7f5n - Revision history

OCA at 17:09, 29 November 2023

OCA — Wed, 29 Nov 2023 17:09:52 GMT

←Older revision		Revision as of 17:09, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='7f5n' size='340' side='right'caption='[[7f5n]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='7f5n' size='340' side='right'caption='[[7f5n]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7f5n]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7f5n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F5N FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/Protein~~-~~tyrosine-phosphatase Protein-tyrosine-phosphatase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.~~1.~~3.48 3.1.3.48] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f5n OCA], [https://pdbe.org/7f5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f5n RCSB], [https://www.ebi.ac.uk/pdbsum/7f5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f5n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f5n OCA], [https://pdbe.org/7f5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f5n RCSB], [https://www.ebi.ac.uk/pdbsum/7f5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f5n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PTN2_HUMAN PTN2_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 7f5n" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7f5n" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Hsu S-F]]
-	[[Category: Hsu, S F]]	+	[[Category: Lee C-C]]
-	[[Category: Lee, C C]]	+	[[Category: Lin M-J]]
-	[[Category: Lin, M J]]	+	[[Category: Meng T-C]]
-	[[Category: Meng, T C]]	+	[[Category: Singh JP]]
-	[[Category: Singh~~, J P]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protein tyrosine phosphatase]]~~	+
-	~~[[Category: Ptpn2]]~~	+
-	~~[[Category: Tcptp~~]]	+

OCA at 10:58, 16 February 2022

OCA — Wed, 16 Feb 2022 10:58:47 GMT

←Older revision		Revision as of 10:58, 16 February 2022
Line 1:		Line 1:

	==Crystal structure of TCPTP catalytic domain==		==Crystal structure of TCPTP catalytic domain==
-	<StructureSection load='7f5n' size='340' side='right'caption='[[7f5n]]' scene=''>	+	<StructureSection load='7f5n' size='340' side='right'caption='[[7f5n]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7f5n]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F5N FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f5n OCA], [https://pdbe.org/7f5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f5n RCSB], [https://www.ebi.ac.uk/pdbsum/7f5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f5n ProSAT]</span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f5n OCA], [https://pdbe.org/7f5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f5n RCSB], [https://www.ebi.ac.uk/pdbsum/7f5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f5n ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The T-cell protein tyrosine phosphatase (TCPTP/PTPN2) targets a broad variety of substrates across different subcellular compartments. In spite of that, the structural basis for the regulation of TCPTP's activity remains elusive. Here, we investigated whether the activity of TCPTP is regulated by a potential allosteric site in a comparable manner to its most similar PTP family member (PTP1B/PTPN1). We determined two crystal structures of TCPTP at 1.7 and 1.9 A resolutions that include helix alpha7 at the TCPTP C-terminus. Helix alpha7 has been functionally characterized in PTP1B and was identified as its allosteric switch. However, its function is unknown in TCPTP. Here, we demonstrate that truncation or deletion of helix alpha7 reduced the catalytic efficiency of TCPTP by approximately 4-fold. Collectively, our data supports an allosteric role of helix alpha7 in regulation of TCPTP's activity, similar to its function in PTP1B, and highlights that the coordination of helix alpha7 with the core catalytic domain is essential for the efficient catalytic function of TCPTP.
		+
		+	Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix alpha7 in Phosphatase Activity.,Singh JP, Lin MJ, Hsu SF, Peti W, Lee CC, Meng TC Biochemistry. 2021 Dec 28;60(51):3856-3867. doi: 10.1021/acs.biochem.1c00519., Epub 2021 Dec 15. PMID:34910875<ref>PMID:34910875</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7f5n" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hsu S-F]]	+	[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: Lee C-C]]	+	[[Category: Hsu, S F]]
-	[[Category: Lin M-J]]	+	[[Category: Lee, C C]]
-	[[Category: Meng T-C]]	+	[[Category: Lin, M J]]
-	[[Category: Singh JP]]	+	[[Category: Meng, T C]]
		+	[[Category: Singh, J P]]
		+	[[Category: Hydrolase]]
		+	[[Category: Protein tyrosine phosphatase]]
		+	[[Category: Ptpn2]]
		+	[[Category: Tcptp]]

OCA at 14:08, 29 December 2021

OCA — Wed, 29 Dec 2021 14:08:26 GMT

←Older revision		Revision as of 14:08, 29 December 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7f5n is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of TCPTP catalytic domain==
-		+	<StructureSection load='7f5n' size='340' side='right'caption='[[7f5n]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F5N FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f5n OCA], [https://pdbe.org/7f5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f5n RCSB], [https://www.ebi.ac.uk/pdbsum/7f5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f5n ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hsu S-F]]
		+	[[Category: Lee C-C]]
		+	[[Category: Lin M-J]]
		+	[[Category: Meng T-C]]
		+	[[Category: Singh JP]]

OCA at 08:40, 7 July 2021

OCA — Wed, 07 Jul 2021 08:40:15 GMT

←Older revision		Revision as of 08:40, 7 July 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7f5n is ON HOLD	+	The entry 7f5n is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7f5n" [edit=sysop:move=sysop]

OCA — Fri, 02 Jul 2021 02:24:43 GMT

Protected "7f5n" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:24, 2 July 2021

OCA: New page: '''Unreleased structure''' The entry 7f5n is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 02 Jul 2021 02:24:43 GMT

New page: '''Unreleased structure''' The entry 7f5n is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7f5n is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]