7f2j - Revision history

OCA at 17:08, 29 November 2023

OCA — Wed, 29 Nov 2023 17:08:25 GMT

←Older revision		Revision as of 17:08, 29 November 2023
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	<StructureSection load='7f2j' size='340' side='right'caption='[[7f2j]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='7f2j' size='340' side='right'caption='[[7f2j]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7f2j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F2J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7f2j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F2J FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~, ~~<scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[6j2m\|6j2m]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f2j OCA], [https://pdbe.org/7f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f2j RCSB], [https://www.ebi.ac.uk/pdbsum/7f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f2j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f2j OCA], [https://pdbe.org/7f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f2j RCSB], [https://www.ebi.ac.uk/pdbsum/7f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f2j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FKB53_ARATH FKB53_ARATH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Peptidylprolyl isomerase]]~~	+	[[Category: Saharan K]]
-	[[Category: Saharan, K]]	+	[[Category: Singh AK]]
-	[[Category: Singh~~, A K~~]]	+	[[Category: Vasudevan D]]
-	[[Category: Vasudevan, D]]	+
-	~~[[Category: Dimerization]]~~	+
-	~~[[Category: Fkbp]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Rapamycin~~]]	+

OCA at 11:54, 23 March 2022

OCA — Wed, 23 Mar 2022 11:54:04 GMT

←Older revision		Revision as of 11:54, 23 March 2022
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	==Crystal structure of AtFKBP53 FKBD in complex with rapamycin==		==Crystal structure of AtFKBP53 FKBD in complex with rapamycin==
-	<StructureSection load='7f2j' size='340' side='right'caption='[[7f2j]]' scene=''>	+	<StructureSection load='7f2j' size='340' side='right'caption='[[7f2j]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F2J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7f2j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F2J FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f2j OCA], [https://pdbe.org/7f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f2j RCSB], [https://www.ebi.ac.uk/pdbsum/7f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f2j ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6j2m\|6j2m]]</div></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f2j OCA], [https://pdbe.org/7f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f2j RCSB], [https://www.ebi.ac.uk/pdbsum/7f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f2j ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chemically induced dimerization (CID) is used to induce proximity and result in artificial complex formation between a pair of proteins involved in biological processes in cells to investigate and regulate these processes. The induced heterodimerization of FKBP fusion proteins by rapamycin and FK506 has been extensively exploited as a chemically induced dimerization system to regulate and understand highly dynamic cellular processes. Here, we report the crystal structure of the AtFKBP53 FKBD in complex with rapamycin. The crystal packing reveals an unusual feature whereby two rapamycin molecules appear to mediate homodimerization of the FKBD. The triene arm of rapamycin appears to play a significant role in forming this dimer. This forms the first structural report of rapamycin-mediated homodimerization of an FKBP. The structural information on the rapamycin-mediated FKBD dimerization may be employed to design and synthesize covalently linked dimeric rapamycin, which may subsequently serve as a chemically induced dimerization system for the regulation and characterization of cellular processes.
		+
		+	Crystal packing reveals rapamycin-mediated homodimerization of an FK506-binding domain.,Singh AK, Saharan K, Baral S, Luan S, Vasudevan D Int J Biol Macromol. 2022 Feb 23. pii: S0141-8130(22)00354-3. doi:, 10.1016/j.ijbiomac.2022.02.107. PMID:35218805<ref>PMID:35218805</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7f2j" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Saharan K]]	+	[[Category: Peptidylprolyl isomerase]]
-	[[Category: Singh AK]]	+	[[Category: Saharan, K]]
-	[[Category: Vasudevan D]]	+	[[Category: Singh, A K]]
		+	[[Category: Vasudevan, D]]
		+	[[Category: Dimerization]]
		+	[[Category: Fkbp]]
		+	[[Category: Isomerase]]
		+	[[Category: Rapamycin]]

OCA at 06:05, 9 March 2022

OCA — Wed, 09 Mar 2022 06:05:10 GMT

←Older revision		Revision as of 06:05, 9 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7f2j is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of AtFKBP53 FKBD in complex with rapamycin==
-		+	<StructureSection load='7f2j' size='340' side='right'caption='[[7f2j]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F2J FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f2j OCA], [https://pdbe.org/7f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f2j RCSB], [https://www.ebi.ac.uk/pdbsum/7f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f2j ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Saharan K]]
		+	[[Category: Singh AK]]
		+	[[Category: Vasudevan D]]

OCA at 06:04, 25 June 2021

OCA — Fri, 25 Jun 2021 06:04:55 GMT

←Older revision		Revision as of 06:04, 25 June 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7f2j is ON HOLD	+	The entry 7f2j is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7f2j" [edit=sysop:move=sysop]

OCA — Thu, 17 Jun 2021 13:34:35 GMT

Protected "7f2j" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:34, 17 June 2021

OCA: New page: '''Unreleased structure''' The entry 7f2j is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 17 Jun 2021 13:34:34 GMT

New page: '''Unreleased structure''' The entry 7f2j is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7f2j is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]