7fb3 - Revision history

OCA at 05:40, 8 September 2022

OCA — Thu, 08 Sep 2022 05:40:12 GMT

←Older revision		Revision as of 05:40, 8 September 2022
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	==SARS-CoV-2 spike protein in one-RBD weak state after CTSL-treatment==		==SARS-CoV-2 spike protein in one-RBD weak state after CTSL-treatment==
-	<StructureSection load='7fb3' size='340' side='right'caption='[[7fb3]]' scene=''>	+	<StructureSection load='7fb3' size='340' side='right'caption='[[7fb3]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FB3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7fb3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FB3 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fb3 OCA], [https://pdbe.org/7fb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fb3 RCSB], [https://www.ebi.ac.uk/pdbsum/7fb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fb3 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fb3 OCA], [https://pdbe.org/7fb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fb3 RCSB], [https://www.ebi.ac.uk/pdbsum/7fb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fb3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
	[[Category: Sun F]]		[[Category: Sun F]]
	[[Category: Tai LH]]		[[Category: Tai LH]]
	[[Category: Zhu Y]]		[[Category: Zhu Y]]

OCA at 05:13, 13 July 2022

OCA — Wed, 13 Jul 2022 05:13:21 GMT

←Older revision		Revision as of 05:13, 13 July 2022
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-	'''Unreleased structure'''

-	~~The entry 7fb3 is ON HOLD until Paper Publication~~	+	==SARS-CoV-2 spike protein in one-RBD weak state after CTSL-treatment==
-		+	<StructureSection load='7fb3' size='340' side='right'caption='[[7fb3]]' scene=''>
-	~~Authors: Zhu, Y., Tai, L.H., Sun, F.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FB3 FirstGlance]. <br>
-	~~Description:~~ SARS-CoV-2 spike protein in one-RBD weak state after CTSL-treatment	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fb3 OCA], [https://pdbe.org/7fb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fb3 RCSB], [https://www.ebi.ac.uk/pdbsum/7fb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fb3 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Tai~~, L.H]]	+	__TOC__
-	[[Category: ~~Zhu, Y~~]]	+	</StructureSection>
-	[[Category: Sun, F]]	+	[[Category: Large Structures]]
		+	[[Category: Sun F]]
		+	[[Category: Tai LH]]
		+	[[Category: Zhu Y]]

OCA at 07:22, 8 September 2021

OCA — Wed, 08 Sep 2021 07:22:20 GMT

←Older revision		Revision as of 07:22, 8 September 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7fb3 is ON HOLD	+	The entry 7fb3 is ON HOLD until Paper Publication

	Authors: Zhu, Y., Tai, L.H., Sun, F.		Authors: Zhu, Y., Tai, L.H., Sun, F.

OCA: Protected "7fb3" [edit=sysop:move=sysop]

OCA — Wed, 14 Jul 2021 08:43:57 GMT

Protected "7fb3" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:43, 14 July 2021

OCA: New page: '''Unreleased structure''' The entry 7fb3 is ON HOLD Authors: Zhu, Y., Tai, L.H., Sun, F. Description: SARS-CoV-2 spike protein in one-RBD weak state after CTSL-treatment [[Category: U...

OCA — Wed, 14 Jul 2021 08:43:56 GMT

New page: '''Unreleased structure''' The entry 7fb3 is ON HOLD Authors: Zhu, Y., Tai, L.H., Sun, F. Description: SARS-CoV-2 spike protein in one-RBD weak state after CTSL-treatment [[Category: U...

New page

'''Unreleased structure'''

The entry 7fb3 is ON HOLD

Authors: Zhu, Y., Tai, L.H., Sun, F.

Description: SARS-CoV-2 spike protein in one-RBD weak state after CTSL-treatment
[[Category: Unreleased Structures]]
[[Category: Tai, L.H]]
[[Category: Zhu, Y]]
[[Category: Sun, F]]