OCA at 17:09, 29 November 2023

OCA — Wed, 29 Nov 2023 17:09:04 GMT

←Older revision		Revision as of 17:09, 29 November 2023
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-	====	+	==Crystal structure of Sth1 Bromodomain in complex with H3K14bz peptide==
-	<StructureSection load='7f3s' size='340' side='right'caption='[[7f3s]]' scene=''>	+	<StructureSection load='7f3s' size='340' side='right'caption='[[7f3s]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7f3s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F3S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3s OCA], [https://pdbe.org/7f3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3s RCSB], [https://www.ebi.ac.uk/pdbsum/7f3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3s ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LBZ:(2~{S})-2-azanyl-6-benzamido-hexanoic+acid'>LBZ</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3s OCA], [https://pdbe.org/7f3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3s RCSB], [https://www.ebi.ac.uk/pdbsum/7f3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/H3_YEAST H3_YEAST]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lysine benzoylation (Kbz) is a recently discovered post-translational modification associated with active transcription. However, the proteins for maintaining and interpreting Kbz and the physiological roles of Kbz remain elusive. Here, we systematically characterize writer, eraser, and reader proteins of histone Kbz in S. cerevisiae using proteomic, biochemical, and structural approaches. Our study identifies 27 Kbz sites on yeast histones that can be regulated by cellular metabolic states. The Spt-Ada-Gcn5 acetyltransferase (SAGA) complex and NAD(+)-dependent histone deacetylase Hst2 could function as the writer and eraser of histone Kbz, respectively. Crystal structures of Hst2 complexes reveal the molecular basis for Kbz recognition and catalysis by Hst2. In addition, we demonstrate that a subset of YEATS domains and bromodomains serve as Kbz readers, and structural analyses reveal how YEATS and bromodomains recognize Kbz marks. Moreover, the proteome-wide screening of Kbz-modified proteins identifies 207 Kbz sites on 149 non-histone proteins enriched in ribosome biogenesis, glycolysis/gluconeogenesis, and rRNA processing pathways. Our studies identify regulatory elements for the Kbz pathway and provide a framework for dissecting the biological functions of lysine benzoylation.
		+
		+	Global profiling of regulatory elements in the histone benzoylation pathway.,Wang D, Yan F, Wu P, Ge K, Li M, Li T, Gao Y, Peng C, Chen Y Nat Commun. 2022 Mar 16;13(1):1369. doi: 10.1038/s41467-022-29057-2. PMID:35296687<ref>PMID:35296687</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7f3s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Helicase 3D structures\|Helicase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Saccharomyces cerevisiae S288C]]
		+	[[Category: Chen Y]]
		+	[[Category: Wang D]]
		+	[[Category: Yan F]]

OCA at 06:13, 16 March 2022

OCA — Wed, 16 Mar 2022 06:13:03 GMT

←Older revision		Revision as of 06:13, 16 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7f3s ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7f3s' size='340' side='right'caption='[[7f3s]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3s OCA], [https://pdbe.org/7f3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3s RCSB], [https://www.ebi.ac.uk/pdbsum/7f3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3s ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 08:39, 7 July 2021

OCA — Wed, 07 Jul 2021 08:39:36 GMT

←Older revision		Revision as of 08:39, 7 July 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7f3s is ON HOLD	+	The entry 7f3s is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7f3s" [edit=sysop:move=sysop]

OCA — Fri, 25 Jun 2021 06:07:12 GMT

Protected "7f3s" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:07, 25 June 2021

OCA: New page: '''Unreleased structure''' The entry 7f3s is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 25 Jun 2021 06:07:11 GMT

New page: '''Unreleased structure''' The entry 7f3s is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7f3s is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7f3s - Revision history

OCA at 17:09, 29 November 2023

OCA at 06:13, 16 March 2022

OCA at 08:39, 7 July 2021

OCA: Protected "7f3s" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7f3s is ON HOLD Authors: Description: Category: Unreleased Structures