7fcc - Revision history

OCA at 17:14, 29 November 2023

OCA — Wed, 29 Nov 2023 17:14:00 GMT

←Older revision		Revision as of 17:14, 29 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7fcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[7fcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fcc OCA], [https://pdbe.org/7fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fcc RCSB], [https://www.ebi.ac.uk/pdbsum/7fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fcc ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.144Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fcc OCA], [https://pdbe.org/7fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fcc RCSB], [https://www.ebi.ac.uk/pdbsum/7fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fcc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IL1AP_HUMAN IL1AP_HUMAN]] Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.<ref>PMID:9371760</ref> <ref>PMID:10799889</ref> <ref>PMID:12530978</ref>	+	[https://www.uniprot.org/uniprot/IL1AP_HUMAN IL1AP_HUMAN] Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.<ref>PMID:9371760</ref> <ref>PMID:10799889</ref> <ref>PMID:12530978</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:52, 8 September 2022

OCA — Thu, 08 Sep 2022 04:52:07 GMT

←Older revision		Revision as of 04:52, 8 September 2022
Line 3:		Line 3:
	<StructureSection load='7fcc' size='340' side='right'caption='[[7fcc]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='7fcc' size='340' side='right'caption='[[7fcc]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7fcc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7fcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCC FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.6 3.2.2.6] </span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fcc OCA], [https://pdbe.org/7fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fcc RCSB], [https://www.ebi.ac.uk/pdbsum/7fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fcc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fcc OCA], [https://pdbe.org/7fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fcc RCSB], [https://www.ebi.ac.uk/pdbsum/7fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fcc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IL1AP_HUMAN IL1AP_HUMAN]] Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.<ref>PMID:9371760</ref> <ref>PMID:10799889</ref> <ref>PMID:12530978</ref>	+	[[https://www.uniprot.org/uniprot/IL1AP_HUMAN IL1AP_HUMAN]] Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.<ref>PMID:9371760</ref> <ref>PMID:10799889</ref> <ref>PMID:12530978</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wang, X]]	+	[[Category: Wang X]]
-	[[Category: Zhou, J]]	+	[[Category: Zhou J]]
-	~~[[Category: Il-1racpb]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Receptor protein]]~~	+
-	~~[[Category: Tir domain~~]]	+

OCA at 05:06, 10 August 2022

OCA — Wed, 10 Aug 2022 05:06:31 GMT

←Older revision		Revision as of 05:06, 10 August 2022
Line 1:		Line 1:

	==IL-1RAcPb TIR domain==		==IL-1RAcPb TIR domain==
-	<StructureSection load='7fcc' size='340' side='right'caption='[[7fcc]]' scene=''>	+	<StructureSection load='7fcc' size='340' side='right'caption='[[7fcc]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7fcc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fcc OCA], [https://pdbe.org/7fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fcc RCSB], [https://www.ebi.ac.uk/pdbsum/7fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fcc ProSAT]</span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.6 3.2.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fcc OCA], [https://pdbe.org/7fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fcc RCSB], [https://www.ebi.ac.uk/pdbsum/7fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fcc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/IL1AP_HUMAN IL1AP_HUMAN]] Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.<ref>PMID:9371760</ref> <ref>PMID:10799889</ref> <ref>PMID:12530978</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wang X]]	+	[[Category: Wang, X]]
-	[[Category: Zhou J]]	+	[[Category: Zhou, J]]
		+	[[Category: Il-1racpb]]
		+	[[Category: Immune system]]
		+	[[Category: Receptor protein]]
		+	[[Category: Tir domain]]

OCA at 06:46, 20 July 2022

OCA — Wed, 20 Jul 2022 06:46:03 GMT

←Older revision		Revision as of 06:46, 20 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7fcc ~~is ON HOLD until Paper Publication~~	+	==IL-1RAcPb TIR domain==
-		+	<StructureSection load='7fcc' size='340' side='right'caption='[[7fcc]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCC FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fcc OCA], [https://pdbe.org/7fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fcc RCSB], [https://www.ebi.ac.uk/pdbsum/7fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fcc ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Wang X]]
		+	[[Category: Zhou J]]

OCA at 07:22, 8 September 2021

OCA — Wed, 08 Sep 2021 07:22:38 GMT

←Older revision		Revision as of 07:22, 8 September 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7fcc is ON HOLD	+	The entry 7fcc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7fcc" [edit=sysop:move=sysop]

OCA — Wed, 21 Jul 2021 07:48:38 GMT

Protected "7fcc" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:48, 21 July 2021

OCA: New page: '''Unreleased structure''' The entry 7fcc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 21 Jul 2021 07:48:37 GMT

New page: '''Unreleased structure''' The entry 7fcc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7fcc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]