OCA at 17:07, 29 November 2023

OCA — Wed, 29 Nov 2023 17:07:23 GMT

←Older revision		Revision as of 17:07, 29 November 2023
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	==Structure of deamidated Ubiquitin==		==Structure of deamidated Ubiquitin==
-	<StructureSection load='7f0n' size='340' side='right'caption='[[7f0n]]' scene=''>	+	<StructureSection load='7f0n' size='340' side='right'caption='[[7f0n]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7f0n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F0N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f0n OCA], [https://pdbe.org/7f0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f0n RCSB], [https://www.ebi.ac.uk/pdbsum/7f0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f0n ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f0n OCA], [https://pdbe.org/7f0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f0n RCSB], [https://www.ebi.ac.uk/pdbsum/7f0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f0n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RS27A_HUMAN RS27A_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref> Ribosomal protein S27a is a component of the 40S subunit of the ribosome.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chauhan K]]		[[Category: Chauhan K]]
	[[Category: Das R]]		[[Category: Das R]]
	[[Category: Varshney N]]		[[Category: Varshney N]]

OCA at 05:28, 8 June 2022

OCA — Wed, 08 Jun 2022 05:28:07 GMT

←Older revision		Revision as of 05:28, 8 June 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7f0n is ~~ON HOLD until Paper Publication~~	+	==Structure of deamidated Ubiquitin==
-		+	<StructureSection load='7f0n' size='340' side='right'caption='[[7f0n]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F0N FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f0n OCA], [https://pdbe.org/7f0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f0n RCSB], [https://www.ebi.ac.uk/pdbsum/7f0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f0n ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chauhan K]]
		+	[[Category: Das R]]
		+	[[Category: Varshney N]]

OCA at 06:04, 25 June 2021

OCA — Fri, 25 Jun 2021 06:04:18 GMT

←Older revision		Revision as of 06:04, 25 June 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7f0n is ON HOLD	+	The entry 7f0n is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7f0n" [edit=sysop:move=sysop]

OCA — Thu, 17 Jun 2021 13:31:20 GMT

Protected "7f0n" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:31, 17 June 2021

OCA: New page: '''Unreleased structure''' The entry 7f0n is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 17 Jun 2021 13:31:19 GMT

New page: '''Unreleased structure''' The entry 7f0n is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7f0n is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7f0n - Revision history

OCA at 17:07, 29 November 2023

OCA at 05:28, 8 June 2022

OCA at 06:04, 25 June 2021

OCA: Protected "7f0n" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7f0n is ON HOLD Authors: Description: Category: Unreleased Structures