species. Many Wolbachia strains manipulate host reproduction, most commonly through cytoplasmic incompatibility (CI). CI, a conditional male sterility, results when Wolbachia-infected male insects mate with uninfected females; viability is restored if the female is similarly infected (called "rescue"). CI is used to help control mosquito-borne viruses such as dengue and Zika, but its mechanisms remain unknown. The coexpressed CI factors CifA and CifB form stable complexes in vitro, but the timing and function of this interaction in the insect are unresolved. CifA expression in the female germ line is sufficient for rescue. We report high-resolution structures of a CI-factor complex, CinA-CinB, which utilizes a unique binding mode between the CinA rescue factor and the CinB nuclease; the structures were validated by biochemical and yeast growth analyses. Importantly, transgenic expression in Drosophila of a nonbinding CinA mutant, designed based on the CinA-CinB structure, suggests CinA expressed in females must bind CinB imported by sperm in order to rescue embryonic viability. Binding between cognate factors is conserved in an enzymatically distinct CI system, CidA-CidB, suggesting universal features in Wolbachia CI induction and rescue.
		+
		+	Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors.,Xiao Y, Chen H, Wang H, Zhang M, Chen X, Berk JM, Zhang L, Wei Y, Li W, Cui W, Wang F, Wang Q, Cui C, Li T, Chen C, Ye S, Zhang L, Ji X, Huang J, Wang W, Wang Z, Hochstrasser M, Yang H Proc Natl Acad Sci U S A. 2021 Oct 12;118(41). pii: 2107699118. doi:, 10.1073/pnas.2107699118. PMID:34620712<ref>PMID:34620712</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7esy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Wolbachia endosymbiont of Culex quinquefasciatus Pel]]
		+	[[Category: Chen X]]
		+	[[Category: Ji XY]]
		+	[[Category: Wang W]]
		+	[[Category: Xiao YJ]]
		+	[[Category: Yang HT]]

OCA at 06:14, 10 November 2021

OCA — Wed, 10 Nov 2021 06:14:33 GMT

←Older revision		Revision as of 06:14, 10 November 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7esy ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7esy' size='340' side='right'caption='[[7esy]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7esy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7esy OCA], [https://pdbe.org/7esy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7esy RCSB], [https://www.ebi.ac.uk/pdbsum/7esy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7esy ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 02:21, 2 July 2021

OCA — Fri, 02 Jul 2021 02:21:50 GMT

←Older revision		Revision as of 02:21, 2 July 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7esy is ON HOLD	+	The entry 7esy is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7esy" [edit=sysop:move=sysop]

OCA — Wed, 19 May 2021 08:46:17 GMT

Protected "7esy" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:46, 19 May 2021

OCA: New page: '''Unreleased structure''' The entry 7esy is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 May 2021 08:46:16 GMT

New page: '''Unreleased structure''' The entry 7esy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7esy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7esy - Revision history

OCA at 19:34, 29 May 2024

OCA at 06:14, 10 November 2021

OCA at 02:21, 2 July 2021

OCA: Protected "7esy" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7esy is ON HOLD Authors: Description: Category: Unreleased Structures