7f6y - Revision history

OCA at 17:10, 29 November 2023

OCA — Wed, 29 Nov 2023 17:10:30 GMT

←Older revision		Revision as of 17:10, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7f6y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F6Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[7f6y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F6Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f6y OCA], [https://pdbe.org/7f6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f6y RCSB], [https://www.ebi.ac.uk/pdbsum/7f6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f6y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f6y OCA], [https://pdbe.org/7f6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f6y RCSB], [https://www.ebi.ac.uk/pdbsum/7f6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f6y ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:31, 3 November 2022

OCA — Thu, 03 Nov 2022 07:31:35 GMT

←Older revision		Revision as of 07:31, 3 November 2022
Line 1:		Line 1:

-	==~~n/a~~==	+	==Complex Structure of antibody BD-503 and RBD-E484K of COVID-19==
-	<StructureSection load='7f6y' size='340' side='right'caption='[[7f6y]]' scene=''>	+	<StructureSection load='7f6y' size='340' side='right'caption='[[7f6y]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F6Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7f6y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F6Y FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f6y OCA], [https://pdbe.org/7f6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f6y RCSB], [https://www.ebi.ac.uk/pdbsum/7f6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f6y ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f6y OCA], [https://pdbe.org/7f6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f6y RCSB], [https://www.ebi.ac.uk/pdbsum/7f6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f6y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~N/a~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Su XD]]
		+	[[Category: Wang B]]
		+	[[Category: Xu H]]
		+	[[Category: Zhao TN]]

OCA at 07:25, 29 June 2022

OCA — Wed, 29 Jun 2022 07:25:42 GMT

←Older revision		Revision as of 07:25, 29 June 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7f6y ~~is ON HOLD until Paper Publication~~	+	==n/a==
-		+	<StructureSection load='7f6y' size='340' side='right'caption='[[7f6y]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F6Y FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f6y OCA], [https://pdbe.org/7f6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f6y RCSB], [https://www.ebi.ac.uk/pdbsum/7f6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f6y ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: N/a]]

OCA at 11:39, 29 December 2021

OCA — Wed, 29 Dec 2021 11:39:45 GMT

←Older revision		Revision as of 11:39, 29 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7f6y is ON HOLD	+	The entry 7f6y is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7f6y" [edit=sysop:move=sysop]

OCA — Wed, 07 Jul 2021 08:40:40 GMT

Protected "7f6y" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:40, 7 July 2021

OCA: New page: '''Unreleased structure''' The entry 7f6y is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 07 Jul 2021 08:40:39 GMT

New page: '''Unreleased structure''' The entry 7f6y is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7f6y is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]