7fiv - Revision history

OCA at 17:16, 29 November 2023

OCA — Wed, 29 Nov 2023 17:16:41 GMT

←Older revision		Revision as of 17:16, 29 November 2023
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-	====	+	==Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CidA and CidBND1-ND2 from wPip(Tunis)==
-	<StructureSection load='7fiv' size='340' side='right'caption='[[7fiv]]' scene=''>	+	<StructureSection load='7fiv' size='340' side='right'caption='[[7fiv]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7fiv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Wolbachia_endosymbiont_of_Culex_pipiens Wolbachia endosymbiont of Culex pipiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FIV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fiv OCA], [https://pdbe.org/7fiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fiv RCSB], [https://www.ebi.ac.uk/pdbsum/7fiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fiv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.59Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fiv OCA], [https://pdbe.org/7fiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fiv RCSB], [https://www.ebi.ac.uk/pdbsum/7fiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fiv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2K9VS01_9RICK A0A2K9VS01_9RICK]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytoplasmic incompatibility (CI) results when Wolbachia bacteria-infected male insects mate with uninfected females, leading to embryonic lethality. "Rescue" of viability occurs if the female harbors the same Wolbachia strain. CI is caused by linked pairs of Wolbachia genes called CI factors (CifA and CifB). The co-evolution of CifA-CifB pairs may account in part for the incompatibility patterns documented in insects infected with different Wolbachia strains, but the molecular mechanisms remain elusive. Here, we use X-ray crystallography and AlphaFold to analyze the CI factors from Wolbachia strain wMel called CidA(wMel) and CidB(wMel). Substituting CidA(wMel) interface residues with those from CidA(wPip) (from strain wPip) enables the mutant protein to bind CidB(wPip) and rescue CidB(wPip)-induced yeast growth defects, supporting the importance of CifA-CifB interaction in CI rescue. Sequence divergence in CidA(wPip) and CidB(wPip) proteins affects their pairwise interactions, which may help explain the complex incompatibility patterns of mosquitoes infected with different wPip strains.
		+
		+	Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue.,Wang H, Xiao Y, Chen X, Zhang M, Sun G, Wang F, Wang L, Zhang H, Zhang X, Yang X, Li W, Wei Y, Yao D, Zhang B, Li J, Cui W, Wang F, Chen C, Shen W, Su D, Bai F, Huang J, Ye S, Zhang L, Ji X, Wang W, Wang Z, Hochstrasser M, Yang H Nat Commun. 2022 Mar 25;13(1):1608. doi: 10.1038/s41467-022-29273-w. PMID:35338130<ref>PMID:35338130</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7fiv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Wolbachia endosymbiont of Culex pipiens]]
		+	[[Category: Chen X]]
		+	[[Category: Ji XY]]
		+	[[Category: Wang W]]
		+	[[Category: Xiao YJ]]
		+	[[Category: Yang HT]]

OCA at 10:23, 6 April 2022

OCA — Wed, 06 Apr 2022 10:23:02 GMT

←Older revision		Revision as of 10:23, 6 April 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7fiv ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7fiv' size='340' side='right'caption='[[7fiv]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fiv OCA], [https://pdbe.org/7fiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fiv RCSB], [https://www.ebi.ac.uk/pdbsum/7fiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fiv ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 11:44, 29 December 2021

OCA — Wed, 29 Dec 2021 11:44:56 GMT

←Older revision		Revision as of 11:44, 29 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7fiv is ON HOLD	+	The entry 7fiv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 13:50, 22 December 2021

OCA — Wed, 22 Dec 2021 13:50:05 GMT

←Older revision		Revision as of 13:50, 22 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7fiv is ON HOLD ~~until Paper Publication~~	+	The entry 7fiv is ON HOLD

	Authors:		Authors:

OCA at 08:06, 15 September 2021

OCA — Wed, 15 Sep 2021 08:06:05 GMT

←Older revision		Revision as of 08:06, 15 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7fiv is ON HOLD	+	The entry 7fiv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7fiv" [edit=sysop:move=sysop]

OCA — Wed, 11 Aug 2021 04:58:34 GMT

Protected "7fiv" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 11 August 2021

OCA: New page: '''Unreleased structure''' The entry 7fiv is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Aug 2021 04:58:33 GMT

New page: '''Unreleased structure''' The entry 7fiv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7fiv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]